Results 41 to 50 of about 18,873 (192)
The Ethics of Human Brain Organoid Transplantation in Animals. [PDF]
Neuroethics, 2023 ヒト脳組織の動物移植に伴う倫理問題を体系化. 京都大学プレスリリース. 2023-10-19.In this paper, we outline how one might conduct a comprehensive ethical evaluation of human brain organoid transplantation in animals.
Kataoka M +3 more
europepmc +3 more sources
Single-cell brain organoid screening identifies developmental defects in autism [PDF]
, 2022 Supplementary data for the manuscript: Single-cell brain organoid screening identifies developmental defects in ...
Treutlein, Barbara +12 more
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A brain metastasis model for breast cancer using human embryonic stem cell-derived cerebral organoids [PDF]
, 2022 Background Breast cancer is a common cause of brain metastasis. Although breast cancer has relatively high survival rates, its survival rate after metastasis to the brain is lower.
Min Young Lee, Mu Seog Choe
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Bio-Protocol, 2022 Targeting receptor-mediated transcytosis (RMT) is a successful strategy for drug delivery of biologic agents across the blood-brain barrier (BBB).
Elena Kassianidou +3 more
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The Application of Brain Organoids in Assessing Neural Toxicity
Frontiers in Molecular Neuroscience, 2022 The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases ...
Pan Fan +5 more
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Human Organoids for Predictive Toxicology Research and Drug Development
Frontiers in Genetics, 2021 Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or adult tissue stem cells via a process of self-organization that results in the formation of organ-specific cell types.
Toshikatsu Matsui, Tadahiro Shinozawa
doaj +1 more source
Brain Organoids and the Study of Neurodevelopment [PDF]
Trends in Molecular Medicine, 2018 Brain organoids are 3D self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular organization and transcriptional and epigenetic signature of a developing human brain. Advancements using brain organoids have been made to elucidate the genetic basis of certain neurodevelopmental disorders, such as ...
Cleber A. Trujillo, Alysson R. Muotri
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Ethical issues related to brain organoid research [PDF]
, 2020 This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery ...
Scharf-Deering, J. C. +2 more
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Modular 3D printed platform for fluidically connected human brain organoid culture [PDF]
, 2023 Brain organoid technology has transformed both basic and applied biomedical research and paved the way for novel insights into developmental processes and disease states of the human brain. While the use of brain organoids has been rapidly growing in the
Nilsson, Fredrik +7 more
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Activity-induced instabilities of brain organoids [PDF]
The European Physical Journal E, 2021 AbstractWe present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked.
Thijssen, Kristian +2 more
openaire +6 more sources