Results 11 to 20 of about 26,891 (293)

A beginner’s guide on the use of brain organoids for neuroscientists: a systematic review

Stem Cell Research & Therapy, 2023
Background The first human brain organoid protocol was presented in the beginning of the previous decade, and since then, the field witnessed the development of many new brain region-specific models, and subsequent protocol adaptations and modifications.
Lance A. Mulder, Josse A. Depla, Adithya Sridhar, Katja Wolthers, Dasja Pajkrt, Renata Vieira de Sá   +5 more
doaj   +1 more source

Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements

Frontiers in Neuroscience, 2021
Brain organoids, or cerebral organoids, have become widely used to study the human brain in vitro. As pluripotent stem cell-derived structures capable of self-organization and recapitulation of physiological cell types and architecture, brain organoids ...
Austin P. Passaro, Austin P. Passaro, Steven L. Stice, Steven L. Stice, Steven L. Stice   +4 more
doaj   +1 more source

Mechanics of human brain organoids [PDF]

Physical Review E, 2020
Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex.
Valentina Balbi, Michel Destrade, Alain Goriely   +2 more
openaire   +3 more sources

Deciphering and reconstitution of positional information in the human brain development

Cell Regeneration, 2021
Organoid has become a novel in vitro model to research human development and relevant disorders in recent years. With many improvements on the culture protocols, current brain organoids could self-organize into a complicated three-dimensional ...
Yi-Fan Wang, Cong Liu, Peng-Fei Xu
doaj   +1 more source

Applications of brain organoids in neurodevelopment and neurological diseases

Journal of Biomedical Science, 2021
A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. Brain organoid generation methods are abundant
Nan Sun, Xiangqi Meng, Yuxiang Liu, Dan Song, Chuanlu Jiang, Jinquan Cai   +5 more
doaj   +1 more source

Morphodynamics of human early brain organoid development. [PDF]

Nature
Jain A, Gut G, Sanchis-Calleja F, Tschannen R, He Z, Luginbühl N, Zenk F, Chrisnandy A, Streib S, Harmel C, Okamoto R, Santel M, Seimiya M, Holtackers R, Rohland JK, Jansen SMJ, Lutolf MP, Camp JG, Treutlein B.   +18 more
europepmc   +2 more sources

Activity-induced instabilities of brain organoids [PDF]

The European Physical Journal E, 2021
AbstractWe present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked.
Thijssen, Kristian, Kusters, Guido LA, Doostmohammadi, Amin   +2 more
openaire   +7 more sources

Methodologies for Generating Brain Organoids to Model Viral Pathogenesis in the CNS

Pathogens, 2021
(1) Background: The human brain is of interest in viral research because it is often the target of viruses. Neurological infections can result in consequences in the CNS, which can result in death or lifelong sequelae.
Hannah K. Hopkins, Elizabeth M. Traverse, Kelli L. Barr   +2 more
doaj   +1 more source

Opportunities for organoids as new models of aging. [PDF]

, 2018
The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use.
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core   +2 more sources

Brain organoids: Establishment and application

Frontiers in Cell and Developmental Biology, 2022
Brain organoids are produced by the differentiation of pluripotent stem cells under three-dimensional culture conditions by adding neurodevelopment-related regulatory signals. They are similar to the cell composition and anatomical structure of the brain, and can reflect the developmental process of the brain, as well as their physiology, pathology ...
Hao Chen, Xin Jin, Tie Li, Zhuang Ye
openaire   +3 more sources