Results 21 to 30 of about 21,067 (213)

NPHS2variation in focal and segmental glomerulosclerosis [PDF]

BMC Nephrology, 2008
Abstract Background Focal and segmental glomerulosclerosis (FSGS) is the most common histologic pattern of renal injury seen in adults with idiopathic proteinuria. Homozygous or compound heterozygous mutations in the podocin gene NPHS2 are found in 10–30% of pediatric cases of steroid resistant nephrosis and/or FSGS.
Tonna, Stephen, Needham, Alexander, Polu, Krishna, Uscinski, Andrea, Appel, Gerald B., Falk, Ronald, Katz, Avi, Al-Waheeb, Salah, Kaplan, Bernard, Jerums, George, Savige, Judy, Harmon, Jennifer, Zhang, Kang, Curhan, Gary, Pollak, Martin   +14 more
openaire   +5 more sources

Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

Disease Models & Mechanisms, 2021
The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS flippases) and the β-subunit TMEM30A.
Wenjing Liu, Lei Peng, Wanli Tian, Yi Li, Ping Zhang, Kuanxiang Sun, Yeming Yang, Xiao Li, Guisen Li, Xianjun Zhu   +9 more
doaj   +1 more source

Eluate derived by extracorporal antibody-based immunoadsorption elevates the cytosolic Ca2+ concentration in podocytes via B-2 kinin receptors [PDF]

, 2002
Background/Aim: Patients with idiopathic focal segmental glomerulosclerosis (FSGS) often develop a recurrence of the disease after kidney transplantation.
Pavenstadt, H., Rump, L. C., Fischer, Karl-Georg, Pavenstädt, Hermann, Schwertfeger, E., Henger, Anna, Fischer, K. G., Rump, Lars Christian, Fink, E., Huber, Tobias B., Schwertfeger, Eckhard, Henger, A., Huber, T. B., Fink, Edwin   +13 more
core   +1 more source

Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report

Journal of Medical Case Reports, 2019
Background Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy.
Arina Yamasaki, Daisuke Bito, Erina Eto, Keiichiro Matsumoto, Megumi Nakamura, Junji Miyazaki, Kenichi Matsumoto, Masanori Masuda, Daisuke Mori, Toru Yoshimura   +9 more
doaj   +1 more source

Pathophysiology of focal segmental glomerulosclerosis [PDF]

Pediatric Nephrology, 2007
Focal segmental glomerulosclerosis (FSGS) is a major cause of idiopathic steroid-resistant nephrotic syndrome (SRNS) and end-stage kidney disease (ESKD). In recent years, animal models and studies of familial forms of nephrotic syndrome helped elucidate some mechanisms of podocyte injury and disease progression in FSGS. This article reviews some of the
Reidy, Kimberly, Kaskel, Frederick J.
openaire   +2 more sources

A case of minimal change nephrotic syndrome with immunoglobulin A nephropathy transitioned to focal segmental glomerulosclerosis [PDF]

, 2012
A 50-year-old woman with a 1-month history of lower extremity edema and a 5 kg weight increase was admitted to our hospital with suspected nephrotic syndrome in October 1999.
Miyazaki, Masanobu, Takashi Taguchi, Mineaki Kitamura, Misaki Hirose, Obata, Yoko, Uramatsu, Tadashi, Kitamura, Mineaki, Taguchi, Takashi, Nishino, Tomoya, Hirose, Misaki, Tayo Kawazu, Kohno, Shigeru, Shigeru Kohno, Tomoya Nishino, Masanobu Miyazaki, Tadashi Uramatsu, Yoko Obata, Kawazu, Tayo   +17 more
core   +1 more source

A CD2AP Mutation Associated with Focal Segmental Glomerulosclerosis in Young Adulthood [PDF]

, 2016
Mutations in CD2-associated protein (CD2AP) have been identified in patients with focal segmental glomerulosclerosis (FSGS); however, reports of CD2AP mutations remain scarce.
Yoland Marie Anistan, Hohmann, M., Tsvetkov, D., Rudolph, B., Mannaa, M., Harteneck, C., Birgit Rudolph, Dmitry Tsvetkov, Maik Gollasch, Gollasch, M., Christian Harteneck, Anistan, Y.M., Marwan Mannaa, Michael Hohmann, Yol, Marie Anistan   +15 more
core   +1 more source

A Case of Focal Segmental Glomerulosclerosis in Turner Syndrome [PDF]

Kosin Medical Journal, 2015
Turner syndrome is usually accompanied with various anomalies. Congenital urological and renal abnormalities are often associated with this syndrome. The occurrence of glomerulonephritis is uncommon.
A Rum Han, Young Ki Lee, Hyun Yon Jung, Jae Hyun Park, Jung-Woo Noh, Eun Suk Nam   +5 more
doaj   +1 more source

Cyclophosphamide in the treatment of focal segmental glomerulosclerosis [PDF]

Brazilian Journal of Medical and Biological Research, 2004
Prednisone is the initial treatment of primary focal segmental glomerulosclerosis. However, when immunosuppressive agents in combination with steroids are used in the treatment of prednisone-dependent and prednisone-resistant patients the remission rate ...
R. Martinelli, L.J. Pereira, O.M.M. Silva, A.S. Okumura, H. Rocha   +4 more
doaj   +1 more source

Unwinding focal segmental glomerulosclerosis [PDF]

F1000Research, 2017
Focal segmental glomerulosclerosis (FSGS) represents the most common primary glomerular disease responsible for the development of end-stage renal disease (ESRD) in the United States (US). The disease progresses from podocyte injury to chronic kidney disease (CKD), ultimately leading to total nephron degeneration.
Vasil Peev, Eunsil Hahm, Jochen Reiser
openaire   +2 more sources