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Brain organoids and “organoid intelligence”: a neuroethical critique
Bioethics UpdateBackground: The article “Brain organoids and ‘organoid intelligence’” delves into the cutting-edge research surrounding the cultivation and utilization of brain organoids.
Alberto Carrara
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Cultures and cures: neurodiversity and brain organoids [PDF]
BMC Medical Ethics, 2021 Background Research with cerebral organoids is beginning to make significant progress in understanding the etiology of autism spectrum disorder (ASD). Brain organoid models can be grown from the cells of donors with ASD.
Andrew J. Barnhart, Kris Dierickx
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Vascularization of Human Brain Organoids [PDF]
Stem Cells, 2021 Abstract Human brain organoids are three-dimensional tissues that are generated in vitro from pluripotent stem cells and recapitulate the early development of the human brain. Brain organoids consist mainly of neural lineage cells, such as neural stem/precursor cells, neurons, astrocytes, and oligodendrocytes.
Takeshi K. Matsui +3 more
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Human Brain Organoids and Consciousness [PDF]
Neuroethics, 2022 AbstractThis article proposes a methodological schema for engaging in a productive discussion of ethical issues regarding human brain organoids (HBOs), which are three-dimensional cortical neural tissues created using human pluripotent stem cells. Although moral consideration of HBOs significantly involves the possibility that they have consciousness ...
Takuya Niikawa +3 more
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Brain organoid technology in melanoma metastasis to the brain. [PDF]
Melanoma ManagRabinowitz G +3 more
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Mechanics of human brain organoids [PDF]
Physical Review E, 2020 Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex.
Valentina Balbi +2 more
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Applications of brain organoids in neurodevelopment and neurological diseases
Journal of Biomedical Science, 2021 A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. Brain organoid generation methods are abundant
Nan Sun +5 more
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To brain or not to brain organoids
Frontiers in Science, 2023 Brain organoids are a unique template for engineering a new era of bio-inspired supercomputer technology. The power requirements for exploiting brain organoids may be higher than those of the most powerful computers. Further research is needed to accelerate sustainable solutions in brain organoid-leveraged supercomputing technologies.
Magliaro, Chiara, Ahluwalia, Arti
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Advances and Applications of Brain Organoids
Neuroscience Bulletin, 2023 AbstractUnderstanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans.
Yang Li +3 more
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Brain organoids: Establishment and application
Frontiers in Cell and Developmental Biology, 2022 Brain organoids are produced by the differentiation of pluripotent stem cells under three-dimensional culture conditions by adding neurodevelopment-related regulatory signals. They are similar to the cell composition and anatomical structure of the brain, and can reflect the developmental process of the brain, as well as their physiology, pathology ...
Hao Chen, Xin Jin, Tie Li, Zhuang Ye
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