Results 51 to 60 of about 2,545,594 (299)

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

Nature, 2019
Experimental models of the human brain are needed for basic understanding of its development and disease1. Human brain organoids hold unprecedented promise for this purpose; however, they are plagued by high organoid-to-organoid variability2,3.
Silvia Velasco, Amanda J. Kedaigle, Sean K. Simmons, A. Nash, M. Rocha, Giorgia Quadrato, B. Paulsen, Lan Nguyen, Xian Adiconis, A. Regev, J. Levin, P. Arlotta   +11 more
semanticscholar   +1 more source

Brain organoids: building higher-order complexity and neural circuitry models

Trends in Biotechnology
Brain organoids are 3D tissue models of the human brain that are derived from pluripotent stem cells (PSCs). They have enabled studies that were previously stymied by the inaccessibility of human brain tissue or the limitations of mouse models of some ...
Gulimiheranmu Maisumu, Stephanie M. Willerth, Michael W. Nestor, B. Waldau, Stefan Schülke, Francesco V. Nardi, Osama Ahmed, You Zhou, Madel Durens, Bo Liang, Abraam M. Yakoub   +10 more
semanticscholar   +1 more source

Cell diversity and network dynamics in photosensitive human brain organoids

Nature, 2017
In vitro models of the developing brain such as three-dimensional brain organoids offer an unprecedented opportunity to study aspects of human brain development and disease.
Giorgia Quadrato, T. Nguyen, Evan Z. Macosko, J. Sherwood, S. M. Yang, D. Berger, Natalie Maria, J. Scholvin, Melissa Goldman, J. Kinney, E. Boyden, J. Lichtman, Ziv M. Williams, S. Mccarroll, P. Arlotta   +14 more
semanticscholar   +1 more source

Applications of organoid technology to brain tumors

CNS Neuroscience & Therapeutics, 2023
AbstractLacking appropriate model impedes basic and preclinical researches of brain tumors. Organoids technology applying on brain tumors enables great recapitulation of the original tumors. Here, we compared brain tumor organoids (BTOs) with common models including cell lines, tumor spheroids, and patient‐derived xenografts.
Jie Wen, Fangkun Liu, Quan Cheng, Nathaniel Weygant, Xisong Liang, Fan Fan, Chuntao Li, Liyang Zhang, Zhixiong Liu   +8 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Modelling Toxoplasma gondii infection in human cerebral organoids

Emerging Microbes and Infections, 2020
Pluripotent stem cell-derived cerebral organoids have the potential to recapitulate the pathophysiology of in vivo human brain tissue, constituting a valuable resource for modelling brain disorders, including infectious diseases.
Hyang-Hee Seo, Hyo-Won Han, Sang-Eun Lee, Sung-Hee Hong, Shin-Hyeong Cho, Sang Cheol Kim, Soo Kyung Koo, Jung-Hyun Kim   +7 more
doaj   +1 more source

Brain organoid-on-chip system to study the effects of breast cancer derived exosomes on the neurodevelopment of brain

Cell Regeneration, 2022
Early human brain development can be affected by multiple prenatal factors that involve chemical exposures in utero, maternal health characteristics such as psychiatric disorders, and cancer.
Kangli Cui, Wenwen Chen, Rongkai Cao, Yingying Xie, Peng Wang, Yunsong Wu, Yaqing Wang, Jianhua Qin   +7 more
doaj   +1 more source

The legal personhood of human brain organoids

Journal of Law and the Biosciences, 2023
Abstract Research using three-dimensional neural tissues derived from human pluripotent stem cells—known as ‘human brain organoids’—has progressed rapidly in recent years. Although related ethical issues have been intensively discussed, legal issues have only been sparsely examined compared with the related ethical issues. In this paper,
Masanori Kataoka, Tsung-Ling Lee, Tsutomu Sawai   +2 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source