Results 1 to 10 of about 7,831,583 (247)

Bridging pancreatic and hepatic development: overlapping genes and their role in diabetes

Cellular & Molecular Biology Letters
Diabetes mellitus is a complex metabolic disorder characterized by hyperglycemia due to impaired insulin production, action, or both. The Pancreas and Liver play central roles in glucose regulation, and their dysfunction is critical to the onset and ...
Simona S. Ghanem, Tara Al-Barazenji, Rehab Badi, Essam M. Abdelalim   +3 more
doaj   +1 more source

Modelling post-chemotherapy stem cell dynamics in the bone marrow niche of AML patients

Scientific Reports
Acute myeloid leukemia (AML) is a stem cell-driven malignancy of the blood forming (hematopoietic) system. Despite of high dose chemotherapy with toxic side effects, many patients eventually relapse.
Chenxu Zhu, Thomas Stiehl
doaj   +1 more source

Optimal Timing Regularly Outperforms Higher Coverage in Preventative Measles Supplementary Immunization Campaigns

Vaccines
Measles threatens the lives and livelihoods of tens of millions of children and there are countries where routine immunization systems miss enough individuals to create the risk of large outbreaks.
Katherine A. Rosenfeld, Kurt Frey, Kevin A. McCarthy   +2 more
doaj   +1 more source

Perspective on nanochannels as cellular mediators in different disease conditions

Cell Communication and Signaling, 2018
Tunnelling nanotubes (TNTs), also known as membrane nanochannels, are actin-based structures that facilitate cytoplasmic connections for rapid intercellular transfer of signals, organelles and membrane components.
Eshna Jash, Peeyush Prasad, Naveen Kumar, Taruna Sharma, Aaron Goldman, Seema Sehrawat   +5 more
doaj   +1 more source

Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities

Nutrition & Metabolism, 2018
Ageing is a nonmodifiable risk factor that is linked to increased likelihood of cardiovascular morbidities. Whilst many pharmacological interventions currently exist to treat many of these disorders such as statins for hypercholesterolemia or beta ...
Nardev Ramanathan, Esther Tan, Li Jun Loh, Boon Seng Soh, Wei Ney Yap   +4 more
doaj   +1 more source

Generation of an induced pluripotent stem cell line (CSC-32) from a patient with Parkinson's disease carrying a heterozygous variation p.A53T in the SNCA gene

Stem Cell Research, 2020
Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a male patient diagnosed with Parkinson's disease (PD). The patient carries a heterozygous variation p.A53T in the SNCA gene.
Carla Azevedo, Margarita Chumarina, Evgenija Serafimova, Stefano Goldwurm, Anna Collin, Laurent Roybon, Ekaterina Savchenko, Yuriy Pomeshchik   +7 more
doaj   +1 more source

Epidemic progression on networks based on disease generation time

Journal of Biological Dynamics, 2013
We investigate the time evolution of disease spread on a network and present an analytical framework using the concept of disease generation time. Assuming a susceptible–infected–recovered epidemic process, this network-based framework enables us to ...
Bahman Davoudi, Flavia Moser, Fred Brauer, Babak Pourbohloul   +3 more
doaj   +1 more source

Drosophila Models Reveal NAT Complex Roles in Heart Development and Enable Functional Validation of Congenital Heart Disease Variants

Cells
N-terminal acetylation, catalyzed by N-terminal acetyltransferase (NAT) complexes, is one of the most prevalent protein modifications in eukaryotic cells, yet its role in heart development remains poorly understood.
Jun-Yi Zhu, Hannah Seah, Hangnoh Lee, Hanhan Liu, Zhe Han   +4 more
doaj   +1 more source

Spatial model for risk prediction and sub-national prioritization to aid poliovirus eradication in Pakistan

BMC Medicine, 2017
Background Pakistan is one of only three countries where poliovirus circulation remains endemic. For the Pakistan Polio Eradication Program, identifying high risk districts is essential to target interventions and allocate limited resources.
Laina D. Mercer, Rana M. Safdar, Jamal Ahmed, Abdirahman Mahamud, M. Muzaffar Khan, Sue Gerber, Aiden O’Leary, Mike Ryan, Frank Salet, Steve J. Kroiss, Hil Lyons, Alexander Upfill-Brown, Guillaume Chabot-Couture   +12 more
doaj   +1 more source

Dysfunction of Mitochondrial Dynamics Induces Endocytosis Defect and Cell Damage in Drosophila Nephrocytes

Cells
Mitochondria are crucial for cellular ATP production. They are highly dynamic organelles, whose morphology and function are controlled through mitochondrial fusion and fission. The specific roles of mitochondria in podocytes, the highly specialized cells
Jun-yi Zhu, Jianli Duan, Joyce van de Leemput, Zhe Han   +3 more
doaj   +1 more source