Results 71 to 80 of about 18,873 (192)

Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids

Communications Biology
Brain organoid models have greatly facilitated our understanding of human brain development and disease. However, key brain cell types, such as microglia, are lacking in most brain organoid models.
Xianwei Chen, Guoqiang Sun, Lizhao Feng, E Tian, Yanhong Shi   +4 more
doaj   +1 more source

Brain Organoids: Emerging Platforms for Modern Neuroscience

Brain Sciences
Brain organoids represent three-dimensional structures that allow for human-specific studies in brain development, pathology and therapeutics. These self-organizing systems, formed through the differentiation of human pluripotent stem cells, can mimic ...
Lian Wang, Liwei Mao, Qing Cao, Xuemei Zong   +3 more
doaj   +1 more source

Microengineered Tools for Studying Brain Organoid Biology [PDF]

, 2020
Human brain organoid, derived from pluripotent stem cells, is the organotypic multicellular construct which emerging as a promising tool for modeling human brain development and related disease.
Yan, Shijun
core  

Reverse engineering human brain evolution using organoid models [PDF]

, 2020
Primate brains vary dramatically in size and organization, but the genetic and developmental basis for these differences has been difficult to study due to lack of experimental models.
Schmitz, Matthew T, Montoya, Sebastian Torres, Mostajo-Radji, Mohammed A, Pollen, Alex A   +3 more
core   +1 more source

Cultures and cures: neurodiversity and brain organoids

BMC Medical Ethics, 2021
Background Research with cerebral organoids is beginning to make significant progress in understanding the etiology of autism spectrum disorder (ASD). Brain organoid models can be grown from the cells of donors with ASD.
Andrew J. Barnhart, Kris Dierickx
doaj   +1 more source

Benchmarking pluripotent stem cell-derived organoid models [PDF]

, 2020
Cerebral organoids are stem cell-derived, self-organizing three-dimensional cultures. Owing to the remarkable degree to which they recreate the cellular diversity observed in the human brain, they have attracted significant interest as a novel model ...
De Los Angeles, Alejandro, Tunbridge, Elizabeth M   +1 more
core   +2 more sources

Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases

Stem Cells International, 2017
In recent years, scientists have made great achievements in understanding the development of human brain and elucidating critical elements of stepwise spatiotemporal control strategies in neural stem cell specification lineage, which facilitates ...
NaiLi Wei, ZiFang Quan, Hailiang Tang, JianHong Zhu   +3 more
doaj   +1 more source

Human brain organoid-on-a-chip to model prenatal nicotine exposure [PDF]

, 2018
Nicotine has been recognized to trigger various neuronal disabilities in the fetal brain and long-lasting behavioral deficits in offspring. However, further understanding of fetal brain development under nicotine exposure is challenging due to the ...
Qin, Jianhua, Wang, Li, Yujuan Zhu, Wang, Yaqing, Li Wang, Yaqing Wang, Jianhua Qin, Zhu, Yujuan   +7 more
core   +1 more source

Vascularizing the brain organoids

Journal of Molecular Cell Biology, 2022
Xin-Yao Sun, Zhen-Ge Luo
openaire   +2 more sources

Exploring the prospects, advancements, and challenges of in vitro modeling of the heart-brain axis

Frontiers in Cellular Neuroscience
Research on bidirectional communication between the heart and brain has often relied on studies involving nonhuman animals. Dependance on animal models offer limited applicability to humans and a lack of high-throughput screening.
Senegal Alfred Mabry, Narciso Pavon
doaj   +1 more source