Results 1 to 10 of about 1,245,538 (288)
BMC Health Services Research, 2023 Background Primary healthcare systems require adequate staffing to meet the needs of their local population. Guidelines typically use population ratio targets for healthcare workers, such as Ethiopia’s goal of two health extension workers for every five ...
Brittany L. Hagedorn +2 more
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Malaria Journal, 2023 Background As both mechanistic and geospatial malaria modeling methods become more integrated into malaria policy decisions, there is increasing demand for strategies that combine these two methods.
Amelia Bertozzi-Villa +8 more
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Malaria Journal, 2022 Background Gene drives are a genetic engineering method where a suite of genes is inherited at higher than Mendelian rates and has been proposed as a promising new vector control strategy to reinvigorate the fight against malaria in sub-Saharan Africa ...
Shirley Leung +4 more
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Science, 2012 The astonishing recent advances in the technology for determining DNA sequences have made personalized genomics a foreseeable reality for the doctor's office. This technology has started a whole new gold rush for human disease gene discovery and produced an onslaught of information that represents a new challenge in personalized medicine: connecting ...
Aaron D, Gitler, Ruth, Lehmann
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Controlling COVID-19 via test-trace-quarantine
Nature Communications, 2021 Initial COVID-19 containment in the United States focused on limiting mobility, including school and workplace closures, with enormous societal and economic costs. Here, the authors demonstrate the feasibility of a test-trace-quarantine strategy using an
Cliff C. Kerr +16 more
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ZIKV Teratogenesis: Clinical Findings in Humans, Mechanisms and Experimental Models
Frontiers in Virology, 2022 Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) from the Flaviviridae family, first isolated from the Rhesus monkey in 1947 in Uganda. ZIKV is transmitted by mosquito bites, but vertical and sexual transmissions have also been reported.
Fabiele B. Russo +6 more
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Cell & Bioscience, 2021 Background SARS-CoV-2 causes COVID-19 with a widely diverse disease profile that affects many different tissues. The mechanisms underlying its pathogenicity in host organisms remain unclear.
Jun-yi Zhu +4 more
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Malaria Journal, 2019 Background While bed nets and insecticide spraying have had significant impact on malaria burden in many endemic regions, outdoor vector feeding and insecticide resistance may ultimately limit their contribution to elimination and control campaigns ...
Prashanth Selvaraj +4 more
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The risk of type 2 oral polio vaccine use in post-cessation outbreak response
BMC Medicine, 2017 Background Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis.
Kevin A. McCarthy +4 more
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A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
Cell & Bioscience, 2023 Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD
Jin-Gu Lee +6 more
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