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Brain organoid protocols and limitations [PDF]
Frontiers in Cellular NeuroscienceStem cell-derived organoid technology is a powerful tool that revolutionizes the field of biomedical research and extends the scope of our understanding of human biology and diseases.
Helen H. Zhao +3 more
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Deciphering brain organoid heterogeneity by identifying key quality determinants [PDF]
Communications BiologyBrain organoids derived from human pluripotent stem cells (hPSCs) hold immense potential for modeling neurodevelopmental processes and disorders. However, their experimental variability and undefined organoid selection criteria for analysis hinder ...
Tom Boerstler +19 more
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Japanese attitudes toward cell donation in human brain organoid research: many oppose broad consent [PDF]
Frontiers in GeneticsIntroductionUnder broad consent, donors are not informed about the specific research projects using their cells; this may lead to the use of cells in ways that conflict with donors' moral beliefs.
Masanori Kataoka +4 more
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European Journal of Cell BiologyThis study aims to provide a comprehensive review of the ethical, legal and social issues in human brain organoid research, with a view to different types of research and applications: in vitro research, transplantation into non-human animals, and ...
Masanori Kataoka +6 more
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Cell ReportsSummary: Human brain organoids are powerful in vitro models for brain development and disease. However, protocol and pluripotent cell line choices influence organoid variability and cell-type representation, complicating their use in biomedical research.
Julia Naas +10 more
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A review of protocols for brain organoids and applications for disease modeling
STAR Protocols, 2023 Summary: Recent breakthroughs in human stem cell technologies have enabled the generation of 3D brain organoid platforms for modeling human neurodevelopment and disease.
Christopher N. Mayhew, Richa Singhania
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How well do brain organoids capture your brain?
iScience, 2021 Summary: Brain organoids closely recapitulate many features and characteristics of in vivo brain tissue. This technology in turn allows unprecedented possibilities to investigate brain development and function in the dish.
Jonghun Kim +2 more
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A beginner’s guide on the use of brain organoids for neuroscientists: a systematic review
Stem Cell Research & Therapy, 2023 Background The first human brain organoid protocol was presented in the beginning of the previous decade, and since then, the field witnessed the development of many new brain region-specific models, and subsequent protocol adaptations and modifications.
Lance A. Mulder +5 more
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Deciphering and reconstitution of positional information in the human brain development
Cell Regeneration, 2021 Organoid has become a novel in vitro model to research human development and relevant disorders in recent years. With many improvements on the culture protocols, current brain organoids could self-organize into a complicated three-dimensional ...
Yi-Fan Wang, Cong Liu, Peng-Fei Xu
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Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements
Frontiers in Neuroscience, 2021 Brain organoids, or cerebral organoids, have become widely used to study the human brain in vitro. As pluripotent stem cell-derived structures capable of self-organization and recapitulation of physiological cell types and architecture, brain organoids ...
Austin P. Passaro +4 more
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