Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]
PLoS ONE, 2012 BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu +17 more
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Frontiers in Pharmacology, 2022 Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as “podocyte disease.” There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations.
Lirong Lin +5 more
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Cytokines and podocyte injury: the mechanism of fibroblast growth factor 2-induced podocyte injury [PDF]
Nephrology Dialysis Transplantation, 1999 Our study is designed to find what promotes the of adhesive lesions due to proliferation of epithelial proliferation of epithelial cells in Bowman’s capsule. cells of Bowman’s capsule, since FGF2 administration It has been reported recently that fibroblast growth caused an increase in PCNA-positive epithelial cells of factor 2 ( FGF2) has a ...
T, Sasaki, H, Hatta, G, Osawa
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Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Liliana Schäfer +42 more
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Role of Podocyte Injury in Glomerulosclerosis [PDF]
, 2019 Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to a living environment of various stresses and pathological stimuli, podocytes are prone to injuries; moreover, as a cell without proliferative potential, loss of podocytes is vital in the pathogenesis of glomerulosclerosis.
Lu, Chen-Chen +6 more
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Fatty acids and their metabolism critically regulate podocyte survival [PDF]
, 2014 Diabetic nephropathy (DN) is the most common cause of end-stage renal disease in industrialized countries, and most affected patients have type 2 diabetes.
Kampe, Kapil Dev
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Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
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A new outlook towards kidney injuries [PDF]
, 2012 Acute and chronic progression of injury to the kidney leads to the failure of the renal system and has become an increasingly important cause of morbidity and mortality.
Mahesh Satwekar, Abhijeet Satwekar
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Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway, resulting in reduced podocyte injury. [PDF]
PLoS ONE, 2013 The podocyte functions as a glomerular filtration barrier. Autophagy of postmitotic cells is an important protective mechanism that is essential for maintaining the homeostasis of podocytes. Exploring an in vivo rat model of passive Heymann nephritis and
Lingling Wu +10 more
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Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury [PDF]
Kidney Diseases, 2020 <b><i>Background:</i></b> Levels of urinary microvesicles, which are increased during various kidney injuries, have diagnostic potential for renal diseases. However, the significance of urinary microvesicles as a renal disease indicator is dampened by the difficulty to ascertain their cell source.
Ying Liu +8 more
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