Results 21 to 30 of about 7,831,583 (247)
The risk of type 2 oral polio vaccine use in post-cessation outbreak response
BMC Medicine, 2017 Background Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis.
Kevin A. McCarthy +4 more
doaj +1 more source
A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
Cell & Bioscience, 2023 Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD
Jin-Gu Lee +6 more
doaj +1 more source
International Journal of Infectious Diseases, 2021 : Background: The case count for coronavirus disease 2019 (COVID-19) is the predominant measure used to track epidemiological dynamics and inform policy decision-making.
Mollie M. Van Gordon +3 more
doaj +1 more source
Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration
Journal of Translational Medicine, 2021 The skin is made up of a plethora of cells arranged in multiple layers with complex and intricate vascular networks, creating a dynamic microenvironment of cells-to-matrix interactions.
Qian Hua Phua +2 more
doaj +1 more source
3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases
Biomedicines, 2022 The COVID-19 pandemic has driven the scientific community to adopt an efficient and reliable model that could keep up with the infectious disease arms race.
Shirley Pei Shan Chia +3 more
doaj +1 more source
BMC Infectious Diseases, 2018 Background Malaria transmission is both seasonal and heterogeneous, and mathematical models that seek to predict the effects of possible intervention strategies should accurately capture realistic seasonality of vector abundance, seasonal dynamics of ...
Prashanth Selvaraj +2 more
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2023 Methyltransferases regulate transcriptome dynamics during development and aging, as well as in disease. Various methyltransferases have been linked to heart disease, through disrupted expression and activity, and genetic variants associated with ...
Jun-yi Zhu +5 more
doaj +1 more source
BMC Public Health, 2019 Background Ambitious global goals have been established to provide universal access to affordable modern contraceptive methods. To measure progress toward such goals in populous countries like Nigeria, it’s essential to characterize the current levels ...
Laina D. Mercer +2 more
doaj +1 more source
Developing Predictive Molecular Maps of Human Disease through Community-based Modeling [PDF]
, 2011 The failure of biology to identify the molecular causes of disease has led to disappointment in the rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes ...
Solveig K. Sieberts +16 more
core +1 more source
Statistical Disease Progression Modeling in Alzheimer Disease [PDF]
, 2020 BACKGROUND: The characterizing symptom of Alzheimer disease (AD) is cognitive deterioration. While much recent work has focused on defining AD as a biological construct, most patients are still diagnosed, staged, and treated based on their cognitive ...
Alzheimer's Disease Neuroimaging Initiative +1 more
core +1 more source