Results 21 to 30 of about 19,404 (259)
Methodologies for Generating Brain Organoids to Model Viral Pathogenesis in the CNS
Pathogens, 2021 (1) Background: The human brain is of interest in viral research because it is often the target of viruses. Neurological infections can result in consequences in the CNS, which can result in death or lifelong sequelae.
Hannah K. Hopkins +2 more
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Genetic Modification of Brain Organoids [PDF]
Frontiers in Cellular Neuroscience, 2019 Brain organoids have become increasingly used systems allowing 3D-modeling of human brain development, evolution, and disease. To be able to make full use of these modeling systems, researchers have developed a growing toolkit of genetic modification techniques.
Fischer, J., Heide, M., Huttner, W.
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Bio-Protocol, 2022 Targeting receptor-mediated transcytosis (RMT) is a successful strategy for drug delivery of biologic agents across the blood-brain barrier (BBB).
Elena Kassianidou +3 more
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The Application of Brain Organoids in Assessing Neural Toxicity
Frontiers in Molecular Neuroscience, 2022 The human brain is a complicated and precisely organized organ. Exogenous chemicals, such as pollutants, drugs, and industrial chemicals, may affect the biological processes of the brain or its function and eventually lead to neurological diseases ...
Pan Fan +5 more
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The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects
Frontiers in Cellular Neuroscience, 2021 Stroke is a neurological disease responsible for significant morbidity and disability worldwide. However, there remains a dearth of effective therapies.
Guini Song +6 more
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Human Organoids for Predictive Toxicology Research and Drug Development
Frontiers in Genetics, 2021 Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or adult tissue stem cells via a process of self-organization that results in the formation of organ-specific cell types.
Toshikatsu Matsui, Tadahiro Shinozawa
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Brain Organoids and the Study of Neurodevelopment [PDF]
Trends in Molecular Medicine, 2018 Brain organoids are 3D self-assembled structures composed of hundreds of thousands to millions of cells that resemble the cellular organization and transcriptional and epigenetic signature of a developing human brain. Advancements using brain organoids have been made to elucidate the genetic basis of certain neurodevelopmental disorders, such as ...
Cleber A. Trujillo, Alysson R. Muotri
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Cell Reports, 2017 Summary: The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain development and disease.
Momoko Watanabe +22 more
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Moral Limits of Brain Organoid Research [PDF]
Journal of Law, Medicine & Ethics, 2019 Brain organoid research raises ethical challenges not seen in other forms of stem cell research. Given that brain organoids partially recapitulate the development of the human brain, it is plausible that brain organoids could one day attain consciousness and perhaps even higher cognitive abilities.
Koplin, JJ, Savulescu, J
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Modeling and Targeting Alzheimer’s Disease With Organoids
Frontiers in Pharmacology, 2020 Human neurodegenerative diseases, such as Alzheimer’s disease (AD), are not easily modeled in vitro due to the inaccessibility of brain tissue and the level of complexity required by existing cell culture systems.
Angelos Papaspyropoulos +3 more
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