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Brain organoid protocols and limitations [PDF]
Frontiers in Cellular NeuroscienceStem cell-derived organoid technology is a powerful tool that revolutionizes the field of biomedical research and extends the scope of our understanding of human biology and diseases.
Helen H. Zhao +3 more
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Deciphering brain organoid heterogeneity by identifying key quality determinants [PDF]
Communications BiologyBrain organoids derived from human pluripotent stem cells (hPSCs) hold immense potential for modeling neurodevelopmental processes and disorders. However, their experimental variability and undefined organoid selection criteria for analysis hinder ...
Tom Boerstler +19 more
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Japanese attitudes toward cell donation in human brain organoid research: many oppose broad consent [PDF]
Frontiers in GeneticsIntroductionUnder broad consent, donors are not informed about the specific research projects using their cells; this may lead to the use of cells in ways that conflict with donors' moral beliefs.
Masanori Kataoka +4 more
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Brain organoids and “organoid intelligence”: a neuroethical critique
Bioethics UpdateBackground: The article “Brain organoids and ‘organoid intelligence’” delves into the cutting-edge research surrounding the cultivation and utilization of brain organoids.
Alberto Carrara
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European Journal of Cell BiologyThis study aims to provide a comprehensive review of the ethical, legal and social issues in human brain organoid research, with a view to different types of research and applications: in vitro research, transplantation into non-human animals, and ...
Masanori Kataoka +6 more
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Cell ReportsSummary: Human brain organoids are powerful in vitro models for brain development and disease. However, protocol and pluripotent cell line choices influence organoid variability and cell-type representation, complicating their use in biomedical research.
Julia Naas +10 more
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Brain organoid technology in melanoma metastasis to the brain. [PDF]
Melanoma ManagRabinowitz G +3 more
europepmc +4 more sources
Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model [PDF]
Cell RegenerationAstroglia are integral to brain development and the emergence of neurodevelopmental disorders. However, studying the pathophysiology of human astroglia using brain organoid models has been hindered by inefficient astrogliogenesis.
Rui Dang +8 more
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Vascularization of Human Brain Organoids [PDF]
Stem Cells, 2021 Abstract Human brain organoids are three-dimensional tissues that are generated in vitro from pluripotent stem cells and recapitulate the early development of the human brain. Brain organoids consist mainly of neural lineage cells, such as neural stem/precursor cells, neurons, astrocytes, and oligodendrocytes.
Takeshi K. Matsui +3 more
openaire +2 more sources
A review of protocols for brain organoids and applications for disease modeling
STAR Protocols, 2023 Summary: Recent breakthroughs in human stem cell technologies have enabled the generation of 3D brain organoid platforms for modeling human neurodevelopment and disease.
Christopher N. Mayhew, Richa Singhania
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