Results 21 to 30 of about 432,986 (215)

Post-transplant Recurrence of Focal Segmental Glomerulosclerosis: Consensus Statements.

Kidney International, 2023
Focal segmental glomerulosclerosis (FSGS) is one of the primary causes of nephrotic syndrome in both pediatric and adult patients, which can lead to end-stage kidney disease.
R. Raina, S. Nithyanantha Jothi, D. Haffner, Michael J. G. Somers, Guido Filler, Prabhav Vasistha, R. Chakraborty, R. Shapiro, P. Randhawa, R. Parekh, C. Licht, Timothy Bunchman, S. Sethi, Guneive Mangat, Joshua Zaritsky, Franz Schaefer, Bradley A. Warady, Sharon M. Bartosh, M. McCulloch, Khalid Alhasan, Agnieszka Swiatecka-Urban, W. Smoyer, A. Chandraker, Hui Kim Yap, V. Jha, A. Bagga, Jai Radhakrishnan   +26 more
semanticscholar   +1 more source

Current understanding of the molecular mechanisms of circulating permeability factor in focal segmental glomerulosclerosis

Frontiers in Immunology, 2023
The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully elucidated. However, a growing body of evidence emphasizes the pivotal role of
G. Salfi, F. Casiraghi, G. Remuzzi
semanticscholar   +1 more source

Morphometry of podocytes – a single center study of pediatric patients: is there any correlation with proteinuria level? [PDF]

Archives of the Balkan Medical Union, 2019
Introduction. The most common diagnosis after a kidney biopsy in pediatric population is minimal change disease. When the prognosis is not favorable in spite of the minimal change disease diagnosis, there is a clinical suspicion of focal segmental ...
Diana DEREWICZ, Roxana TARAS, Cosmin FLORESCU, Mihaela BALGRADEAN, Maria SAJIN   +4 more
doaj   +1 more source

Therapeutic Potential Targeting Podocyte Mitochondrial Dysfunction in Focal Segmental Glomerulosclerosis

Kidney Diseases, 2023
Background: Podocytes are essential components of the glomerular filtration barrier and essential for the proper filtration function of the glomerulus.
Yu-Ting Li, Jiaojiao Fan, Wenping Zhu, Yujia Niu, Meng-Qiu Wu, Ai-Hua Zhang   +5 more
semanticscholar   +1 more source

Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis

Kidney International, 2022
The diagnosis of nephrotic syndrome relies on clinical presentation and descriptive patterns of injury on kidney biopsies, but not specific to underlying pathobiology.
L. Mariani, S. Eddy, Fadhl M. Alakwaa, P. McCown, J. Harder, V. Nair, F. Eichinger, S. Martini, A. Ademola, V. Boima, H. Reich, Jamal El-Saghir, B. Godfrey, W. Ju, E. Tanner, V. Vega-Warner, Noel L. Wys, S. Adler, G. Appel, A. Athavale, M. Atkinson, S. Bagnasco, L. Barisoni, E. Brown, D. Cattran, Gaia M. Coppock, K. Dell, V. Derebail, F. Fervenza, A. Fornoni, C. Gadegbeku, Keisha Gibson, L. Greenbaum, S. Hingorani, M. Hladunewich, J. Hodgin, M. Hogan, L. Holzman, J. Jefferson, F. Kaskel, J. Kopp, R. Lafayette, K. Lemley, J. Lieske, Jen-Jar Lin, R. Menon, K. Meyers, P. Nachman, C. Nast, M. O'Shaughnessy, E. Otto, K. Reidy, K. Sambandam, J. Sedor, C. Sethna, P. Singer, T. Srivastava, Cheryl L. Tran, K. Tuttle, S. Vento, Chia-Shi Wang, A. Ojo, D. Adu, D. Gipson, H. Trachtman, M. Kretzler   +65 more
semanticscholar   +1 more source

Adult-Onset Genetic Focal Segmental Glomerulosclerosis: A Tale of Two Mutations

Revista Portuguesa de Nefrologia e Hipertensão, 2023
Focal segmental glomerulosclerosis (FSGS) is a kidney histologic lesion that may be caused by multiple aetiologies and pathophysiological mechanisms, with podocyte injury and depletion as the common denominator.
Luís Leite de Sousa, Gonçalo Pimenta, Rita Veríssimo, Rita Theias, Tiago Carvalho   +4 more
doaj   +1 more source

Comparing Kidney Health Outcomes in Children, Adolescents, and Adults With Focal Segmental Glomerulosclerosis

JAMA Network Open, 2022
Key Points Question Are kidney health outcomes different in children and adolescents compared with adults with focal segmental glomerulosclerosis (FSGS)?
D. Gipson, J. Troost, C. Spino, Samara Attalla, Josh M. Tarnoff, S. Massengill, R. Lafayette, V. Vega-Warner, S. Adler, P. Gipson, M. Elliott, F. Kaskel, Damian Fermin, M. Moxey-Mims, R. Fine, E. Brown, K. Reidy, K. Tuttle, Keisha Gibson, K. Lemley, L. Greenbaum, M. Atkinson, S. Hingorani, T. Srivastava, C. Sethna, K. Meyers, Cheryl L. Tran, K. Dell, Chia-Shi Wang, J. Yee, M. Sampson, R. Gbadegesin, J. J. Lin, T. Brady, M. Rheault, H. Trachtman   +35 more
semanticscholar   +1 more source

Interventions for focal segmental glomerulosclerosis in adults.

Cochrane Database of Systematic Reviews, 2022
BACKGROUND Focal segmental glomerulosclerosis (FSGS) can be separated into primary, genetic or secondary causes. Primary disease results in nephrotic syndrome while genetic and secondary forms may be associated with asymptomatic proteinuria or with ...
E. Hodson, A. Sinha, Tess E. Cooper
semanticscholar   +1 more source

Circulating nephrin autoantibodies and posttransplant recurrence of primary focal segmental glomerulosclerosis

American Journal of Transplantation, 2022
Posttransplant recurrence of primary focal segmental glomerulosclerosis (FSGS) is a major challenge in the field of kidney transplantation. Primary FSGS is thought to be caused by circulating factors (CFs) that injure podocytes, 1 but these factors ...
M. Hattori, Yoko Shirai, Shoichiro Kanda, K. Ishizuka, Naoto Kaneko, Taro Ando, M. Eguchi, Kenichiro Miura   +7 more
semanticscholar   +1 more source

Novel Treatment Paradigms: Focal Segmental Glomerulosclerosis

Kidney International Reports, 2022
Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury defined by the presence of sclerosis in some (segmental) of certain glomeruli (focal).
Marina de Cos, K. Meliambro, K. Campbell
semanticscholar   +1 more source