Results 31 to 40 of about 29,045 (218)

MDM2 prevents spontaneous tubular epithelial cell death and acute kidney injury [PDF]

, 2016
Murine double minute-2 (MDM2) is an E3-ubiquitin ligase and the main negative regulator of tumor suppressor gene p53. MDM2 has also a non-redundant function as a modulator of NF-kB signaling. As such it promotes proliferation and inflammation.
Anders, Hans-Joachim, Ebrahim, Martrez, Endlich, Nicole, Fleckinger, Kristina, Kotb, Ahmed M, Li, Moying, Liapis, Helen, Molnar, Jakob, Popper, Bastian, Siegerist, Florian, Thomasova, Dana   +10 more
core   +2 more sources

Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex [PDF]

, 2017
Albumin re-uptake is a receptor-mediated pathway located in renal proximal tubuli. There is increasing evidence of glomerular protein handling by podocytes, but little is known about the mechanism behind this process.
ANGLANI, FRANCA, CEOL, MONICA, DEL PRETE, DORELLA, GIANESELLO, LISA, PRIANTE, GIOVANNA, RADU, CLAUDIA-MARIA, Saleem, Moin A., SIMIONI, PAOLO, TERRIN, LILIANA   +8 more
core   +1 more source

CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]

, 2009
Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Abdel-Aziz, Abdel-Aziz H., Abdel-Bakky, Mohamed Sadek, Amann, Kerstin Ute, Beckmann, Janet, Doberstein, Kai, Doller, Anke, El Sayed, El Sayed M., Gutwein, Paul, Kämpfer-Kolb, Nicole, Pfeilschifter, Josef Martin, Schramme, Anja, Schäfer, Liliana   +11 more
core   +1 more source

Histone deacetylase 9 exacerbates podocyte injury in hyperhomocysteinemia through epigenetic repression of Klotho

Pharmacological Research, 2023
Although hyperhomocysteinemia (hHcys) has been recognized as an important independent risk factor in the progression of end-stage renal disease and the development of cardiovascular complications related to end-stage renal disease, the mechanisms ...
Min Liu, Yang Zhang, Ping Zhan, Wenjuan Sun, Chuanqiao Dong, Xiaohan Liu, Yujie Yang, Xiaojie Wang, Yusheng Xie, Chengjiang Gao, Huili Hu, Benkang Shi, Ziying Wang, Chun Guo, Fan Yi   +14 more
doaj   +1 more source

Research advances on the role of ubiquitin proteasome in podocyte injury of diabetic kidney disease

Linchuang shenzangbing zazhi
Diabetic kidney disease (DKD) is a disease of abnormal renal structure and function due to long-term hyperglycemia. Podocyte injury is a major cause of renal inflammation, glomerular filtration barrier injury and renal fibrosis.
Jin Wang, Wen-ling Dai, Ji-hua Liu
doaj   +1 more source

Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3‐Dependent Podocyte‐Mesenchymal Transition

Advanced Science, 2023
Podocyte injury plays a critical role in the progression of focal segmental glomerulosclerosis (FSGS). Here, it is reported that B‐cell translocation gene 2 (Btg2) promotes Adriamycin (ADR)‐induced FSGS via Smad3‐dependent podocyte‐mesenchymal transition.
Qiong‐ Dan Hu, Hong‐Lian Wang, Jian Liu, Tao He, Rui‐Zhi Tan, Qiong Zhang, Hong‐Wei Su, Fahsai Kantawong, Hui‐Yao Lan, Li Wang   +9 more
doaj   +1 more source

Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]

, 2017
IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna, Delles, Christian, Filip, Szymon, Gakiopoulou, Chara, Jankowski, Joachim, Krochmal, Magdalena, Markoska, Katerina, Mischak, Harald, Orange, Clare, Spasovski, Goce, Vlahou, Antonia, Zoidakis, Jerome   +11 more
core   +2 more sources

Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]

, 2018
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Alex K. Virasami, Aoife M. Waters, Barbaux, Barua, Bharathavikru, Boyer, Bruckner, Bruening, Cassady, Chau, Chen, Cheng, Cheng, Chernin, Chung, Dale Moulding, Denamur, Denys, Eve V. Miller-Hodges, Hartwig, Hastie, Hayashi, Jack Bellerby, Johns, Kakuda, Kann, Klamt, Krebs, Lefebvre, Lipska, Liu, Livak, Mona M. Tahoun, Morimoto, Murea, Neil J. Sebire, Niranjan, O'Brien, Okajima, Patek, Pelletier, Pelletier, Peter Hohenstein, Peter J. Scambler, Piscione, Rheault, Robert D. Sampson, Rowan I. Asfahani, Saran, Schiffer, Shigehara, Sweetwyne, Taelman, Toska, Totaro, Waters, Waters, White, Yang   +58 more
core   +1 more source

Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice

Journal of Diabetes Research, 2021
Objective. Microinflammation plays a crucial role in podocyte dysfunction in diabetic nephropathy, but its regulatory mechanism is still unclear. This study is aimed at discussing the mechanisms underlying the effect of miRNA-155 on podocyte injury to ...
Xiaolei Wang, Yanbin Gao, Wenming Yi, Yu Qiao, Hao Hu, Ying Wang, Yan Hu, Shuxin Wu, Hongfeng Sun, Taojing Zhang   +9 more
doaj   +1 more source

Innate Immune Activity in Glomerular Podocytes [PDF]

, 2017
Glomerular podocytes are specialized in structure and play an essential role in glomerular filtration. In addition, podocyte stress can initiate glomerular damage by inducing the injury of other glomerular cell types.
Hong Xia, Shaolin Shi, Wenduona Bao
core   +1 more source