Results 61 to 70 of about 26,891 (293)

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling [PDF]

, 2019
With 100 billion neurons and 100 trillion synapses, the human brain is not just the most complex organ in the human body, but has also been described as “the most complex thing in the universe.” The limited availability of human living brain tissue for ...
Allende, Almeida, Amenduni, Ananiev, Auger, Avior, Awad, Baarine, Barral, Basuodan, Bershteyn, Bhinge, Biedler, Biedler, Bilican, Bird, Birey, Bousquet, Boza-Moran, Brammer, Brawner, Brewer, Bridget E. Bax, Brodal, Camp, Carlessi, Carpenter, Carter, Chamberlain, Chambers, Chandrasekaran, Chang, Chesselet, Clevers, Cohen, Conti, Corti, Costero, Coyle, Crain, Cugola, Cunningham, Curchoe, Dang, Dario Pacitti, Dawson, DeFelipe, Denham, Denton, Dezonne, Di Lullo, Dickinson, Diez del Corral, Dingle, Djuric, Doerr, Doers, Dotti, Ebert, Edri, Efthymiou, Egawa, Eigentler, Eiraku, Eiraku, Elston, Eyal, Fernandez-Santiago, Fietz, Filis, Foo, Franco, Frotscher, Fuller, Garcez, Gaspard, Ge, Gharib, Giandomenico, Giulian, Goldman, Goldstein, Golgi, Gomes, Gonzalez-Cordero, Gordon, Gotz, Greene, Griesi-Oliveira, Gähwiler, Halevy, Hall, Hansen, Harrison, Harrison, Hartung, Haubensak, Havlicek, Herculano-Houzel, Hick, Higuchi, Higurashi, Hoadley, Hogue, Hogue, Howard, Huang, Hughes, Iefremova, Imura, Itskovitz-Eldor, Jaenisch, Jakel, Janesick, Jang, Jiang, Jiao, Jo, Johns, Kadoshima, Kelava, Kelava, Kim, Kirkeby, Kleinman, Knopfel, Ko, Komssi, Kovalevich, Kuff, Lancaster, Lancaster, Lancaster, Lancaster, Lange, LaVail, Lavazza, Lee, Lee, Lee, Lee, Lee, LePage, Li, Liddelow, Lingor, Liu, Liu, Liu, Liu, Lohle, Lojewski, Ma, Maden, Mansour, Marchetto, Mariani, Mariani, Mastrangelo, Matsui, Mattei, McCarthy, McGivern, McKinney, Mellios, Miranda, Miranda, Miranda, Mishra, Miyata, Mohan, Monzel, Muguruma, Muotri, Nayler, Ng, Nguyen, Nizzardo, Nzou, Okita, Ostergaard, Pacitti, Pacitti, Pahlman, Panicker, Park, Park, Pasca, Pasca, Pasca, Patitucci, Pauklin, Paşca, Pekny, Petros, Pham, Pleasure, Puschmann, Puschmann, Qian, Quadrato, Raja, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Ramón y Cajal, Renner, Reubinoff, Reynolds, Riccardo Privolizzi, Ricciardi, Ring, Robertson, Roth, Rowitch, Sakaguchi, Sanchez-Danes, Sareen, Schuldiner, Schwab, Schwartz, Schwartz, Serio, Shcheglovitov, Shepherd, Shi, Shi, Shipley, Siegenthaler, Sloan, Sneddon, Soldner, Stan, Stubbs, Suga, Sun, Sun, Sun, Sutcliffe, Tachibana, Takahashi, Tang, Temple, Thomson, Tian, Tibbitt, Tiscornia, Tonge, Trilck, Ullrich, Ungrin, Urbach, Uusi-Rauva, Velasco, Vescovi, Vessoni, Vierbuchen, Villanueva, Waddington, Waddington, Walsh, Wang, Watanabe, Wataya, Whetsell, Williams, Wilson, Wood, Workman, Wu, Xu, Yakoub, Yakoub, Yamashita, Yang, Yang, Ye, Yin, Ying, Yoshida, Zhang, Zhang, Zhang, Zhu, Zhu, Zhu   +285 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays

Fluids and Barriers of the CNS, 2021
Background The pathways that control protein transport across the blood–brain barrier (BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB in vitro, current models are not suitable for systematic analysis of the ...
Claire Simonneau, Martina Duschmalé, Alina Gavrilov, Nathalie Brandenberg, Sylke Hoehnel, Camilla Ceroni, Evodie Lassalle, Elena Kassianidou, Hendrik Knoetgen, Jens Niewoehner, Roberto Villaseñor   +10 more
doaj   +1 more source

Brain organoids and insights on human evolution. [PDF]

, 2019
Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions.
Muotri, Alysson R
core  

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. [PDF]

, 2017
Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient ...
A Ootani, A Ralston, A Roostaee, AG Muntean, Aimee Flores, B Ohlstein, B-Z Chen, C Moolenbeek, C Stringari, C Yang, CA Micchelli, CA Micchelli, Carl S. Thummel, CCP Aires, Christian S. Earl, Claire Bensard, D Dutta, D Karolchik, Dean Y. Li, DK Bricker, Don Delker, Dona R. Wisidagama, E Berger, F Cao, H Jiang, H Li, H Li, H Tateno, Heather R. Christofk, Helong Zhao, I Martínez-Reyes, J Benavides, J Wang, J Wang, James E. Cox, Jared Rutter, Jason Tanner, JC Schell, Jeffrey Mohlman, JL Golob, John C. Schell, JS Wu, K Birsoy, K Ito, K Nishino, K Weber, Kristofor A. Olson, KT Pate, KW McCool, LB Sullivan, Lei Jiang, Lise K. Sorensen, LK Boroughs, LR Edmunds, LR Gray, M Uhlen, M Uhlen, MA Keller, Mary P. Bronner, MB Gerstein, MJ Dailey, MJ Rodríguez-Colman, N Barker, N Buchon, NM Vacanti, O Warburg, PA Vigueira, Peng Wei, Priyanka Kanth, R Camarda, Ralph J. DeBerardinis, RB Flavell, Ren Miao, RW Daniels, S Beyaz, S Herzig, S Simmini, T Bender, T Sato, T Sato, T Sato, T Simsek, T. Cameron Waller, William E. Lowry, X Yin, X-M Wang, Y-Y Fan   +86 more
core   +1 more source

Vascularized human brain organoid on-chip

Lab on a Chip, 2023
We review the existingin vitrohuman brain models and elaborate on various strategies that enable the curation of a vascularized human brain organoid using microfluidic devices.
Sin Yen Tan, Xiaohan Feng, Lily Kwan Wai Cheng, Angela Ruohao Wu   +3 more
openaire   +3 more sources

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Human in vitro models for understanding mechanisms of autism spectrum disorder. [PDF]

, 2020
Early brain development is a critical epoch for the development of autism spectrum disorder (ASD). In vivo animal models have, until recently, been the principal tool used to study early brain development and the changes occurring in neurodevelopmental ...
Geschwind, Daniel H, Gordon, Aaron
core  

Investigating pediatric disorders with induced pluripotent stem cells [PDF]

, 2018
The study of disease pathophysiology has long relied on model systems, including animal models and cultured cells. In 2006, Shinya Yamanaka achieved a breakthrough by reprogramming somatic cells into induced pluripotent stem cells (iPSCs).
Cadar, Adrian G., Chun, Young W., Durbin, Matthew D., Hong, Charles C.   +3 more
core   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source