Results 81 to 90 of about 19,393 (195)
Cell Proliferation, EarlyView.This review outlines kidney organoid differentiation strategies, key developmental mechanisms, and engineering and multi‐omics approaches driving their progress toward regenerative medicine. ABSTRACT Chronic kidney disease (CKD) has emerged as a critical public health challenge worldwide, and organ donor shortages underscore the urgent need for ...
Bohong Guo +9 more
wiley +1 more source
Advanced ScienceNuclear receptors (NRs) are important transcriptional factors that mediate autophagy, preventing podocyte injury and the progression of diabetic kidney disease (DKD).
Yaru Xie +10 more
doaj +1 more source
Cell Proliferation, EarlyView.PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang +7 more
wiley +1 more source
Urinary biomarkers associated with podocyte injury in lupus nephritis
Frontiers in PharmacologyThe most prevalent and devastating form of organ damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN). LN is characterized by glomerular injury, inflammation, cell proliferation, and necrosis, leading to podocyte injury and tubular ...
Zhiying Guo +5 more
doaj +1 more source
The insulin‐like growth factor system and the progression of renal complications of type 2 diabetes
Diabetic Medicine, EarlyView.Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Adrian Heald +13 more
wiley +1 more source
The Complement System in Post‐Transplant Kidney Injury
Organ Medicine, EarlyView.
Mengsi Hu
wiley +1 more source
An update on the landscape of collagen bioactive fragments
The FEBS Journal, EarlyView.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
Mechanisms of Podocyte Injury in Kidney Allografts
Kidney360Long-term kidney allograft survival remains an important clinical challenge. While immune mediated injury, particularly antibody mediated rejection, is associated with long-term graft loss, nonimmune mechanisms also drive chronic allograft failure.
Gabriel C. Barsotti +3 more
openaire +2 more sources
Podocyte injury in diabetes mellitus
Diabetes mellitus, 2014 The mechanisms of podocyte injury and their correlation with metabolic and haemodynamic disorders in diabetes mellitus are considered in detail; the results of the last experimental and clinical studies on this problem are presented in this review. Authors shined the biomarkers, reflecting expressiveness of podocytopathy and structural and functional ...
Irina Nikolaevna Bobkova +2 more
openaire +2 more sources
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source