Results 31 to 40 of about 8,883 (209)

Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure

Cell Reports, 2012
Robo2 is the cell surface receptor for the repulsive guidance cue Slit and is involved in axon guidance and neuronal migration. Nephrin is a podocyte slit-diaphragm protein that functions in the kidney glomerular filtration barrier.
Xueping Fan, Qinggang Li, Anna Pisarek-Horowitz, Hila Milo Rasouly, Xiangling Wang, Ramon G. Bonegio, Hang Wang, Margaret McLaughlin, Steve Mangos, Raghu Kalluri, Lawrence B. Holzman, Iain A. Drummond, Dennis Brown, David J. Salant, Weining Lu   +14 more
doaj   +1 more source

Cloning and Expression of the Rat Nephrin Homolog [PDF]

The American Journal of Pathology, 1999
Despite of the increased availability of genetically modified mouse strains, the experimental models in the rat have provided the most widely employed and versatile models for the study of renal pathophysiology and functional genetics. The identification of the human gene mutated in the congenital nephrotic syndrome of the Finnish type (NPHS1) has ...
H, Ahola, S X, Wang, P, Luimula, M L, Solin, L B, Holzman, H, Holthöfer   +5 more
openaire   +2 more sources

Interaction with Podocin Facilitates Nephrin Signaling [PDF]

Journal of Biological Chemistry, 2001
Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. In addition, mice lacking CD2-associated protein (CD2AP) develop a nephrotic syndrome that resembles NPHS mutations suggesting that all three proteins are essential for the integrity of glomerular podocytes ...
Huber, Tobias B., Köttgen, Michael, Schilling, Birgit, Walz, Gerd, Benzing, Thomas   +4 more
openaire   +3 more sources

Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.

PLoS ONE, 2011
Actin dynamics has emerged at the forefront of podocyte biology. Slit diaphragm junctional adhesion protein Nephrin is necessary for development of the podocyte morphology and transduces phosphorylation-dependent signals that regulate cytoskeletal ...
Madhusudan Venkatareddy, Leslie Cook, Kamal Abuarquob, Rakesh Verma, Puneet Garg   +4 more
doaj   +1 more source

Tissue Expression of Nephrin in Human and Pig [PDF]

Pediatric Research, 2004
Nephrin is a major component of the glomerular filtration barrier. Mutations in the nephrin gene (NPHS1) are responsible for congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrin was at first thought to be podocyte specific, but recent studies have suggested that nephrin is also expressed in nonrenal tissues such as pancreas and CNS.
Arvi-Matti, Kuusniemi, Marjo, Kestilä, Jaakko, Patrakka, Anne-Tiina, Lahdenkari, Vesa, Ruotsalainen, Christer, Holmberg, Riitta, Karikoski, Riitta, Salonen, Karl, Tryggvason, Hannu, Jalanko   +9 more
openaire   +2 more sources

Elevated Levels of Urinary Podocyte-Derived Microparticles in Nephrotic Syndrome

Indonesian Biomedical Journal, 2023
BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular disease in childhood. The proposed hypothesis for the pathogenesis of this disease has changed over time, from immune dysregulation theory and systemic circulating factors theory, to the ...
Eka Laksmi Hidayati, Bambang Supriyatno, Sudung Oloan Pardede, Partini Pudjiastuti Trihono, Dewi Sukmawati, Dewi Wulandari, Oke Rina Ramayani   +6 more
doaj   +1 more source

Life Without Nephrin [PDF]

Journal of the American Society of Nephrology, 2012
It is difficult to conceive how podocytes establish slit diaphragms without nephrin, but a recent paper1 suggests that an entire class of vertebrates have podocytes that are able to do just that. Why did this discovery take so long, and why should it be surprising or exciting?
openaire   +2 more sources

Expression of Nephrin in Pediatric Kidney Diseases [PDF]

Journal of the American Society of Nephrology, 2001
Abstract. Nephrin is a podocyte cell adhesion protein located at the slit diaphragm area of the kidney glomerulus. Mutations in the nephrin gene (NPHS1) lead to congenital nephrosis, suggesting that nephrin is essential for the glomerular filtration barrier.
Jaakko, Patrakka, Vesa, Ruotsalainen, Ilkka, Ketola, Christer, Holmberg, Markku, Heikinheimo, Karl, Tryggvason, Hannu, Jalanko   +6 more
openaire   +2 more sources

Recombinant erythropoietin treatment improves serum podocyte marker levels in diabetic kidney disease

Advances in Biomarker Sciences and Technology, 2023
Background: Recombinant human erythropoietin (rHuEPO) is an effective treatment for renal anemia. Recently, there is evidence to suggest that rHuEPO may reduce podocyte injury in diabetic kidney disease (DKD).
Lingfeng Zeng, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Cheuk-Chun Szeto   +5 more
doaj   +1 more source

Characteristics of polyclonal anti-human nephrin antibodies induced by genetic immunization using nephrin cDNA [PDF]

Nephrology Dialysis Transplantation, 2006
Nephrin is an essential protein for maintaining the normal structure of the podocyte foot process and the glomerular filtration barrier. To analyse the mechanism of proteinuria and treatment of nephrotic syndrome, we produced and characterized polyclonal anti-human nephrin antibodies using a newly developed genetic immunization technique.An expression ...
Togo, Aoyama, Kouju, Kamata, Nozomu, Yamanaka, Yasuo, Takeuchi, Masaaki, Higashihara, Seishi, Kato   +5 more
openaire   +2 more sources