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Human Brain Organoids and Consciousness [PDF]
Neuroethics, 2022 AbstractThis article proposes a methodological schema for engaging in a productive discussion of ethical issues regarding human brain organoids (HBOs), which are three-dimensional cortical neural tissues created using human pluripotent stem cells. Although moral consideration of HBOs significantly involves the possibility that they have consciousness ...
Takuya Niikawa +3 more
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Human brain organoids in Alzheimer’s disease [PDF]
, 2021 Alzheimer’s disease (AD) is a progressive neurological disorder that typically involves neuronal damage leading to the deterioration of cognitive and essential body functions in aging brains.
Hansang Cho, You Jung Kang
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A beginner’s guide on the use of brain organoids for neuroscientists: a systematic review
Stem Cell Research & Therapy, 2023 Background The first human brain organoid protocol was presented in the beginning of the previous decade, and since then, the field witnessed the development of many new brain region-specific models, and subsequent protocol adaptations and modifications.
Lance A. Mulder +5 more
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Deciphering and reconstitution of positional information in the human brain development
Cell Regeneration, 2021 Organoid has become a novel in vitro model to research human development and relevant disorders in recent years. With many improvements on the culture protocols, current brain organoids could self-organize into a complicated three-dimensional ...
Yi-Fan Wang, Cong Liu, Peng-Fei Xu
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Electrophysiological Analysis of Brain Organoids: Current Approaches and Advancements
Frontiers in Neuroscience, 2021 Brain organoids, or cerebral organoids, have become widely used to study the human brain in vitro. As pluripotent stem cell-derived structures capable of self-organization and recapitulation of physiological cell types and architecture, brain organoids ...
Austin P. Passaro +4 more
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Mechanics of human brain organoids [PDF]
Physical Review E, 2020 Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs and, in particular, the early morphogenesis of the cortex.
Valentina Balbi +2 more
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Scaffold guided 3D brain organoid models [PDF]
, 2023 The intrinsic self-organisation properties of stem cells provide a unique opportunity to derive 3D in vitro models of organs, known as organoids. In recent years brain organoids have emerged as in vitro model systems that recapitulate certain functional ...
Ritzau-Reid, Kaja
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Applications of brain organoids in neurodevelopment and neurological diseases
Journal of Biomedical Science, 2021 A brain organoid is a self-organizing three-dimensional tissue derived from human embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and functionality of the human brain. Brain organoid generation methods are abundant
Nan Sun +5 more
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To brain or not to brain organoids
Frontiers in Science, 2023 Brain organoids are a unique template for engineering a new era of bio-inspired supercomputer technology. The power requirements for exploiting brain organoids may be higher than those of the most powerful computers. Further research is needed to accelerate sustainable solutions in brain organoid-leveraged supercomputing technologies.
Magliaro, Chiara, Ahluwalia, Arti
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Morphodynamics of human early brain organoid development. [PDF]
NatureBrain organoids enable the mechanistic study of human brain development and provide opportunities to explore self-organization in unconstrained developmental systems1, 2–3.
Jain A +18 more
europepmc +2 more sources