Results 31 to 40 of about 18,873 (192)
Engineered models for studying blood-brain-barrier-associated brain physiology and pathology [PDF]
, 2021 The blood-brain barrier (BBB) is a transport barrier that suppresses the translocation of potentially harmful substances to the brain tissue. Although the BBB is known to be associated with many kinds of neuropathology, such as neuroinflammation and ...
Hong Nam Kim
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Vascularized human brain organoid on-chip [PDF]
, 2023 Modelling the human brain in vitro has been extremely challenging due to the brain's intricate cellular composition and specific structural architecture.
Lily Kwan Wai Cheng +7 more
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Genetic Modification of Brain Organoids [PDF]
Frontiers in Cellular Neuroscience, 2019 Brain organoids have become increasingly used systems allowing 3D-modeling of human brain development, evolution, and disease. To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification techniques.
Fischer, J., Heide, M., Huttner, W.
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Advances and Applications of Brain Organoids
Neuroscience Bulletin, 2023 AbstractUnderstanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.
Yang Li +3 more
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Mapping the Ethical Issues of Brain Organoid Research and Application [PDF]
, 2022 脳オルガノイドの研究と臨床応用での倫理問題を体系化. 京都大学プレスリリース. 2021-04-07.Society is not ready to make human brains. 京都大学プレスリリース. 2021-03-26.In 2008, researchers created human three-dimensional neural tissue – known as the pioneering work of “brain organoids.” In recent years,
Hayashi, Yoshiyuki +8 more
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Brain organoids: Establishment and application
Frontiers in Cell and Developmental Biology, 2022 Brain organoids are produced by the differentiation of pluripotent stem cells under three-dimensional culture conditions by adding neurodevelopment-related regulatory signals. They are similar to the cell composition and anatomical structure of the brain, and can reflect the developmental process of the brain, as well as their physiology, pathology ...
Hao Chen, Xin Jin, Tie Li, Zhuang Ye
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Rapid anticancer drug screening using patient-derived lung cancer organoids: a case report [PDF]
, 2022 A variety of anticancer drugs and targeted agents for lung cancer have been developed, but some patients do not respond to these medications as intended.
Yongki Hwang +6 more
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Gruffi removes stressed cells from brain organoid datasets [POSTER] [PDF]
, 2022 Gruffi removes stressed cells from brain organoid datasets Organoids enable disease modeling in complex and structured human tissue, in vitro. Like most 3D cultures, they lack sufficient oxygen supply, leading to cellular stress.
Julia Naas (12624417) +9 more
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Methodologies for Generating Brain Organoids to Model Viral Pathogenesis in the CNS
Pathogens, 2021 (1) Background: The human brain is of interest in viral research because it is often the target of viruses. Neurological infections can result in consequences in the CNS, which can result in death or lifelong sequelae.
Hannah K. Hopkins +2 more
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Brain organoid formation on decellularized porcine brain ECM hydrogels [PDF]
, 2021 Human brain tissue models such as cerebral organoids are essential tools for developmental and biomedical research. Current methods to generate cerebral organoids often utilize Matrigel as an external scaffold to provide structure and biologically ...
Lachmi Jenndahl +32 more
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