Results 1 to 10 of about 899,728 (258)

Podocyte injury damages podocytes in chimeric organoids. [PDF]

PLoS One
Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenitor cells of two mouse lines: one expressing a receptor for a ...
Udagawa T, Araoka T, Osafune K, Matsusaka T.   +3 more
europepmc   +3 more sources

MicroRNAs in Podocyte Injury in Diabetic Nephropathy [PDF]

Frontiers in Genetics, 2020
Diabetic nephropathy is one of the major complications of diabetes mellitus and is the leading cause of end-stage renal disease worldwide. Podocyte injury contributes to the development of diabetic nephropathy.
Hiroki Ishii, Shohei Kaneko, Katsunori Yanai, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita   +7 more
doaj   +5 more sources

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Genes and Diseases, 2022
Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen, Chunhua Weng, Yucheng Wang, Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen   +9 more
doaj   +3 more sources

Podocyte injury and its consequences [PDF]

Kidney International, 2016
Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends on their highly differentiated postmitotic phenotype, which also defines the particular vulnerability of the glomerulus. Recent podocyte biology and gene disruption studies in vivo indicate a causal relationship between abnormalities of single podocyte ...
Michio Nagata
exaly   +3 more sources

Urinary ANGPTL3: a novel noninvasive biomarker for podocyte injury in pediatric glomerular diseases [PDF]

Journal of Translational Medicine
Background Podocyte injury constitutes the pathological basis of various glomerular diseases; however noninvasive tools for assessing podocyte injury remain limited.
Hengmin Wang, Jiaojiao Liu, Rufeng Dai, Chunyan Wang, Xiaotian Chen, Xin Wang, Jialu Liu, Xiaoshan Tang, Xinli Han, Yihui Zhai, Qian Shen, Hong Xu   +11 more
doaj   +2 more sources

Knowledge Domain and Emerging Trends in Podocyte Injury Research From 1994 to 2021: A Bibliometric and Visualized Analysis

Frontiers in Pharmacology, 2021
Background: Podocyte injury has a direct causal relationship with proteinuria and glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression. Podocyte injury plays a critically decisive role in the development of proteinuric
Tongtong Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Yongli Zhan   +5 more
doaj   +3 more sources

Mechanisms of Podocyte Injury in Kidney Allografts. [PDF]

Kidney360
Long-term kidney allograft survival remains an important clinical challenge. Although immune-mediated injury, particularly antibody mediated rejection, is associated with long-term graft loss, nonimmune mechanisms also drive chronic allograft failure.
Barsotti GC, Menon MC, Naik A, Rao A.
europepmc   +3 more sources

Extracellular vesicle-derived TMEM106A participated in podocyte injury via EGR1 in preeclampsia [PDF]

Cellular and Molecular Life Sciences
Preeclampsia (PE), a pregnancy-specific hypertensive disorder affecting approximately 5–8% of pregnancies, is a leading cause of maternal and fetal morbidity and mortality.
Dongdong Zhang, Ning Shen, Xia Zhang, Zhitao Zeng, Jiazhen Shang, Shouyu Chai, Xincong Lv, Xueli Zhang, Minghua Fan   +8 more
doaj   +2 more sources

TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease [PDF]

Cell Death Discovery
Exosomes are extracellular vesicles involved in mediating cell–cell communication by shuttling genetic information and proteins. Here, we investigated whether glomerular endothelial cells-derived exosomes play a central role in mediating podocyte injury ...
Yuexin Tian, Yunhe Liu, Xiaojuan Feng, Lunbi Wu, Weiwei Song, Tongyu Zhao, Jinxi Liu, Xinyan Miao, Haimin Ma, Baiyun Jia, Lihua Kang, Qingjuan Liu, Wei Zhang, Huifang Guo, Lin Yang, Jinsheng Xu, Shuxia Liu   +16 more
doaj   +2 more sources

Urinary detection of podocyte injury

Biomedicine and Pharmacotherapy, 2007
Glomerular epithelial cell (podocyte) biology has been focused on in the last few years. The emerging understanding in podocyte biology has improved the molecular mechanism knowledge in many glomerular diseases. Urinary podocyte count and measurement of urinary podocyte specific markers (nephrin and podocalyxin) have been developed to detect podocyte ...
exaly   +4 more sources