Results 71 to 80 of about 29,045 (218)

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

Tmem30a protects against podocyte injury through suppression of pyroptosis

iScience
Summary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou, Sipei Chen, Lei Peng, Liming Huang, Huijian Zhang, Ping Zhang, Min Yu, Lin Xiong, Xiang Zhong, Wenjing Liu, Xianjun Zhu, Li Wang, Yi Li, Guisen Li   +13 more
doaj   +1 more source

Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy

JCI Insight, 2023
Albuminuria and podocyte injury are the key cellular events in the progression of diabetic nephropathy (DN). Acetyl-CoA synthetase 2 (ACSS2) is a nucleocytosolic enzyme responsible for the regulation of metabolic homeostasis in mammalian cells.
Jian Lu, Xue Qi Li, Pei Pei Chen, Jia Xiu Zhang, Liang Liu, Gui Hua Wang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Zhong Ruan, Kun Ling Ma   +11 more
doaj   +1 more source

C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation [PDF]

, 2019
Hypertrophy is a prominent feature of damaged podocytes in diabetic kidney disease (DKD). mTORC1 hyperactivation leads to podocyte hypertrophy, but the detailed mechanism of how mTORC1 activation occurs under pathological conditions is not completely ...
Ha, Tae-Sun, Jeong, Heeyoon, Kim, Eui, Koh, Ara, Lee, Jiyoun, Ryu, Sung Ho, Saleem, Moin A.   +6 more
core   +1 more source

Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage

Cellular Physiology and Biochemistry, 2018
Background/Aims: Podocyte damage is associated with proteinuria, glomerulosclerosis and decline of renal function. This study aimed to screen critical genes associated with podocyte injury in chronic kidney disease (CKD) by weighted gene correlation ...
Zhi Zuo, Jian-Xiao Shen, Yan Pan, Juan Pu, Yong-Gang Li, Xing-hua Shao, Wan-Peng  Wang   +6 more
doaj   +1 more source

Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. [PDF]

, 2014
Background: Podocytes are highly specialized cells integral to the normal functioning kidney, however, in diabetic nephropathy injury occurs leading to a compromised phenotype and podocyte dysfunction which critically produces podocyte loss with ...
Binder, Browne, Chuang, Dalla Vestra, Dessapt, Dorado, Drew, Fioretto, Gagliardini, Goldfarb, Hayashi, Herbach, Herman-Edelstein, Huang, Iwano, Khalil, Kim, Kim, Li, Maeda, Marchetti, Niculescu-Duvaz, Pavenstädt, Phanish, Reeves, Regan, Rocco, Saleem, Schiffer, Shishido, Siegel, Suzaki, Vardouli, Wahab, Winn, Woo, Wu, Zhou, Ziyadeh, Ziyadeh   +39 more
core   +2 more sources

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathy [PDF]

, 2014
Background: Activating mutations in the Transient Receptor Potential channel C6 (TRPC6) cause autosomal dominant focal segmental glomerular sclerosis (FSGS).
Berden, J.H.M. (Jo H.), Coenen, M.J. (Marieke), Hoefsloot, E.H. (Lies), Hofstra, J.M. (Julia), Knoers, N.V.A.M. (Nine), Nijenhuis, T. (Tom), Schijvenaars, M.M.V.A.P. (Mascha), Vlag, J. (Johan) van der, Wetzels, J.F.M. (Jack)   +8 more
core   +1 more source

Multimodal Assessment of Kidney Quality During 24‐h of Normothermic Machine Perfusion

Artificial Organs, EarlyView.
Normothermic machine perfusion (NMP) has emerged as a promising tool for assessing kidney quality prior to transplantation; however, reliable biomarkers remain to be established. In this study, thirteen porcine kidneys were perfused for 24 h using an autologous leukocyte‐filtered whole blood‐based perfusate applying urine recirculation.
Marlene Pühringer, Magdalena Kött, Andras T. Meszaros, Michael J. Blumer, Bettina Zelger, Stefan Redl, Martin Hermann, Thomas Resch, Simon Mathis, Gabriel Putzer, Judith Martini, Christina Bogensperger, Franka Messner, Julia Hofmann, Margot Fodor, Andrea Griesmacher, Annemarie Weissenbacher, Theresa Hautz, Gert Mayer, Hannes Neuwirt, Gerald Brandacher, Silvia Oberparleiter, Stefan Schneeberger   +22 more
wiley   +1 more source

Myeloid-Derived Suppressor Cells Induce Podocyte Injury Through Increasing Reactive Oxygen Species in Lupus Nephritis

Frontiers in Immunology, 2018
The expansion of myeloid-derived suppressor cells (MDSCs) has been documented in murine models and patients with lupus nephritis (LN), but the exact role of MDSCs in this process remains largely unknown.
Dongya Zhang, Jingjing Xu, Jing Ren, Liang Ding, Guoping Shi, Dan Li, Huan Dou, Huan Dou, Yayi Hou, Yayi Hou   +9 more
doaj   +1 more source