Posttranslational microtubule modification alters podocalyxin-trafficking in epithelial cells [PDF]
Frontiers in Cell and Developmental BiologyEpithelial polarization is characterized by separation of the plasma membrane into an apical and a basolateral membrane domain. This morphology is verified by cytoskeletal organization that stabilizes the cellular architecture and provides specific ...
Lena-Sophie Gorek +6 more
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Podocalyxin Is a Marker of Poor Prognosis in Pancreatic Ductal Adenocarcinoma. [PDF]
PLoS ONE, 2015 Podocalyxin-like 1 is a transmembrane glyco-protein whose overexpression associates in many cancers with poor prognosis and unfavorable clinicopathological characteristics.
Kapo Saukkonen +8 more
doaj +5 more sources
Dynamics and Predictive Values of Urinary Podocyte Biomarkers Following SGLT2 Inhibition in CKD [PDF]
LifePodocyte injury is an early hallmark of chronic kidney disease (CKD) and can be influenced by SGLT2 inhibitors (SGLT2i). Early effects of SGLT2i include transient estimated glomerular filtration rate (eGFR) dip and reduced proteinuria; however, the ...
Alexandra Urs +10 more
doaj +2 more sources
Serum Podocalyxin Level as a Potential Biomarker for Diagnosis of Nephrotic Syndrome and Prediction of Steroid Response [PDF]
Medeniyet Medical JournalObjective: Idiopathic nephrotic syndrome (NS) is a common pediatric glomerular disorder. Podocyte damage constitutes a central mechanism in its pathophysiology.
Emre LEVENTOGLU +2 more
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Utility of urinary podocalyxin levels in patients with and without type 2 diabetic nephropathy and its correlation with renal function [PDF]
BMC Research NotesPurpose Podocalyxin is a urinary protein that may serve as a potential indicator for the early detection of diabetic nephropathy. The objectives of this study were to assess urinary podocalyxin levels in patients with and without type 2 diabetic ...
Jothivanan Perumal +2 more
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Podocyte Markers as Diagnostic Biomarkers of Diabetic Nephropathy: A Case–Control Comparison to Haemato‐Biochemical Markers in a Ghanaian Population [PDF]
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.This study shows that urinary nephrin and related podocyte injury markers are elevated among people living with diabetes in Ghana, particularly those with macroalbuminuria. Nephrin demonstrated discriminatory ability, supporting its role as an exploratory biomarker for diabetic nephropathy rather than a standalone diagnostic tool.
Helen Owusu‐Asante +3 more
wiley +2 more sources
Urinary vesicle biomarkers and kidney function—results from the German AugUR study [PDF]
Scientific ReportsProgression into more severe stages of chronic kidney disease (CKD) based on estimated glomerular filtration rate (eGFR) and albuminuria are associated with increased risk of end-stage renal failure, cardiovascular diseases, and mortality.
Luisa Schnobrich +8 more
doaj +2 more sources
Podocalyxin and kidney diseases [PDF]
The Ukrainian Biochemical JournalSelectivity of blood filtration by the renal glomerulus is largely determined by the presence in its visceral epithelium of the terminally differentiated “octopus-like” cells called podocytes.
I. Kostovska
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Requirement of podocalyxin in TGF-beta induced epithelial mesenchymal transition. [PDF]
PLoS ONE, 2011 Epithelial mesenchymal transition (EMT) is characterized by the development of mesenchymal properties such as a fibroblast-like morphology with altered cytoskeletal organization and enhanced migratory potential.
Xiaobo Meng +2 more
doaj +3 more sources
Value of immunohistochemical expression of podocalyxin in active lupus nephritis
Nefrología (English Edition), 2018 Podocalyxin is an electronegative sialoglycoprotein that prevents the podocyte foot process from collapsing. The aim of this study was to detect an association between the glomerular immunohistochemical (IHC) expression of podocalyxin and the degree of ...
Maha Abdelmoneim Behairy +3 more
doaj +7 more sources