Results 1 to 10 of about 432,986 (215)

Collapsing Focal Segmental Glomerulosclerosis in Viral Infections

Frontiers in Immunology, 2022
Collapsing glomerulopathy represents a special variant of the proteinuric kidney disease focal segmental glomerulosclerosis (FSGS). Histologically, the collapsing form of FSGS (cFSGS) is characterized by segmental or global condensation and obliteration ...
Anne K. Muehlig, Anne K. Muehlig, Anne K. Muehlig, Sydney Gies, Tobias B. Huber, Fabian Braun   +5 more
doaj   +2 more sources

Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association

Frontiers in Medicine, 2020
Focal segmental glomerulosclerosis (FSGS) is a histological term that describes a pathologic renal entity affecting both adults and children, with a wide array of possible underlying etiologies.
Manuel Alfredo Podestà, Claudio Ponticelli   +1 more
doaj   +2 more sources

Mechanisms of Scarring in Focal Segmental Glomerulosclerosis

Kidney Diseases, 2021
Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern characterized by focal glomerular scarring, which often progresses to systemic and diffuse glomerulosclerosis.
Ke Sun, Qionghong Xie, Chuan-Ming Hao
doaj   +2 more sources

Controlling proteinuria in secondary focal segmental glomerulosclerosis with cyclosporine: A case report [PDF]

SAGE Open Medical Case Reports
Focal segmental glomerulosclerosis is a histopathological condition characterized by podocyte injury, which manifests as persistent proteinuria and progressive decline in renal function.
Sohrab Kharabaf, Matthew Nguyen, Dao Le, Ramy Hanna   +3 more
doaj   +2 more sources

Focal Segmental Glomerulosclerosis

Advances in kidney disease and health
Focal segmental glomerular sclerosis (FSGS) is a histological lesion characterized by sclerosis in sections (segmental) of some glomeruli (focal) in association with podocyte injury. Historically, FSGS has often been characterized as a disease, but it is
Rout P, Hashmi MF, Baradhi KM.
europepmc   +3 more sources

A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis

Kidney International Reports, 2017
Introduction Steroid-resistant focal segmental glomerulosclerosis (SR-FSGS) is a common glomerulopathy associated with nephrotic range proteinuria. Treatment goals are reduction in proteinuria, which can delay end-stage renal disease.
Lorenz Sellin, Loreto Gesualdo, Jai Radhakrishnan   +2 more
exaly   +2 more sources

Primary Focal Segmental Glomerulosclerosis among Patients with Glomerular Disease Undergoing Kidney Biopsy in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association, 2023
Introduction: Primary focal segmental glomerulosclerosis is a form of glomerular disease that needs immunosuppressive therapy, which, if untreated, can lead to end-stage renal disease.
Bikash Khatri, Anil Baral, Suresh Maharjan, Bijay Khatri   +3 more
doaj   +1 more source

Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis.

New England Journal of Medicine, 2023
BACKGROUND An unmet need exists for focal segmental glomerulosclerosis (FSGS) treatment. In an 8-week, phase 2 trial, sparsentan, a dual endothelin-angiotensin receptor antagonist, reduced proteinuria in patients with FSGS.
M. Rheault, C. Alpers, Jonathan Barratt, Stewart Bieler, P. Canetta, D. Chae, G. Coppock, U. Diva, L. Gesualdo, H. Heerspink, J. Inrig, G. Kirsztajn, Donald E. Kohan, Radko Komers, L. Kooienga, Kenneth V. Lieberman, Alex Mercer, I. Noronha, Vlado Perkovic, Jai Radhakrishnan, William Rote, B. Rovin, V. Tesař, H. Trimarchi, James A. Tumlin, M. G. Wong, H. Trachtman   +26 more
semanticscholar   +1 more source

Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease

Nature Communications, 2023
African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans.
Yask Gupta, David J Friedman, M. McNulty, Atlas Khan, B. Lane, Chen Wang, J. Ke, G. Jin, Benjamin Wooden, Andrea L Knob, Tze Y. Lim, G. B. Appel, Kinsie Huggins, Lili Liu, A. Mitrotti, M. Stangl, A. Bomback, R. Westland, M. Bodria, M. Marasà, N. Shang, David J. Cohen, R. Crew, W. Morello, P. Canetta, J. Radhakrishnan, J. Martino, Qingxue Liu, Wendy K. Chung, Angelica Espinoza, Yuan Luo, Wei-Qi Wei, Qi-Ping Feng, C. Weng, Yilu Fang, I. Kullo, M. Naderian, N. Limdi, M. Irvin, H. Tiwari, S. Mohan, Ma-Ya K. Rao, G. Dube, Ninad S. Chaudhary, O. Gutiérrez, Suzanne E. Judd, Mary Cushman, Leslie A. Lange, E. Lange, Daniel L. Bivona, M. Verbitsky, C. Winkler, Jeffrey B. Kopp, D. Santoriello, Ibrahim Batal, Sérgio Veloso Brant Pinheiro, E. A. Oliveira, A. C. E. Silva, I. Pisani, Enrico Fiaccadori, Fangming Lin, L. Gesualdo, Antonio Amoroso, G. Ghiggeri, V. D'Agati, R. Magistroni, E. Kenny, R. Loos, G. Montini, Friedhelm Hildebrandt, Dirk S. Paul, S. Petrovski, David B. Goldstein, M. Kretzler, R. Gbadegesin, A. Gharavi, K. Kiryluk, M. Sampson, Martin R. Pollak, S. Sanna-Cherchi   +79 more
semanticscholar   +1 more source

Btg2 Promotes Focal Segmental Glomerulosclerosis via Smad3‐Dependent Podocyte‐Mesenchymal Transition

Advancement of science, 2023
Podocyte injury plays a critical role in the progression of focal segmental glomerulosclerosis (FSGS). Here, it is reported that B‐cell translocation gene 2 (Btg2) promotes Adriamycin (ADR)‐induced FSGS via Smad3‐dependent podocyte‐mesenchymal transition.
Qiong-Dan Hu, Hong-Lian Wang, Jian Liu, T. He, R. Tan, Qiong Zhang, H. Su, Fahsai Kantawong, Hui-Yao Lan, Li Wang   +9 more
semanticscholar   +1 more source