Results 31 to 40 of about 27,995 (188)

Progression of albuminuria and podocyte injury in focal segmental glomerulosclerosis inhibited by enhanced glycosphingolipid GM3 via valproic acid

Scientific Reports, 2023
Focal segmental glomerulosclerosis, characterized by decreased numbers of podocytes in glomeruli, is a common cause of refractory nephrotic syndrome. Recently, we showed that enhanced glycosphingolipid GM3 expression after administration of valproic acid,
Nagako Kawashima, Shokichi Naito, Masaki Nagane, Tadashi Yamashita, Ken-ichi Nakayama   +4 more
doaj   +1 more source

The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506: Clinical significance and comparison with cyclosporine [PDF]

, 1993
The histopathological changes in 51 renal allograft biopsies from patients immunosuppressed with FK506 were compared with those seen in 30 needle biopsies obtained from patients on cyclosporine.
Demetris, AJ, Jordan, ML, Randhawa, PS, Shapiro, R, Starzl, TE   +4 more
core   +1 more source

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

Advanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler, Tim Lange, Sophia‐Marie Bach, Soeren S. Lienkamp, Nicole Endlich   +4 more
wiley   +1 more source

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. [PDF]

, 2015
Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin ...
Bild, Diane E, Divers, Jasmin, Freedman, Barry I, Hawfield, Amret T, Kaysen, George A, Kimmel, Paul L, Langefeld, Carl D, Pajewski, Nicholas M, Raj, Dominic S, Reboussin, David M, Ricardo, Ana C, Rocco, Michael V, Sedor, John R, Systolic Blood Pressure Intervention Trial (SPRINT), Wright, Jackson T   +14 more
core   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Non-ischemic cardiomyopathy with focal segmental glomerulosclerosis

Journal of Community Hospital Internal Medicine Perspectives, 2020
Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome, accounting for 40% of nephrotic syndrome in adults. FSGS has diverse clinical and morphological features and underlying pathogenesis.
Parminder Kaur, Balraj Singh, Prem Patel, Rahul Vasudev, Upamanyu Rampal, Fayez Shamoon   +5 more
doaj   +1 more source

Collapsing Focal Segmental Glomerulosclerosis in Viral Infections

Frontiers in Immunology, 2022
Collapsing glomerulopathy represents a special variant of the proteinuric kidney disease focal segmental glomerulosclerosis (FSGS). Histologically, the collapsing form of FSGS (cFSGS) is characterized by segmental or global condensation and obliteration ...
Anne K. Muehlig, Anne K. Muehlig, Anne K. Muehlig, Sydney Gies, Tobias B. Huber, Fabian Braun   +5 more
doaj   +1 more source

Impact of graft loss among kidney diseases with a high risk of post-transplant recurrence in the paediatric population [PDF]

, 2017
Background Some kidney diseases tend to recur in the renal allograft after transplantation. We studied the risk of graft loss among primary renal diseases known for their high risk of recurrence and compared it with that of patients with hypoplasia and ...
Belingheri, Mirco, Dudley, Jan, Dušek, Jiří, Grenda, Ryszard, Jager, Kitty J., Macher, Marie-Alice, Puretic, Zvonimir, Rubic, Jacek, Rudaitis, Sarunas, Rudin, Christoph, Schaefer, Franz, Szabó, Tamás, van Stralen, Karlijn J., Verrina, Enrico   +13 more
core   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Immune-complex glomerulonephritis with a membranoproliferative pattern in Frasier syndrome: a case report and review of the literature

BMC Nephrology, 2020
Background Mutations in the Wilms tumor 1 gene cause a spectrum of podocytopathy ranging from diffuse mesangial sclerosis to focal segmental glomerulosclerosis.
Daisuke Matsuoka, Shunsuke Noda, Motoko Kamiya, Yoshihiko Hidaka, Hisashi Shimojo, Yasushi Yamada, Tsutomu Miyamoto, Kandai Nozu, Kazumoto Iijima, Hiroyasu Tsukaguchi   +9 more
doaj   +1 more source