Results 81 to 90 of about 18,873 (192)
Cell Stem Cell, 2018 In large mammalian brains, including those of humans, the surface of the cortex is highly folded. How these convolutions form is still unclear, but recent work in Nature Physics by Karzbrun et al. (2018) supports a mechanism involving differential surface swelling combined with internal constraint.
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Nature CommunicationsTo comprehend the volumetric neural connectivity of a brain organoid, it is crucial to monitor the spatiotemporal electrophysiological signals within the organoid, known as intra-organoid signals.
Enji Kim +12 more
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Brain Organoids, the Path Forward?
Voices in BioethicsPhoto by Maxim Berg on Unsplash INTRODUCTION The brain is one of the most foundational parts of being human, and we are still learning about what makes humans unique. Advancements in technology have allowed for the creation of miniature brain structures using pluripotent stem cells to mimic the embryonic human brain.
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Brain Organoid Computing -- an Overview
CoRRThe aim of this paper is to give an overview of brain organoid computing, its characteristics, challenges, as well as possible advantages for future applications in the field of artificial intelligence. An important part is the extensive bibliography covering all relevant aspects and questions on this topic. Brain organoids - three-dimensional in vitro
Yannic Talavera, Bernd Ulmann
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Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids
Cell Reports Medicine, 2020 Summary: Although congenital infection by human cytomegalovirus (HCMV) is well recognized as a leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly understood.
Guoqiang Sun +15 more
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Brain organoids and insights on human evolution [PDF]
F1000Research, 2019 Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions. Although the applications for disease modeling in a dish have become routine, the use of these brain organoids as evolutionary tools is only now getting momentum ...
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Guiding brain organoid vascularization via intravital reverse 3D bioprinting [PDF]
reservedBrain damage caused by conditions such as tumors, strokes, and traumatic injuries leads to cognitive dysfunctions, with limited self-repair capacity due to the brain’s unfavorable microenvironment. Human brain organoids (hBOs) derived from human-
SAFFARI, SADAF
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Approaches to vascularizing human brain organoids
PLOS Biology, 2023 A major challenge in brain organoid technologies is the lack of vasculature. In recent years, innovative approaches have been taken to meet this challenge. A 2020 paper published in PLOS Biology exemplifies the approaches used in this booming field.
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Organoid-ICLIP: Class imbalance-aware vision-language learning for organoid mitosis classification [PDF]
Visual analysis of brain organoid imaging is critical for advancing the understanding of in vitro organoid development. However, precise differentiation of mitotic stages remains challenging due to complex cellular morphology and limited imaging data. To
Anabia Sohail (22171822) +2 more
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Organoid-engineered neurovascular units for drug discovery and neurodegeneration research [PDF]
BioImpactsThe highly selective permeability of the human blood-brain barrier presents a major obstacle to neurological disease modeling. Established 2D cell cultures and animal models are unable to accurately reproduce the physiological and molecular features of ...
Ailar Nakhlband
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