Results 1 to 10 of about 8,883 (209)

Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro. [PDF]

PLoS ONE, 2016
Nephrin is expressed at the basolateral aspect of podocytes and is an important signaling protein at the glomerular slit diaphragm. In vitro studies have demonstrated that Nephrin phosphorylation-dependent signaling is able to assemble a protein complex ...
Rakesh Verma, Madhusudan Venkatareddy, Anne Kalinowski, Sanjeevkumar R Patel, Puneet Garg   +4 more
doaj   +2 more sources

Serum Nephrin Levels in Severe Preeclampsia: A Cross-Sectional Study

Indonesian Journal of Obstetrics and Gynecology, 2021
Objective: To determine differences in serum nephrin levels in severe preeclampsia compared to normal pregnancy and also its correlation with systolic and diastolic blood pressure and proteinuria.
Meice Fitrina, Sofie R. Krisnadi, Hartanto Bayuaji   +2 more
doaj   +3 more sources

It's not all about nephrin [PDF]

Kidney International, 2008
Mutations in the NPHS1 gene cause congenital nephrotic syndrome of the Finnish type. The gene product nephrin is a structural component of the glomerular slit diaphragm formed by neighboring podocytes. Nephrin has also been suggested to be involved in signaling processes that are important for podocyte survival and differentiation.
Simons, Matias, Huber, Tobias B.
openaire   +3 more sources

Characterization of a novel disease-associated mutation within NPHS1 and its effects on nephrin phosphorylation and signaling. [PDF]

PLoS ONE, 2018
Mutations in the transmembrane protein nephrin (encoded by NPHS1) underlie nearly half of all cases of congenital nephrotic syndrome (CNS), which is caused by aberrations in the blood filtering function of glomerular podocytes.
C James Cooper, Nikkita T Dutta, Claire E Martin, Tino D Piscione, Paul S Thorner, Nina Jones   +5 more
doaj   +2 more sources

Effect of Steroids on Anti-nephrin Autoantibodies and B cells in Minimal Change Disease [PDF]

Kidney International Reports
Introduction: The identification of autoantibodies against nephrin, a key signaling protein of the podocyte slit diaphragm, and their pathogenic role in patients with minimal change disease (MCD) has substantially changed our understanding of primary ...
Felicitas E. Hengel, Asma Beldi-Ferchiou, Hamza Sakhi, Nastassia Liaukouskaya, Silke Dehde, Alexandre Karras, Emmanuel Esteve, Julie Oniszczuk, Sabine Le Gouvello, Luis Herrera-Marcos, Nizar Joher, Eric Daugas, Mohamad Zaidan, Khalil El Karoui, Bertrand Knebelmann, Myriam Dao, Anissa Moktefi, Dil Sahali, Tobias B. Huber, Mario Ollero, Nicola M. Tomas, Vincent Audard   +21 more
doaj   +2 more sources

Establishment of Nephrin Reporter Mice and Use for Chemical Screening. [PDF]

PLoS ONE, 2016
Nephrin is a critical component of glomerular filtration barrier, which is important to maintain glomerular structure and avoid proteinuria. Downregulation of nephrin expression is commonly observed at early stage of glomerular disorders, suggesting that
Junichi Tsuchida, Taiji Matsusaka, Masato Ohtsuka, Hiromi Miura, Yukiko Okuno, Katsuhiko Asanuma, Takahiko Nakagawa, Motoko Yanagita, Kiyoshi Mori   +8 more
doaj   +3 more sources

Inducible Nephrin Transgene Expression in Podocytes Rescues Nephrin-Deficient Mice from Perinatal Death [PDF]

The American Journal of Pathology, 2010
Mutations leading to nephrin loss result in massive proteinuria both in humans and mice. Early perinatal lethality of conventional nephrin knockout mice makes it impossible to determine the role of nephrin protein in the adult kidney and in extra-renal tissues.
Juhila, J., Lassila, M., Roozendaal, R., Lehtonen, E., Messing, M., Langer, B., Kerjaschki, D., Verbeek, J.S., Holthofer, H.   +8 more
openaire   +4 more sources

Nephrin and endothelial injury

Current Opinion in Nephrology & Hypertension, 2009
Nephrin, the main structural protein of the slit diaphragm, is expressed on the surface of glomerular podocytes and is critical in maintaining permselectivity and preventing proteinuria. This review focuses on the fate of nephrin in the context of endothelial injury and gives an update on the recent progress in understanding the pathomechanisms that ...
Hauser P. V., Collino F., Bussolati B., Camussi G.   +3 more
openaire   +4 more sources

Association between anti-nephrin autoantibodies and disease activity in minimal change disease [PDF]

Annals of Medicine
Background Minimal change disease (MCD) is a podocytopathy linked to immune-mediated mechanisms, with emerging evidence suggesting the presence of anti-nephrin autoantibodies in a subset of patients.
Ming Guo, Lei Yan, Jiagen Zhao, Xiaoxiao Liu, Haiyu Zhang, Mengfei Li, Keyi Zhang, Jing Cui, Yong Wang, Xiangmei Chen, Zheyi Dong, Qinggang Li   +11 more
doaj   +2 more sources

Nephrin – a biomarker of early glomerular injury [PDF]

Biomarker Research, 2014
Nephrin is a 180 KD trans-membrane protein expressed in glomerular podocytes. It was first identified in children with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin forms an integral part of podocytes, which-together with endothelial cells and the basement-form the glomerular filtration barrier.
Kandasamy, Yogavijayan, Smith, Roger, Lumbers, Eugenie R., Rudd, Donna   +3 more
openaire   +5 more sources