Results 21 to 30 of about 1,245,538 (288)

Mending a broken heart: current strategies and limitations of cell-based therapy

Stem Cell Research & Therapy, 2020
The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for potential application in regenerative medicine. Over the past decade, the concept of replenishing the
Lee Chuen Liew, Beatrice Xuan Ho, Boon-Seng Soh   +2 more
doaj   +1 more source

Preventing a cluster from becoming a new wave in settings with zero community COVID-19 cases

BMC Infectious Diseases, 2022
Background In settings with zero community transmission, any new SARS-CoV-2 outbreaks are likely to be the result of random incursions. The level of restrictions in place at the time of the incursion is likely to considerably affect possible outbreak ...
Romesh G. Abeysuriya, Dominic Delport, Robyn M. Stuart, Rachel Sacks-Davis, Cliff C. Kerr, Dina Mistry, Daniel J. Klein, Margaret Hellard, Nick Scott   +8 more
doaj   +1 more source

Edge-Based Compartmental Modeling for Infectious Disease Spread Part III: Disease and Population Structure [PDF]

, 2011
We consider the edge-based compartmental models for infectious disease spread introduced in Part I. These models allow us to consider standard SIR diseases spreading in random populations.
Alain Barrat, C Bauch, C Pilcher, E Volz, EM Volz, Erik M. Volz, F Ball, F Ball, F Ball, F Ball, J Lindquist, J Parsons, J Wallinga, JC Miller, JC Miller, JC Miller, JC Miller, JC Miller, JC Miller, JO Lloyd-Smith, Joel C. Miller, K Dietz, K Dietz, K Eames, K Eames, K Sharkey, L Decreusefond, LA Meyers, M Altmann, M Molloy, MEJ Newman, MEJ Newman, O Diekmann, R Pastor-Satorras, RM May, RM May, T House, T House, Y Moreno   +38 more
core   +2 more sources

Modeling anticipated changes in numbers of SARS-CoV-2 infections within communities due to immunization campaigns [version 2; peer review: 2 approved]

Gates Open Research, 2022
Background: As SARS-CoV-2 spread in early 2020, uncertainty about the scope, duration, and impact of the unfolding outbreaks caused numerous countries to interrupt many routine activities, including health services.
Brittany Hagedorn, Kurt Frey, Susan Annemarie Wang, Kevin A. McCarthy, Raymond Hutubessy   +4 more
doaj   +1 more source

Spatial clustering of average risks and risk trends in Bayesian disease mapping [PDF]

, 2016
Spatiotemporal disease mapping focuses on estimating the spatial pattern in disease risk across a set of nonoverlapping areal units over a fixed period of time.
Anderson, Craig, Dean, Nema, Lee, Duncan
core   +1 more source

Potential health and economic impact of paediatric vaccination using next-generation influenza vaccines in Kenya: a modelling study

BMC Medicine, 2023
Background Influenza is a major year-round cause of respiratory illness in Kenya, particularly in children under 5. Current influenza vaccines result in short-term, strain-specific immunity and were found in a previous study not to be cost-effective in ...
Naomi R. Waterlow, Sreejith Radhakrishnan, Jeanette Dawa, Edwin van Leeuwen, Simon R. Procter, Philipp Lambach, Joseph Bresee, Marie Mazur, Rosalind M. Eggo, Mark Jit   +9 more
doaj   +1 more source

A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features

Human Genomics, 2018
Background Intellectual disability (ID) is a common condition with a population prevalence frequency of 1–3% and an enrichment for males, driven in part by the contribution of mutant alleles on the X-chromosome.
Georgios Kellaris, Kamal Khan, Shahid M. Baig, I-Chun Tsai, Francisca Millan Zamora, Paul Ruggieri, Marvin R. Natowicz, Nicholas Katsanis   +7 more
doaj   +1 more source

Constructing Ontology-Based Cancer Treatment Decision Support System with Case-Based Reasoning [PDF]

, 2018
Decision support is a probabilistic and quantitative method designed for modeling problems in situations with ambiguity. Computer technology can be employed to provide clinical decision support and treatment recommendations.
Colloc, Joël, Guo, Ziyi, Jacquet-Andrieu, Armelle, Liu, Yong, Shen, Ying   +4 more
core   +2 more sources

Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome

Human Genomics, 2017
Background The ciliopathies represent an umbrella group of >50 clinical entities that share both clinical features and molecular etiology underscored by structural and functional defects of the primary cilium. Despite the advances in gene discovery, this
Benjamin M. Helm, Jason R. Willer, Azita Sadeghpour, Christelle Golzio, Eric Crouch, Samantha Schrier Vergano, Nicholas Katsanis, Erica E. Davis   +7 more
doaj   +1 more source

Generation and quality control of lipidomics data for the alzheimers disease neuroimaging initiative cohort. [PDF]

, 2018
Alzheimers disease (AD) is a major public health priority with a large socioeconomic burden and complex etiology. The Alzheimer Disease Metabolomics Consortium (ADMC) and the Alzheimer Disease Neuroimaging Initiative (ADNI) aim to gain new biological ...
AA Willette, B De Strooper, CA McLean, CC Liu, CR Jack Jr., CS McCoin, DA Butterfield, F Picconi, F Zhu, G McKhann, G Verdile, H Tsugawa, J Fahrmann, J Gotz, JM Weir, KH Ashe, KP Ng, L St John-Williams, MG Spillantini, MR Wenk, MR Wenk, MW Weiner, MW Weiner, MW Wong, O Quehenberger, P Edison, P Proitsi, P Proitsi, R Kaddurah-Daouk, R Ossenkoppele, RC Petersen, S Kullmann, SG Mueller, SM de la Monte, SN Jackson, T Cajka, T Cajka, T Cajka, T Cajka, T Kind, TJ Montine, X Han, Y Huang   +42 more
core   +2 more sources