Moral Limits of Brain Organoid Research [PDF]
Journal of Law, Medicine & Ethics, 2019 Brain organoid research raises ethical challenges not seen in other forms of stem cell research. Given that brain organoids partially recapitulate the development of the human brain, it is plausible that brain organoids could one day attain consciousness and perhaps even higher cognitive abilities.
Koplin, JJ, Savulescu, J
core +10 more sources
GSK3ß inhibitor CHIR 99021 modulates cerebral organoid development through dose-dependent regulation of apoptosis, proliferation, differentiation and migration. [PDF]
PLoS ONE, 2021 Cerebral organoids generated from human pluripotent stem cells (hiPSCs) are unique in their ability to recapitulate human-specific neurodevelopmental events.
Chloe Delepine +3 more
doaj +2 more sources
The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects [PDF]
Frontiers in Cellular Neuroscience, 2021 Stroke is a neurological disease responsible for significant morbidity and disability worldwide. However, there remains a dearth of effective therapies.
Guini Song +6 more
doaj +3 more sources
Transcriptomic Mapping of Neural Diversity, Differentiation and Functional Trajectory in iPSC-Derived 3D Brain Organoid Models [PDF]
Cells, 2021 Experimental models of the central nervous system (CNS) are imperative for developmental and pathophysiological studies of neurological diseases. Among these models, three-dimensional (3D) induced pluripotent stem cell (iPSC)-derived brain organoid ...
Kiavash Kiaee +4 more
doaj +2 more sources
Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays [PDF]
Fluids and Barriers of the CNS, 2021 Background The pathways that control protein transport across the blood–brain barrier (BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB in vitro, current models are not suitable for systematic analysis of the ...
Claire Simonneau +10 more
doaj +2 more sources
A large and diverse brain organoid dataset of 1,400 cross-laboratory images of 64 trackable brain organoids [PDF]
Scientific DataBrain organoids represent a useful tool for modeling of neurodevelopmental disorders and can recapitulate brain volume alterations such as microcephaly. To monitor organoid growth, brightfield microscopy images are frequently used and evaluated manually ...
Julian Schröter +6 more
doaj +2 more sources
Toward brain organoid-based precision medicine in neurodegenerative diseases [PDF]
, 2022 In recent years, the concept of precision medicine—an approach to developing personalized drugs for disease prevention or treatment—has emerged as an up-and-coming field in medical research.
Inhee Mook-Jung, Jong-Chan Park
core +1 more source
Glioblastoma organoid technology: an emerging preclinical models for drug discovery [PDF]
, 2022 Glioblastoma multiforme (GBM) is the most prevalent type of primary brain tumor among adults, and it has a median overall survival of 12 to 15 months upon diagnosis.
Shuchang Zhou +3 more
core +1 more source
Recent advances and challenges in organoid-on-a-chip technology [PDF]
, 2022 Conventional 2-dimensional cell culture poorly mimics human-relevant models, which is considered a major challenge in biological research. Organoids are a recent breakthrough in 3-dimensional (3D) in vitro tissue engineering that better reflect the ...
Tae-Hyung Kim, Intan Rosalina Suhito
core +1 more source
How well do brain organoids capture your brain?
iScience, 2021 Summary: Brain organoids closely recapitulate many features and characteristics of in vivo brain tissue. This technology in turn allows unprecedented possibilities to investigate brain development and function in the dish.
Jonghun Kim +2 more
doaj +1 more source