Results 31 to 40 of about 19,404 (259)

Media portrayal of ethical and social issues in brain organoid research

Philosophy, Ethics, and Humanities in Medicine, 2022
Background Human brain organoids are a valuable research tool for studying brain development, physiology, and pathology. Yet, a host of potential ethical concerns are inherent in their creation.
Abigail Presley, Leigh Ann Samsa, Veljko Dubljević   +2 more
doaj   +1 more source

The welfare of brain organoids

Molecular Psychology: Brain, Behavior, and Society, 2023
One of the most urgent challenges arising in bioethics has been the ethical assessment of the use of brain organoids, largely because of the possibility of sentience and the potential that if they can feel, then they might suffer. But while there is a growing literature on the possibility of sentience in brain organoids and why we should take a ...
Heather Browning, Walter Veit
openaire   +1 more source

Transcriptomic Mapping of Neural Diversity, Differentiation and Functional Trajectory in iPSC-Derived 3D Brain Organoid Models

Cells, 2021
Experimental models of the central nervous system (CNS) are imperative for developmental and pathophysiological studies of neurological diseases. Among these models, three-dimensional (3D) induced pluripotent stem cell (iPSC)-derived brain organoid ...
Kiavash Kiaee, Yasamin A. Jodat, Nicole J. Bassous, Navneet Matharu, Su Ryon Shin   +4 more
doaj   +1 more source

Human Brain Organoids as Models for Central Nervous System Viral Infection

Viruses, 2022
Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood, and this is partly due to the limitations of currently used preclinical models. Brain organoid models can overcome some of these limitations, as they are generated
Josse A. Depla, Lance A. Mulder, Renata Vieira de Sá, Morgane Wartel, Adithya Sridhar, Melvin M. Evers, Katja C. Wolthers, Dasja Pajkrt   +7 more
doaj   +1 more source

Microglia innately develop within cerebral organoids

Nature Communications, 2018
Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human ...
Paul R. Ormel, Renata Vieira de Sá, Emma J. van Bodegraven, Henk Karst, Oliver Harschnitz, Marjolein A. M. Sneeboer, Lill Eva Johansen, Roland E. van Dijk, Nicky Scheefhals, Amber Berdenis van Berlekom, Eduardo Ribes Martínez, Sandra Kling, Harold D. MacGillavry, Leonard H. van den Berg, René S. Kahn, Elly M. Hol, Lot D. de Witte, R. Jeroen Pasterkamp   +17 more
doaj   +1 more source

Bioengineering an Artificial Human Blood–Brain Barrier in Rodents

Bioengineering, 2019
Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent ...
Kimia Kamal, Ben Waldau
doaj   +1 more source

3D-printed microplate inserts for long term high-resolution imaging of live brain organoids

BMC Biomedical Engineering, 2021
Background Organoids are a reliable model used in the study of human brain development and under pathological conditions. However, current methods for brain organoid culture generate tissues that range from 0.5 to 2 mm of size, which need to be ...
Mariana Oksdath Mansilla, Camilo Salazar-Hernandez, Sally L. Perrin, Kaitlin G. Scheer, Gökhan Cildir, John Toubia, Kristyna Sedivakova, Melinda N. Tea, Sakthi Lenin, Elise Ponthier, Erica C. F. Yeo, Vinay Tergaonkar, Santosh Poonnoose, Rebecca J. Ormsby, Stuart M. Pitson, Michael P. Brown, Lisa M. Ebert, Guillermo A. Gomez   +17 more
doaj   +1 more source

GSK3ß inhibitor CHIR 99021 modulates cerebral organoid development through dose-dependent regulation of apoptosis, proliferation, differentiation and migration.

PLoS ONE, 2021
Cerebral organoids generated from human pluripotent stem cells (hiPSCs) are unique in their ability to recapitulate human-specific neurodevelopmental events.
Chloe Delepine, Vincent A Pham, Hayley W S Tsang, Mriganka Sur   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Measuring Electrophysiological Activity in Acute Brain Slices, Spheroids, and Organoids Using 3D High-Density Multielectrode Arrays

Bio-Protocol
Animal and human stem cell–derived three-dimensional models to study physio-pathological brain functioning are becoming a gold standard for in vitro electrophysiology, as they enable the recapitulation of complex network properties by accounting for ...
Eleonora Pali, Giorgia Pellavio, Maria Conforti, Arvin Sarkissian, Berna Aliya, Giacomo Sciacca, Supriya Wariyar, Francesco Mainardi, Mariateresa Tedesco, Ivan Verduci, Gendenver Cadiao, Chiara Cervetto, Jimena Andersen, Fikri Birey, Alessandro Maccione, Egidio D’Angelo, Lisa Mapelli   +16 more
doaj   +1 more source