Results 31 to 40 of about 432,986 (215)

Monogenic focal segmental glomerulosclerosis: A conceptual framework for identification and management of a heterogeneous disease

American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2022
Focal segmental glomerulosclerosis (FSGS) is not a disease, rather a pattern of histological injury occurring from a variety of causes. The exact pathogenesis has yet to be fully elucidated but is likely varied based on the type of injury and the primary
M. Sambharia, Prerna Rastogi, C. Thomas
semanticscholar   +1 more source

Urine Single-Cell RNA Sequencing in Focal Segmental Glomerulosclerosis Reveals Inflammatory Signatures

Kidney International Reports, 2021
Introduction Individuals with focal segmental glomerular sclerosis (FSGS) typically undergo kidney biopsy only once, which limits the ability to characterize kidney cell gene expression over time. Methods We used single-cell RNA sequencing (scRNA-seq) to
K. Latt, J. Heymann, Joseph Jessee, Avi Z. Rosenberg, C. Berthier, A. Arazi, S. Eddy, T. Yoshida, Yongmei Zhao, Vicky Chen, G. Nelson, M. Cam, Parimal Kumar, M. Mehta, Michael C. Kelly, M. Kretzler, P. Ray, M. Moxey-Mims, Gregory H. Gorman, B. Lechner, Renu Regunathan-Shenk, D. Raj, K. Suszták, C. Winkler, J. Kopp   +24 more
semanticscholar   +1 more source

Eluate derived by extracorporal antibody-based immunoadsorption elevates the cytosolic Ca2+ concentration in podocytes via B-2 kinin receptors [PDF]

, 2002
Background/Aim: Patients with idiopathic focal segmental glomerulosclerosis (FSGS) often develop a recurrence of the disease after kidney transplantation.
Pavenstadt, H., Rump, L. C., Fischer, Karl-Georg, Pavenstädt, Hermann, Schwertfeger, E., Henger, Anna, Fischer, K. G., Rump, Lars Christian, Fink, E., Huber, Tobias B., Schwertfeger, Eckhard, Henger, A., Huber, T. B., Fink, Edwin   +13 more
core   +1 more source

Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

Disease Models & Mechanisms, 2021
The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS flippases) and the β-subunit TMEM30A.
Wenjing Liu, Lei Peng, Wanli Tian, Yi Li, Ping Zhang, Kuanxiang Sun, Yeming Yang, Xiao Li, Guisen Li, Xianjun Zhu   +9 more
doaj   +1 more source

Identification of Genetic Causes of Focal Segmental Glomerulosclerosis Increases With Proper Patient Selection.

Mayo Clinic proceedings, 2021
OBJECTIVE To increase the likelihood of finding a causative genetic variant in patients with a focal segmental glomerulosclerosis (FSGS) lesion, clinical and histologic characteristics were analyzed.
Jing Miao, F. Vairo, Marie C. Hogan, S. Erickson, M. El Ters, A. Bentall, Aleksandra Kukla, E. Greene, L. Hernandez, S. Sethi, K. Lazaridis, P. Pichurin, E. Lisi, C. Prochnow, L. Zand, F. Fervenza   +15 more
semanticscholar   +1 more source

Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report

Journal of Medical Case Reports, 2019
Background Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy.
Arina Yamasaki, Daisuke Bito, Erina Eto, Keiichiro Matsumoto, Megumi Nakamura, Junji Miyazaki, Kenichi Matsumoto, Masanori Masuda, Daisuke Mori, Toru Yoshimura   +9 more
doaj   +1 more source

A case of minimal change nephrotic syndrome with immunoglobulin A nephropathy transitioned to focal segmental glomerulosclerosis [PDF]

, 2012
A 50-year-old woman with a 1-month history of lower extremity edema and a 5 kg weight increase was admitted to our hospital with suspected nephrotic syndrome in October 1999.
Miyazaki, Masanobu, Takashi Taguchi, Mineaki Kitamura, Misaki Hirose, Obata, Yoko, Uramatsu, Tadashi, Kitamura, Mineaki, Taguchi, Takashi, Nishino, Tomoya, Hirose, Misaki, Tayo Kawazu, Kohno, Shigeru, Shigeru Kohno, Tomoya Nishino, Masanobu Miyazaki, Tadashi Uramatsu, Yoko Obata, Kawazu, Tayo   +17 more
core   +1 more source

CUBN gene mutations may cause focal segmental glomerulosclerosis (FSGS) in children

BMC Nephrology, 2021
Background Imerslund-Gräsbeck Syndrome (IGS) is mainly caused by CUBN gene biallelic mutations. Proteinuria accompanies IGS specific symptoms in about half of the patients, isolated proteinuria is rarely reported. Here we present 3 patients with isolated
Jing Yang, Yongli Xu, Ling-Jie Deng, Luowen Zhou, Li-Ru Qiu, Yu Zhang, Jian-hua Zhou   +6 more
semanticscholar   +1 more source

A CD2AP Mutation Associated with Focal Segmental Glomerulosclerosis in Young Adulthood [PDF]

, 2016
Mutations in CD2-associated protein (CD2AP) have been identified in patients with focal segmental glomerulosclerosis (FSGS); however, reports of CD2AP mutations remain scarce.
Yoland Marie Anistan, Hohmann, M., Tsvetkov, D., Rudolph, B., Mannaa, M., Harteneck, C., Birgit Rudolph, Dmitry Tsvetkov, Maik Gollasch, Gollasch, M., Christian Harteneck, Anistan, Y.M., Marwan Mannaa, Michael Hohmann, Yol, Marie Anistan   +15 more
core   +1 more source

Immune-mediated entities of (primary) focal segmental glomerulosclerosis

Cell and Tissue Research, 2021
Focal segmental glomerulosclerosis (FSGS) represents a glomerular scar formation downstream of various different mechanisms leading to podocytopathy and podocyte loss.
Fabian Braun, I. Homeyer, N. Alachkar, T. Huber   +3 more
semanticscholar   +1 more source