Results 11 to 20 of about 1,245,538 (288)

Evaluating COVID-19 reporting data in the context of testing strategies across 31 low- and middle-income countries

International Journal of Infectious Diseases, 2021
: Background: The case count for coronavirus disease 2019 (COVID-19) is the predominant measure used to track epidemiological dynamics and inform policy decision-making.
Mollie M. Van Gordon, Kevin A. McCarthy, Joshua L. Proctor, Brittany L. Hagedorn   +3 more
doaj   +1 more source

Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration

Journal of Translational Medicine, 2021
The skin is made up of a plethora of cells arranged in multiple layers with complex and intricate vascular networks, creating a dynamic microenvironment of cells-to-matrix interactions.
Qian Hua Phua, Hua Alexander Han, Boon-Seng Soh   +2 more
doaj   +1 more source

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
Brentjens, Renier J., Castro Alves, Catarina, Ehrhardt, Harald, Farkasova, Katarina, Groiss, Volker, Horstmann, Martin, Jeremias, Irmela, Ogris, Manfred, Quintanilla-Martinez, Leticia, Schneider, Katja, Terziyska, Nadia, Wagner, Ernst, zur Stadt, Udo   +12 more
core   +3 more sources

Seasonality and heterogeneity of malaria transmission determine success of interventions in high-endemic settings: a modeling study

BMC Infectious Diseases, 2018
Background Malaria transmission is both seasonal and heterogeneous, and mathematical models that seek to predict the effects of possible intervention strategies should accurately capture realistic seasonality of vector abundance, seasonal dynamics of ...
Prashanth Selvaraj, Edward A. Wenger, Jaline Gerardin   +2 more
doaj   +1 more source

3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases

Biomedicines, 2022
The COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race.
Shirley Pei Shan Chia, Sharleen Li Ying Kong, Jeremy Kah Sheng Pang, Boon-Seng Soh   +3 more
doaj   +1 more source

H3K36 Di-Methylation Marks, Mediated by Ash1 in Complex with Caf1-55 and MRG15, Are Required during Drosophila Heart Development

Journal of Cardiovascular Development and Disease, 2023
Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with ...
Jun-yi Zhu, Chen Liu, Xiaohu Huang, Joyce van de Leemput, Hangnoh Lee, Zhe Han   +5 more
doaj   +1 more source

DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways

, 2020
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records.
Anand, Vibha,, Frohnert, Brigitte I.,, Ghosh, Soumya,, Kwon, Bum Chul,, Lund University., Lund University., Lundgren, Markus,, Ng, Kenney,, Severson, Kristen A.,, Sun, Zhaonan,   +9 more
core   +1 more source

Sub-national levels and trends in contraceptive prevalence, unmet need, and demand for family planning in Nigeria with survey uncertainty

BMC Public Health, 2019
Background Ambitious global goals have been established to provide universal access to affordable modern contraceptive methods. To measure progress toward such goals in populous countries like Nigeria, it’s essential to characterize the current levels ...
Laina D. Mercer, Fred Lu, Joshua L. Proctor   +2 more
doaj   +1 more source

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling [PDF]

, 2011
The failure of biology to identify the molecular causes of disease has led to disappointment in the rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes ...
Christine Suver, David Henderson, Jonathan Derry, Jonathan Derry, Jonathan Izant, Lara Mangravite, Matt Furia, Michael Kellen, Solveig Sieberts, Stephen Friend, Xavier Schildwachter   +10 more
core   +2 more sources

Effectiveness of reactive case detection for malaria elimination in three archetypical transmission settings: a modelling study

Malaria Journal, 2017
Background Reactive case detection could be a powerful tool in malaria elimination, as it selectively targets transmission pockets. However, field operations have yet to demonstrate under which conditions, if any, reactive case detection is best poised ...
Jaline Gerardin, Caitlin A. Bever, Daniel Bridenbecker, Busiku Hamainza, Kafula Silumbe, John M. Miller, Thomas P. Eisele, Philip A. Eckhoff, Edward A. Wenger   +8 more
doaj   +1 more source