Results 61 to 70 of about 19,393 (195)

GAP-43 ameliorates Podocyte injury by decreasing nuclear NFATc1 expression

Biochemistry and Biophysics Reports, 2021
Podocyte injury is sufficient to cause glomerulosclerosis and proteinuria, eventually leading to kidney failure. Previous studies found that podocytes and neurons had similar biological characteristics.
Zhiwen Lian, Guibao Ke, Hong Zhang, Caoshuai Dou, Xueqin Chen, Bohou Li, Fengxia Zhang, Shichun Wen, Qiong Wu, Yubin Xia, Nan Jiang, Zhuo Li, Sijia Li, Xingchen Zhao, Jianchao Ma, Ting Lin, Feng Wen, Lixia Xu, Zhilian Li, Huabang Liang, Wei Dong, Yuanhan Chen, Ruizhao Li, Zhiming Ye, Wenjian Wang, Xinling Liang, Wei Shi, Li Zhang, Shuangxin Liu   +28 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

Glomerular subepithelial microparticles - a footprint for podocyte injury

Ultrastructural Pathology, 2021
The aim of this study was to clarify the nature and clinical significance of glomerular subepithelial microparticles (SMPs), located between the basal surface of the podocytes and the glomerular basement membrane. Ultrastructural morphology of 79 renal biopsy samples (obtained from 25 native and 54 transplanted kidneys), showing SMPs in the last 3 ...
Yon Hee, Kim, Kyu Ha, Huh, Beom Jin, Lim, Beom Seok, Kim, Yu Seun, Kim, Soon Il, Kim, Myoung Soo, Kim, Juhan, Lee, Jung Tak, Park, Tae-Hyun, Yoo, Shin-Wook, Kang, Seung Hyeok, Han, Hyeon Joo, Jeong   +12 more
openaire   +3 more sources

Redox‐Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations

Journal of Applied Toxicology, EarlyView.
ABSTRACT Dexamethasone (DEX) is widely used in clinical practice, although it may also cause oxidative stress–related damage in different tissues, including the kidney and male reproductive system. This study investigated DEX‐induced renal and reproductive injury in rats and evaluated the modulatory effect of reduced glutathione on DEX‐associated redox
Caner Öztürk, Neşe Hayat Aksoy, Erkan Özkan, Ayşe Ikinci Keleş, Ahmet Karabulut   +4 more
wiley   +1 more source

Podocyte Infolding Glomerulopathy: A Special Morphology of Podocyte Injury Caused by Heterogeneous Diseases

Kidney International Reports, 2023
Podocyte infolding glomerulopathy (PIG) is a newly recognized rare glomerular injury. The clinical significance and mechanism of this injury pattern remains unclear.We conducted a retrospective study of renal biopsies from January 2018 to December 2020 in Kingmed Diagnostics. The renal biopsy features and clinical data were reviewed.
Ling Hong, Lin Wang, Honglei Wang, Qihua Wang, Shicong Yang, Tian Tian, Tianjiao Cui, Shuling Yue, Xiaotao Hou, Zhihua Zheng, Wenfang Chen   +10 more
openaire   +3 more sources

Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA/PI3K/AKT Pathway

Pediatric Discovery, EarlyView.
MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen, Chenxi Jia, Zhuocheng Shi, Bianan Zhu, Yihang Yu, Xing Liu, Feng Liu, Jianwei Chen, Tao Xu, Yuanyuan Zhang, Deying Zhang, Guanghui Wei   +11 more
wiley   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

The Beneficial Role of Retinoids in Glomerular Disease

Frontiers in Medicine, 2015
The primary etiology of CKD is a direct consequence of initial dysfunction and injury of the glomerulus, the main filtration system. Podocytes are terminally differentiated epithelial cells in the glomerulus, whose major function is the maintenance of ...
Sandeep eMallipattu, John Cijiang He
doaj   +1 more source

Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. [PDF]

PLoS ONE, 2014
Glomerular diseases are commonly characterized by podocyte injury including apoptosis, actin cytoskeleton rearrangement and detachment. However, the strategies for preventing podocyte damage remain insufficient.
Yu-Lin Kang, Moin Ahson Saleem, Kwok Wah Chan, Benjamin Yat-Ming Yung, Helen Ka-Wai Law   +4 more
doaj   +1 more source