Brain organoid protocols and limitations [PDF]
Frontiers in Cellular NeuroscienceStem cell-derived organoid technology is a powerful tool that revolutionizes the field of biomedical research and extends the scope of our understanding of human biology and diseases.
Helen H. Zhao +3 more
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Deciphering brain organoid heterogeneity by identifying key quality determinants [PDF]
Communications BiologyBrain organoids derived from human pluripotent stem cells (hPSCs) hold immense potential for modeling neurodevelopmental processes and disorders. However, their experimental variability and undefined organoid selection criteria for analysis hinder ...
Tom Boerstler +19 more
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Japanese attitudes toward cell donation in human brain organoid research: many oppose broad consent [PDF]
Frontiers in GeneticsIntroductionUnder broad consent, donors are not informed about the specific research projects using their cells; this may lead to the use of cells in ways that conflict with donors' moral beliefs.
Masanori Kataoka +4 more
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Brain organoids and “organoid intelligence”: a neuroethical critique
Bioethics UpdateBackground: The article “Brain organoids and ‘organoid intelligence’” delves into the cutting-edge research surrounding the cultivation and utilization of brain organoids.
Alberto Carrara
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Single-cell analysis reveals shared and distinct molecular signatures in brain organoid models of neurodegeneration and neuroinflammation [PDF]
Alzheimer’s Research & TherapyBackground Alzheimer’s disease (AD) and Parkinson’s disease (PD) are complex neurodegenerative disorders with common pathological features, but the molecular mechanisms underlying their early stages remain poorly understood.
Sophie Le Bars +4 more
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Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model [PDF]
Cell RegenerationAstroglia are integral to brain development and the emergence of neurodevelopmental disorders. However, studying the pathophysiology of human astroglia using brain organoid models has been hindered by inefficient astrogliogenesis.
Rui Dang +8 more
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A review of protocols for brain organoids and applications for disease modeling
STAR Protocols, 2023 Summary: Recent breakthroughs in human stem cell technologies have enabled the generation of 3D brain organoid platforms for modeling human neurodevelopment and disease.
Christopher N. Mayhew, Richa Singhania
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Vascularization of Human Brain Organoids [PDF]
Stem Cells, 2021 Abstract Human brain organoids are three-dimensional tissues that are generated in vitro from pluripotent stem cells and recapitulate the early development of the human brain. Brain organoids consist mainly of neural lineage cells, such as neural stem/precursor cells, neurons, astrocytes, and oligodendrocytes.
Takeshi K. Matsui +3 more
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How well do brain organoids capture your brain?
iScience, 2021 Summary: Brain organoids closely recapitulate many features and characteristics of in vivo brain tissue. This technology in turn allows unprecedented possibilities to investigate brain development and function in the dish.
Jonghun Kim +2 more
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Human Brain Organoids and Consciousness [PDF]
Neuroethics, 2022 AbstractThis article proposes a methodological schema for engaging in a productive discussion of ethical issues regarding human brain organoids (HBOs), which are three-dimensional cortical neural tissues created using human pluripotent stem cells. Although moral consideration of HBOs significantly involves the possibility that they have consciousness ...
Takuya Niikawa +3 more
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