Results 61 to 70 of about 899,728 (258)

Assessment of podocyte injury using two novel glomerular markers [PDF]

, 2016
The glomerular filtration barrier is an efficient filtration system, which ensures proper function of the kidney by avoiding proteinuria. At the same time, this barrier is also the most vulnerable component of the kidney.
Dubost, Valérie
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice

Journal of Diabetes Research, 2021
Objective. Microinflammation plays a crucial role in podocyte dysfunction in diabetic nephropathy, but its regulatory mechanism is still unclear. This study is aimed at discussing the mechanisms underlying the effect of miRNA-155 on podocyte injury to ...
Xiaolei Wang, Yanbin Gao, Wenming Yi, Yu Qiao, Hao Hu, Ying Wang, Yan Hu, Shuxin Wu, Hongfeng Sun, Taojing Zhang   +9 more
doaj   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Puromycin aminonucleoside‐induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3

FEBS Open Bio, 2020
Smad3 signaling and transgelin expression are often activated during puromycin aminonucleoside (PAN)‐induced podocyte injury. Here, we investigated whether the Smad3 inhibitor SIS3 can ameliorate damage to injured podocytes.
Lina Jiang, Hong Cui, Jie Ding, Aijun Yang, Yingchao Zhang   +4 more
doaj   +1 more source

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Podocyte RIPK3 Deletion Improves Diabetic Kidney Disease by Attenuating NF‐κB p65 Driven Inflammation

Advanced Science
Receptor‐interacting protein kinase 3 (RIPK3) is a key player in necroptosis and an emerging inflammation regulator, whose contribution to podocyte injury in diabetic kidney disease (DKD) remain unclear.
Lu'an Li, Jiaying Li, Ruizhao Li, Xingchen Zhao, Yuanhan Chen, Yating Cai, Yan Yang, Weiteng Wang, Siqi Zheng, Li Zhang, Xinling Liang   +10 more
doaj   +1 more source

Morin Alleviates Fructose-Driven Disturbance of Podocyte Mitochondrial Energy Metabolism by Inhibiting Adenosine 5′-Monophosphate Deaminase Activity to Improve Glomerular Injury

Pharmaceuticals
Background/Objectives: High fructose consumption is a significant risk factor for glomerular podocyte injury. This study aimed to identify the underlying mechanism of fructose-induced podocyte injury and explore the protective effect of the natural ...
Yingzhi Yang, Ziyan Wan, Luyi Huang, Ziang Zhou, Wanru Wang, Yu Xing, Shijie Li, Yufan Du, Jiufang Huang, Yanqing Wu, Mengyu Fan, Jiahuang Li, Lingdong Kong, Dongmei Zhang   +13 more
doaj   +1 more source

KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression

JCI Insight, 2023
Despite recent progress in the identification of mediators of podocyte injury, mechanisms underlying podocyte loss remain poorly understood, and cell-specific therapy is lacking.
Kristin Meliambro, Yanfeng Yang, Marina de Cos, Estefania Rodriguez Ballestas, Caroline Malkin, Jonathan Haydak, John R. Lee, Fadi Salem, Laura H. Mariani, Ronald E. Gordon, John M. Basgen, Huei Hsun Wen, Jia Fu, Evren U. Azeloglu, John Cijiang He, Jenny S. Wong, Kirk N. Campbell   +16 more
doaj   +1 more source

Early podocyte injury and premature glomerular aging - Supplemental Material

, 2023
Supplemental material for publication on early podocyte injury and premature glomerular aging.
Joseph C. Maggiore (17122728), Robert Allen Schweickart (17122729), Natalya Kaverina (17122758), Anthony Chang (17122772), Neil A. Hukriede (17122787), Yuting Zeng (17122725), Sierra R McKinzie (17122763), Carol J. Loretz (17122773), Beatriz Maria Veloso Pereira (17118214), Karina Thieme (17122784), Stuart J. Shankland (17122794), Diana G. Eng (6739319), Oliver Wessely (17122790), Jeffrey W. Pippin (6739329)   +13 more
core   +1 more source