Results 51 to 60 of about 18,873 (192)
Cell Reports, 2017 Summary: The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain development and disease.
Momoko Watanabe +22 more
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A low-cost 3D printed microfluidic bioreactor and imaging chamber for live-organoid imaging [PDF]
, 2021 Organoids are biological systems grown in vitro and are observed to self-organize into 3D cellular tissues of specific organs. Brain organoids have emerged as valuable models for the study of human brain development in health and disease. Researchers are
Chloe Delepine +11 more
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The welfare of brain organoids
Molecular Psychology: Brain, Behavior, and Society, 2023 One of the most urgent challenges arising in bioethics has been the ethical assessment of the use of brain organoids, largely because of the possibility of sentience and the potential that if they can feel, then they might suffer. But while there is a growing literature on the possibility of sentience in brain organoids and why we should take a ...
Heather Browning, Walter Veit
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Modeling and Targeting Alzheimer’s Disease With Organoids
Frontiers in Pharmacology, 2020 Human neurodegenerative diseases, such as Alzheimer’s disease (AD), are not easily modeled in vitro due to the inaccessibility of brain tissue and the level of complexity required by existing cell culture systems.
Angelos Papaspyropoulos +3 more
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When is a brain organoid a sentience candidate? [PDF]
, 2023 It would be unwise to dismiss the possibility of human brain organoids developing sentience. However, scepticism about this idea is appropriate when considering current organoids.
Birch, Jonathan
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Media portrayal of ethical and social issues in brain organoid research
Philosophy, Ethics, and Humanities in Medicine, 2022 Background Human brain organoids are a valuable research tool for studying brain development, physiology, and pathology. Yet, a host of potential ethical concerns are inherent in their creation.
Abigail Presley +2 more
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Human Brain Organoids as Models for Central Nervous System Viral Infection
Viruses, 2022 Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood, and this is partly due to the limitations of currently used preclinical models. Brain organoid models can overcome some of these limitations, as they are generated
Josse A. Depla +7 more
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A study of Brain Organoid using Holographic Tomography [PDF]
Brain organoids are self-assembled three-dimensional (3D) structures that mimic the embryonic human brain regarding cell types and cytoarchitectures. They successfully replicate numerous essential characteristics of early brain development at molecular ...
Rached, Fathia Ben +3 more
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Recent Advances in Brain Organoid Technology for Human Brain Research [PDF]
, 2022 © 2022 American Chemical Society.Brain organoids are self-assembled three-dimensional aggregates with brain-like cell types and structures and have emerged as new model systems that can be used to investigate human neurodevelopment and neurological ...
Suah Choi, Seung-Woo Cho, Eunseon Jeong
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Microglia innately develop within cerebral organoids
Nature Communications, 2018 Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human ...
Paul R. Ormel +17 more
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