Results 11 to 20 of about 565,742 (268)

3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases

open access: yesBiomedicines, 2022
The COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race.
Shirley Pei Shan Chia   +3 more
doaj   +1 more source

Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration

open access: yesJournal of Translational Medicine, 2021
The skin is made up of a plethora of cells arranged in multiple layers with complex and intricate vascular networks, creating a dynamic microenvironment of cells-to-matrix interactions.
Qian Hua Phua   +2 more
doaj   +1 more source

Evaluating COVID-19 reporting data in the context of testing strategies across 31 low- and middle-income countries

open access: yesInternational Journal of Infectious Diseases, 2021
: Background: The case count for coronavirus disease 2019 (COVID-19) is the predominant measure used to track epidemiological dynamics and inform policy decision-making.
Mollie M. Van Gordon   +3 more
doaj   +1 more source

Seasonality and heterogeneity of malaria transmission determine success of interventions in high-endemic settings: a modeling study

open access: yesBMC Infectious Diseases, 2018
Background Malaria transmission is both seasonal and heterogeneous, and mathematical models that seek to predict the effects of possible intervention strategies should accurately capture realistic seasonality of vector abundance, seasonal dynamics of ...
Prashanth Selvaraj   +2 more
doaj   +1 more source

H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development

open access: yesJournal of Cardiovascular Development and Disease, 2023
Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with ...
Jun-yi Zhu   +5 more
doaj   +1 more source

Multiscale modeling in disease

open access: yesCurrent Opinion in Systems Biology, 2021
Multiscale computational modeling aims to connect the complex networks of effects at different length and/or time scales. For example, these networks often include intracellular molecular signaling, crosstalk, and other interactions between neighboring cell populations, and higher levels of emergent phenomena across different regions of tissues and ...
openaire   +2 more sources

Animal Models of Human Disease

open access: yesInternational Journal of Molecular Sciences, 2023
The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled “Animal Models of Human Disease” aimed to collect state-of-the-art primary research studies and review articles from international ...
Lange, Sigrun, Inal, Jameel
openaire   +3 more sources

Sub-national levels and trends in contraceptive prevalence, unmet need, and demand for family planning in Nigeria with survey uncertainty

open access: yesBMC Public Health, 2019
Background Ambitious global goals have been established to provide universal access to affordable modern contraceptive methods. To measure progress toward such goals in populous countries like Nigeria, it’s essential to characterize the current levels ...
Laina D. Mercer   +2 more
doaj   +1 more source

Zebrafish Models of Cerebrovascular Disease [PDF]

open access: yesJournal of Cerebral Blood Flow & Metabolism, 2014
Perturbations in cerebral blood flow and abnormalities in blood vessel structure are the hallmarks of cerebrovascular disease. While there are many genetic and environmental factors that affect these entities through a heterogeneous group of disease processes, the ultimate final pathologic insult in humans is defined as a stroke, or damage to brain ...
Walcott, Brian, Peterson, Randall
openaire   +4 more sources

Effectiveness of reactive case detection for malaria elimination in three archetypical transmission settings: a modelling study

open access: yesMalaria Journal, 2017
Background Reactive case detection could be a powerful tool in malaria elimination, as it selectively targets transmission pockets. However, field operations have yet to demonstrate under which conditions, if any, reactive case detection is best poised ...
Jaline Gerardin   +8 more
doaj   +1 more source

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