Results 51 to 60 of about 899,728 (258)
Advanced Science, EarlyView.USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li +10 more
wiley +1 more source
JCI Insight, 2021 The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction.
Jiafa Ren +9 more
doaj +1 more source
Identification of novel podocyte stress-response mechanisms in vitro
, 2019 Although podocyte injury has been correlated with glomerular disease progression, the mechanisms underlying podocyte response to stress in vivo remain poorly understood.
Haley, Kathryn Elizabeth
core +1 more source
Advanced Science, EarlyView.Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang +11 more
wiley +1 more source
A comprehensive insight into autophagy and its potential signaling pathways as a therapeutic target in podocyte injury [PDF]
, 2022 As part of the glomerular filtration membrane, podocyte is terminally differentiated, structurally unique, and highly specialized in maintaining kidney function.
Lim, Soo Kun +2 more
core +3 more sources
Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3‐Dependent Podocyte‐Mesenchymal Transition
Advanced Science, 2023 Podocyte injury plays a critical role in the progression of focal segmental glomerulosclerosis (FSGS). Here, it is reported that B‐cell translocation gene 2 (Btg2) promotes Adriamycin (ADR)‐induced FSGS via Smad3‐dependent podocyte‐mesenchymal transition.
Qiong‐ Dan Hu +9 more
doaj +1 more source
Pharmacological Research, 2023 Although hyperhomocysteinemia (hHcys) has been recognized as an important independent risk factor in the progression of end-stage renal disease and the development of cardiovascular complications related to end-stage renal disease, the mechanisms ...
Min Liu +14 more
doaj +1 more source
Mechanisms of Podocyte Injury in Diabetes [PDF]
Diabetes, 2009 OBJECTIVE We investigated the role of cytochrome P450 of the 4A family (CYP4A), its metabolites, and NADPH oxidases both in reactive oxygen species (ROS) production and apoptosis of podocytes exposed to high glucose and in OVE26 mice, a model of type 1 diabetes ...
Eid, Assaad A. +6 more
openaire +2 more sources
Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria [PDF]
, 2010 Hepatocyte growth factor (HGF) is a potent antifibrotic protein that inhibits kidney fibrosis through several mechanisms. To study its role in podocyte homeostasis, injury, and repair in vivo, we generated conditional knockout mice in which the HGF ...
Liu, Y +10 more
core +1 more source
Advanced Science, EarlyView.This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang +6 more
wiley +1 more source