Results 61 to 70 of about 18,873 (192)
Bioengineering an Artificial Human Blood–Brain Barrier in Rodents
Bioengineering, 2019 Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent ...
Kimia Kamal, Ben Waldau
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3D-printed microplate inserts for long term high-resolution imaging of live brain organoids
BMC Biomedical Engineering, 2021 Background Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm of size, which need to be ...
Mariana Oksdath Mansilla +17 more
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Applications of organoid technology to brain tumors
CNS Neuroscience & Therapeutics, 2023 AbstractLacking appropriate model impedes basic and preclinical researches of brain tumors. Organoids technology applying on brain tumors enables great recapitulation of the original tumors. Here, we compared brain tumor organoids (BTOs) with common models including cell lines, tumor spheroids, and patient‐derived xenografts.
Jie Wen +8 more
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Neural Regeneration ResearchHuman brain development is a complex process, and animal models often have significant limitations. To address this, researchers have developed pluripotent stem cell-derived three-dimensional structures, known as brain-like organoids, to more accurately ...
Daiyu Hu +8 more
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Bio-ProtocolAnimal and human stem cell–derived three-dimensional models to study physio-pathological brain functioning are becoming a gold standard for in vitro electrophysiology, as they enable the recapitulation of complex network properties by accounting for ...
Eleonora Pali +16 more
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The legal personhood of human brain organoids
Journal of Law and the Biosciences, 2023 Abstract Research using three-dimensional neural tissues derived from human pluripotent stem cells—known as ‘human brain organoids’—has progressed rapidly in recent years. Although related ethical issues have been intensively discussed, legal issues have only been sparsely examined compared with the related ethical issues. In this paper,
Masanori Kataoka +2 more
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Generation of Human Blood Vessel and Vascularized Cerebral Organoids
Bio-Protocol, 2023 Brain organoids have been widely used to study diseases and the development of the nervous system. Many reports have investigated the application of brain organoids, but most of these models lack vascular structures, which play essential roles in brain ...
Xin Sun +5 more
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The Promise and Potential of Brain Organoids
Advanced Healthcare MaterialsAbstractBrain organoids are 3D in vitro culture systems derived from human pluripotent stem cells that self‐organize to model features of the (developing) human brain. This review examines the techniques behind organoid generation, their current and potential applications, and future directions for the field.
Lena Smirnova, Thomas Hartung
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Recent advances and applications of human brain models
Frontiers in Neural CircuitsRecent advances in human pluripotent stem cell (hPSC) technologies have prompted the emergence of new research fields and applications for human neurons and brain organoids.
Kaneyasu Nishimura +5 more
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The importance of accurate representation of human brain organoid research [PDF]
, 2023 体外で製作されるヒト脳組織について、正確な情報発信の必要性を指摘. 京都大学プレスリリース. 2023-03-30.Representations of brain organoids in the media are often negatively or positively exaggerated without appropriate discussion.
Christopher Gyngell +7 more
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