Identification of Bipotential Blood Cell/Nephrocyte Progenitors in Drosophila: Another Route for Generating Blood Progenitors [PDF]
Frontiers in Cell and Developmental Biology, 2022 The Drosophila lymph gland is the larval hematopoietic organ and is aligned along the anterior part of the cardiovascular system, composed of cardiac cells, that form the cardiac tube and its associated pericardial cells or nephrocytes.
Ismael Morin-Poulard +2 more
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APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway [PDF]
DMM Disease Models and Mechanisms, 2023 Jun-Yi Zhu, Jin-Gu Lee, Yulong Fu
exaly +4 more sources
HIV-1 Nef synergizes with APOL1-G1 to induce nephrocyte cell death in HIV-related kidney diseases [PDF]
DMM Disease Models and MechanismsJun-Yi Zhu +2 more
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Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes [PDF]
eLife, 2022 The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component.
Konrad Lang +12 more
doaj +2 more sources
mTOR-Dependent Autophagy Regulates Slit Diaphragm Density in Podocyte-like Drosophila Nephrocytes [PDF]
Cells, 2022 Both mTOR signaling and autophagy are important modulators of podocyte homeostasis, regeneration, and aging and have been implicated in glomerular diseases.
Dominik Spitz +6 more
doaj +2 more sources
Actin Cytoskeleton and Integrin Components Are Interdependent for Slit Diaphragm Maintenance in Drosophila Nephrocytes [PDF]
CellsIn nephrotic syndrome, the podocyte filtration structures are damaged in a process called foot process effacement. This is mediated by the actin cytoskeleton; however, which actins are involved and how they interact with other filtration components, like
Megan Delaney +4 more
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A protective role for Drosophila Filamin in nephrocytes via Yorkie mediated hypertrophy [PDF]
Life Science Alliance, 2022 Nephrocytes lacking key components of the filtration barrier respond by increasing Drosophila Filamin expression, which accumulates at the cell cortex to elicit a protective role.
Sybille Koehler +2 more
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Piezo activity levels need to be tightly regulated to maintain normal morphology and function in pericardial nephrocytes [PDF]
Scientific ReportsDue to their position on glomerular capillaries, podocytes are continuously counteracting biomechanical filtration forces. Most therapeutic interventions known to generally slow or prevent the progression of chronic kidney disease appear to lower these ...
Kristina Schulz +8 more
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Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity [PDF]
Frontiers in Cell and Developmental Biology, 2022 Glomerular podocytes build, with their intercellular junctions, part of the kidney filter. The podocyte cell adhesion protein, nephrin, is essential for developing and maintaining slit diaphragms as functional loss in humans results in heavy proteinuria.
Mee-Ling Maywald +9 more
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Translocation of gut bacteria promotes tumor-associated mortality by inducing immune-activated renal damage [PDF]
The EMBO JournalParaneoplastic syndrome represents severe and complex systemic clinical symptoms manifesting in multiple organs of cancer patients, but its cause and cellular underpinnings remain little explored.
Fei Cong +9 more
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