Results 101 to 110 of about 18,873 (192)

Emerging brain organoids: 3D models to decipher, identify and revolutionize brain

Bioactive Materials
Brain organoids are an emerging in vitro 3D brain model that is integrated from pluripotent stem cells. This model mimics the human brain’s developmental process and disease-related phenotypes to a certain extent while advancing the development of human ...
Yuli Zhao, Ting Wang, Jiajun Liu, Ze Wang, Yuan Lu   +4 more
doaj   +1 more source

Brain organoids-on-chip for neural diseases modeling: History, challenges and trends

Journal of Pharmaceutical Analysis
Brain organoid-on-chip platforms have emerged as groundbreaking tools in neural disease modeling and drug discovery, offering a unique and highly accurate simulation of human organ physiology and function compared with traditional cell culture systems ...
Hongyong Zhang, Nan Huang, Sumin Bian, Mohamad Sawan   +3 more
doaj   +1 more source

A home for brain organoids [PDF]

Nature Methods, 2018
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Increased reproducibility of brain organoids through controlled fluid dynamics

EMBO Reports
Brain organoids are a promising model for studying human neurodevelopment and disease. Despite the potential, their 3D structure exhibits high variability during differentiation across batches and cell lines, presenting a significant challenge for ...
Giuseppe Aiello, Mohamed Nemir, Barbora Vidimova, Cindy Ramel, Joanna Viguie, Arianna Ravera, Krzysztof Wrzesinski, Claudia Bagni   +7 more
doaj   +1 more source

Human Brain Organoids: Development and Applications

Journal of Microbiology and Biotechnology
Brain organoids are three-dimensional structures generated from pluripotent stem cells, closely resembling the embryonic human brain. They exhibit gene expression patterns and signaling pathways similar to those in the developing human brain, facilitating the study of the molecular mechanisms underlying brain development, as well as genetic and ...
Hongxi, Wu, Ruting, Wang, Yiyang, Liu, Qinglian, Huang, Jibing, Chen, Feng, Jiang   +5 more
openaire   +2 more sources

Pluripotent stem cells-based neural organoids for modelling human brain development and diseases

Cell & Bioscience
Brain organoids have emerged as transformative in vitro models for studying human neurodevelopment, neural disorders, and evolutionary brain complexity. This review systematically compares neural development in mice and humans, reflecting the limitations
Lingling Tong, Peiqi Tian, Ruoxi Wang, Shiyun Niu, Ruoming Wang, Yaxuan Ye, Yuxin Wu, Wenjing Zhang, Yueqi Wang, Angelica Foggetti, Di Chen   +10 more
doaj   +1 more source

Ethical aspects of brain organoid research in news reports: An exploratory descriptive analysis [PDF]

Ide K, Matsuoka N, Fujita M. Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis. Medicina. 2021; 57(6):532.
Ide, Kazuki, Fujita, Misao, Matsuoka, Norihiro   +2 more
core   +1 more source

Bioengineering of brain organoids

, 2023
Understanding the human brain is an exciting challenge in particular for scientists. Studying the behavior of the human brain can lead to understanding the causes of several diseases and delineate a path to find possible cures. The use of animal models has helped scientist historically to meet these goals; however, there are important differences ...
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Editorial: Brain Organoids: Modeling in Neuroscience [PDF]

Frontiers in Cellular Neuroscience, 2020
Matteo Bordoni, Alysson R. Muotri, Alysson R. Muotri, Cristina Cereda   +3 more
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Why brain organoids are not conscious yet

Patterns
Rapid advances in human brain organoid technologies have prompted the question of their consciousness. Although brain organoids resemble many facets of the brain, their shortcomings strongly suggest that they do not fit any of the operational definitions of consciousness.
openaire   +4 more sources