Results 81 to 90 of about 29,045 (218)

Non-canonical NFκB activation promotes chemokine expression in podocytes [PDF]

, 2016
TNF-like weak inducer of apoptosis (TWEAK) receptor Fn14 is expressed by podocytes and Fn14 deficiency protects from experimental proteinuric kidney disease. However, the downstream effectors of TWEAK/Fn14 in podocytes are poorly characterized.
Gonzalez-Lafuente, Laura, Ortiz, Alberto, Ruiz-Ortega, Marta, Sanchez-Niño, María D., Sanz, Ana Belén, Valiño-Rivas, Lara   +5 more
core   +2 more sources

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy

Advanced Science
Nuclear receptors (NRs) are important transcriptional factors that mediate autophagy, preventing podocyte injury and the progression of diabetic kidney disease (DKD).
Yaru Xie, Qian Yuan, Xinyi Cao, Yang Qiu, Jieyu Zeng, Yiling Cao, Yajuan Xie, Xianfang Meng, Kun Huang, Fan Yi, Chun Zhang   +10 more
doaj   +1 more source

Redox signaling, Nox5 and vascular remodeling in hypertension [PDF]

, 2015
Purpose of review: Extensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. However, molecular mechanisms underlying these processes remain unclear, but oxidative post-translational ...
De Lucca Camargo, Livia, Dulak-Lis, Maria, Harvey, Adam, Montezano, Augusto C., Touyz, Rhian M., Tsiropoulou, Sofia   +5 more
core   +1 more source

The insulin‐like growth factor system and the progression of renal complications of type 2 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Adrian Heald, Yasitha lllangasekera, Andreas Matheou, Ram Prakash Narayanan, Stephen White, Hellena Habte‐Asres, Abigail Lay, Liliana Shalamanova, William Ollier, Graham A. Hitman, Ritwika Mallik, Philip A. Kalra, Martin Whyte, J. Martin Gibson   +13 more
wiley   +1 more source

Urinary biomarkers associated with podocyte injury in lupus nephritis

Frontiers in Pharmacology
The most prevalent and devastating form of organ damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN). LN is characterized by glomerular injury, inflammation, cell proliferation, and necrosis, leading to podocyte injury and tubular ...
Zhiying Guo, Qianyu Guo, Xiaochen Li, Xinnan Gao, Liyun Zhang, Ke Xu   +5 more
doaj   +1 more source

Glomerular Function and Structure in Living Donors: Lessons from Single Nephron Studies [PDF]

, 2016
One third of the kidney transplants performed in the USA come from living kidney donors. The long-term outcome of healthy individuals who donate kidneys is mostly excellent, although recent studies have suggested that living donation is associated with a
Bryan D. Myers, Colin R. Lenihan, Jane C. Tan   +2 more
core   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Detection of podocyturia in patients with lupus nephritis [PDF]

, 2013
INTRODUCTION: The podocyturia has been detected in glomerular diseases, such as lupus nephritis (LN), in which proteinuria is an important manifestation, and its occurrence seems to be limited to the active phase of the disease.
Mansur, Juliana Busato, Mastroianni Kirsztajn, Gianna, Nishida, Sonia Kiyomi, Sabino, Amelia Rodrigues Pereira, Sass, Nelson, Teixeira, Vicente de Paulo Castro   +5 more
core   +3 more sources

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source