Results 21 to 30 of about 565,742 (268)
Mending a broken heart: current strategies and limitations of cell-based therapy
Stem Cell Research & Therapy, 2020 The versatility of pluripotent stem cells, attributable to their unlimited self-renewal capacity and plasticity, has sparked a considerable interest for potential application in regenerative medicine. Over the past decade, the concept of replenishing the
Lee Chuen Liew +2 more
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Preventing a cluster from becoming a new wave in settings with zero community COVID-19 cases
BMC Infectious Diseases, 2022 Background In settings with zero community transmission, any new SARS-CoV-2 outbreaks are likely to be the result of random incursions. The level of restrictions in place at the time of the incursion is likely to considerably affect possible outbreak ...
Romesh G. Abeysuriya +8 more
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Perspective: A model disease [PDF]
Nature, 2011 Despite its rarity, multiple myeloma is an ideal testing ground for cancer biology, says William Matsui.
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Gates Open Research, 2022 Background: As SARS-CoV-2 spread in early 2020, uncertainty about the scope, duration, and impact of the unfolding outbreaks caused numerous countries to interrupt many routine activities, including health services.
Brittany Hagedorn +4 more
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BMC Medicine, 2023 Background Influenza is a major year-round cause of respiratory illness in Kenya, particularly in children under 5. Current influenza vaccines result in short-term, strain-specific immunity and were found in a previous study not to be cost-effective in ...
Naomi R. Waterlow +9 more
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Cellular models of Batten disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020 The Neuronal Ceroid Lipofuscinoses (NCL), otherwise known as Batten disease, are a group of neurodegenerative diseases caused by mutations in 13 known genes. All except one NCL is autosomal recessive in inheritance, with similar aetiology and characterised by the accumulation of autofluorescent storage material in the lysosomes of cells.
Minnis, CJ +3 more
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Parathyroid Diseases and Animal Models [PDF]
Frontiers in Endocrinology, 2012 CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). PTH acts to stimulate a rapid increment in serum calcium and has a crucial role in calcium homeostasis. Major target organs of PTH are kidney and bone.
Imanishi, Yasuo +2 more
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Human Genomics, 2018 Background Intellectual disability (ID) is a common condition with a population prevalence frequency of 1–3% and an enrichment for males, driven in part by the contribution of mutant alleles on the X-chromosome.
Georgios Kellaris +7 more
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Human Genomics, 2017 Background The ciliopathies represent an umbrella group of >50 clinical entities that share both clinical features and molecular etiology underscored by structural and functional defects of the primary cilium. Despite the advances in gene discovery, this
Benjamin M. Helm +7 more
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Fitting homocysteine to disease models, as well as adjusting the models to the disease [PDF]
Journal of Molecular Medicine, 2015 Homocysteine is a nonprotein α-amino acid and differs from cysteine by having an additional methylene bridge. Homocysteine is not present in the diet, and all homocysteine in the body is biosynthesized from the essential amino acid methionine. Homocysteine is a product of methionine demethylation and is recycled into methionine or alternatively ...
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