Results 1 to 10 of about 7,412 (180)

Advances in slit diaphragm signaling

Current Opinion in Nephrology and Hypertension, 2014
The podocyte slit diaphragm is a fundamental component of the glomerular filtration barrier and its function is highly dependent on the maintenance of specialized actin-based projections known as foot processes. In this review, we update the function of key slit diaphragm-associated proteins, and introduce some new players and emerging avenues of ...
Laura A, New, Claire E, Martin, Nina, Jones   +2 more
openaire   +2 more sources

ER stress and slit diaphragms: is there a connection?

Kidney International, 2023
Galloway-Mowat syndrome is a neurorenal syndrome that has been linked with defective transfer RNA and protein translation caused by variants in the multiprotein complex KEOPS. In the kidney, this syndrome seems to primarily affect the podocytes, but the pathogenesis has remained unclear. In this issue of Kidney International, Krausel et al.
Hermle, Tobias, Simons, Matias
openaire   +3 more sources

Molecular structure-function relationship in the slit diaphragm

Seminars in Nephrology, 2003
The past 5 years have witnessed an exponential increase in our understanding of the structure and function of the glomerular slit diaphragm. The identification of nephrin as the first transmembrane slit diaphragm protein was a watershed event in slit diaphragm biology.
Sumant S, Chugh, Beenu, Kaw, Yashpal S, Kanwar   +2 more
openaire   +2 more sources

Clinical impact of research on the podocyte slit diaphragm

Nature Clinical Practice Nephrology, 2006
This Review summarizes recent research on the podocyte slit diaphragm. A growing number of molecules that function at the slit diaphragm have been identified in patients with inherited and sporadic nephrotic syndromes. Genetic deletion of nearly all of these molecules results in proteinuria and effacement of foot processes.
Duncan B, Johnstone, Lawrence B, Holzman
openaire   +2 more sources

The molecular architecture of the kidney slit diaphragm

2023
Abstract Vertebrate life depends on renal function to filter excess fluid and remove low-molecular-weight waste products. An essential component of the kidney filtration barrier is the slit diaphragm (SD), a specialized cell-cell junction between podocytes.
Alexandra N. Birtasu, Konstantin Wieland, Utz H. Ermel, Johanna V. Rahm, Margot P. Scheffer, Benjamin Flottmann, Mike Heilemann, Florian Grahammer, Achilleas S. Frangakis   +8 more
openaire   +1 more source

Slit Diaphragm Junctional Complex and Regulation of the Cytoskeleton

Nephron Experimental Nephrology, 2007
In recent years, identification of proteins found at the slit diaphragm has greatly improved our understanding of the molecular mechanisms responsible for forming and maintaining the glomerular filtration barrier. This review examines the function of proteins identified at the podocyte intercellular junction in coordinating podocyte intercellular ...
Puneet, Garg, Rakesh, Verma, Lawrence B, Holzman   +2 more
openaire   +2 more sources

The slit diaphragm: a signaling platform to regulate podocyte function

Current Opinion in Nephrology and Hypertension, 2005
The discovery of nephrin and other slit diaphragm proteins dramatically expanded our knowledge of the molecular make-up of the glomerular filter of the kidney. This review focuses on the most recent evidence elucidating the dynamic functions of the slit diaphragm and stresses the importance of slit diaphragm proteins in mediating signal transduction in
Huber, Tobias B., Benzing, Thomas
openaire   +3 more sources

SIRPα interacts with nephrin at the podocyte slit diaphragm

The FEBS Journal, 2012
The slit diaphragm (SD) is an intercellular junction between renal glomerular epithelial cells (podocytes) that is essential for permselectivity in glomerular ultrafiltration. The SD components, nephrin and Neph1, assemble a signaling complex in a tyrosine phosphorylation dependent manner, and regulate the unique actin cytoskeleton of podocytes ...
Yuko, Kajiho, Yutaka, Harita, Hidetake, Kurihara, Shigeru, Horita, Atsuko, Matsunaga, Haruko, Tsurumi, Shoichiro, Kanda, Noriko, Sugawara, Kenichiro, Miura, Takashi, Sekine, Seisuke, Hattori, Motoshi, Hattori, Takashi, Igarashi   +12 more
openaire   +2 more sources

Role of podocyte slit diaphragm as a filtration barrier.

Nephrology (Carlton, Vic.), 2007
Although the role of glomerular basement membrane has been emphasised as the barrier for retaining plasma proteins in the past three decades, some recent studies have demonstrated that the slit diaphragm of the glomerular epithelial cell (podocyte) is the structure likely to be the barrier in the glomerular capillary wall.
Hiroshi, Kawachi, Naoko, Miyauchi, Koichi, Suzuki, Gi Dong, Han, Michiaki, Orikasa, Fujio, Shimizu   +5 more
openaire   +2 more sources

Slit Diaphragms: Junctions That Never Sleep

Journal of the American Society of Nephrology, 2022
openaire   +2 more sources