Results 91 to 100 of about 18,873 (192)
Exploring landscapes of brain morphogenesis with organoids
Development, 2018 ABSTRACT The field of developmental neuroscience is benefitting from recent technological advances that allow access to organogenesis in vitro via organoid preparations. These methods have been applied to better understanding neural identity, and have opened up a window into the early events that occur during development of the human ...
Denis Jabaudon, Madeline Lancaster
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Frontiers in Cell and Developmental BiologyBrain organoids have become essential in vitro models for investigating human brain development, function, and disease, including both unguided cerebral organoids and guided region-specific neural models.
Ubashini Vijakumaran +5 more
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Brain Organoids—A Bottom-Up Approach for Studying Human Neurodevelopment
Bioengineering, 2019 Brain organoids have recently emerged as a three-dimensional tissue culture platform to study the principles of neurodevelopment and morphogenesis. Importantly, brain organoids can be derived from human stem cells, and thus offer a model system for early
Eyal Karzbrun, Orly Reiner
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Organoids as a Human Brain Model for Alzheimer’s Disease [PDF]
embargoed_20260830Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder marked by the accumulation of amyloid beta (Aβ) plaques, associated immune system dysregulation, and progressive loss of memory and cognitive function.
SAEEYEKTA, FAEZEH
core
Non-invasive label-free imaging analysis pipeline for in situ characterization of 3D brain organoids
Scientific ReportsBrain organoids provide a unique opportunity to model organ development in a system similar to human organogenesis in vivo. Brain organoids thus hold great promise for drug screening and disease modeling.
Caroline E. Serafini +7 more
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The donation of human biological material for brain organoid research: the problems of consciousness and consent [PDF]
Human brain organoids are three-dimensional masses of tissues derived from human stem cells that partially recapitulate the characteristics of the human brain.
Kataoka, Masanori +7 more
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BMC Research NotesBackground One of the most important and devastating side effects of breast cancer is brain metastasis. Our understanding of cancer heterogeneity is revolutionized by tumoral organoids and seems promising for personalized medicine.
Sepehr Zamani +2 more
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BOrg: A Brain Organoid-Based Mitosis Dataset for Automatic Analysis of Brain Diseases [PDF]
Recent advances have enabled the study of human brain development using brain organoids derived from stem cells. Quantifying cellular processes like mitosis in these organoids offers insights into neurodevelopmental disorders, but the manual analysis is ...
Bhattacharya, Bidisha +4 more
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When Is a Brain Organoid a Sentience Candidate? [PDF]
It would be unwise to dismiss the possibility of human brain organoids developing sentience. However, scepticism about this idea is appropriate when considering current organoids.
Birch, Jonathan
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npj Precision OncologyIDH-mutant gliomas show prognostic heterogeneity despite favorable overall outcomes, necessitating refined molecular classification. While the extracellular matrix (ECM) critically regulates tumor progression, immunity, and EMT, its prognostic ...
Yanfei Wei +10 more
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