Results 31 to 40 of about 26,891 (293)

Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. [PDF]

, 2020
Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications.
Binette, Francois, Glickman, Randolph D, Nasonkin, Igor O, Petersen-Jones, Simon M, Seiler, Magdalene, Singh, Ratnesh K, Winkler, Paige   +6 more
core   +1 more source

Moral Limits of Brain Organoid Research [PDF]

Journal of Law, Medicine & Ethics, 2019
Brain organoid research raises ethical challenges not seen in other forms of stem cell research. Given that brain organoids partially recapitulate the development of the human brain, it is plausible that brain organoids could one day attain consciousness and perhaps even higher cognitive abilities.
Koplin, JJ, Savulescu, J
openaire   +4 more sources

Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids [PDF]

, 2019
Mutations in the gene encoding the type II transmembrane protease 3 (TMPRSS3) cause human hearing loss, although the underlying mechanisms that result in TMPRSS3-related hearing loss are still unclear.
Alex, Alpha L., Booth, Kevin T., Hashino, Eri, Koehler, Karl R., Lee, Jiyoon, Nelson, Rick F., Nie, Jing, Roth, Adam A., Tang, Pei-Ciao   +8 more
core   +1 more source

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

Cell Reports, 2017
Summary: The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain development and disease.
Momoko Watanabe, Jessie E. Buth, Neda Vishlaghi, Luis de la Torre-Ubieta, Jiannis Taxidis, Baljit S. Khakh, Giovanni Coppola, Caroline A. Pearson, Ken Yamauchi, Danyang Gong, Xinghong Dai, Robert Damoiseaux, Roghiyh Aliyari, Simone Liebscher, Katja Schenke-Layland, Christine Caneda, Eric J. Huang, Ye Zhang, Genhong Cheng, Daniel H. Geschwind, Peyman Golshani, Ren Sun, Bennett G. Novitch   +22 more
doaj   +1 more source

Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]

, 2013
Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa, Compte, Marta, Cuesta, Ángel M., Fernández-Periáñez, Rodrigo, Guijarro-Muñoz, Irene, Molina-Privado, Irene, Rojo, Federico, Sanz, Laura, Sánchez-Martín, David, Zazo, Sandra, Álvarez-Cienfuegos, Ana, Álvarez-Méndez, Ana M., Álvarez-Vallina, Luis   +12 more
core   +4 more sources

Modeling and Targeting Alzheimer’s Disease With Organoids

Frontiers in Pharmacology, 2020
Human neurodegenerative diseases, such as Alzheimer’s disease (AD), are not easily modeled in vitro due to the inaccessibility of brain tissue and the level of complexity required by existing cell culture systems.
Angelos Papaspyropoulos, Magdalini Tsolaki, Nicolas Foroglou, Anastasia A. Pantazaki   +3 more
doaj   +1 more source

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]

, 2020
BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark, Birk, Harjus S, Gupta, Nalin, He, Daniel, Hong, Sung Jun, Horlbeck, Max A, Jain, Miten, Koontz, Mark, Lien, Brian V, Lim, Daniel A, Liu, S John, Malatesta, Martina, Monje, Michelle, Olsen, Hugh E, Pedraza, Leslie, Raleigh, David R, Saha, Parna, Seo, Kyounghee, Thombare, Shivani S, Ullian, Erik M, Weissman, Jonathan S   +20 more
core   +1 more source

Interleukin-17A promotes parietal cell atrophy by inducing apoptosis [PDF]

, 2018
Background & Aims: Atrophic gastritis caused by chronic inflammation in the gastric mucosa leads to the loss of gastric glandular cells, including acid-secreting parietal cells.
Alderuccio, Burclaff, Buzzelli, Caruso, Correa, Correa, Correa, Dai, Degterev, DeLyria, Ding, DiPaolo, DiPaolo, El-Omar, Ferlay, Fox, Ge, Harrington, Hervas-Stubbs, Howlett, Kolls, Landgren, Lennerz, Li, Liao, Machado, McHugh, Merchant, Mills, Moseley, Nam, Nguyen, Nguyen, Nguyen, Nguyen, Onishi, Park, Ramsey, Schumacher, Schwarzenberger, Stummvoll, Varga, Velin, Wada, Yamada, Yamaguchi, Zhang, Zhu   +47 more
core   +3 more sources

Advances and Applications of Brain Organoids

Neuroscience Bulletin, 2023
AbstractUnderstanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.
Yang Li, Peng-Ming Zeng, Jian Wu, Zhen-Ge Luo   +3 more
openaire   +2 more sources

Media portrayal of ethical and social issues in brain organoid research

Philosophy, Ethics, and Humanities in Medicine, 2022
Background Human brain organoids are a valuable research tool for studying brain development, physiology, and pathology. Yet, a host of potential ethical concerns are inherent in their creation.
Abigail Presley, Leigh Ann Samsa, Veljko Dubljević   +2 more
doaj   +1 more source