Results 41 to 50 of about 21,067 (213)

Recurrent Focal Segmental Glomerulosclerosis after Renal Transplantation

, 1991
In a young adult male with chronic renal failure from focal segmental glomerulosclerosis, massive proteinuria appeared within two weeks after transplantation.
M. Minz, K.S. Chugh, V. Sakhuja, A.R. Datta, K. Joshi   +4 more
core   +1 more source

Progression of albuminuria and podocyte injury in focal segmental glomerulosclerosis inhibited by enhanced glycosphingolipid GM3 via valproic acid

Scientific Reports, 2023
Focal segmental glomerulosclerosis, characterized by decreased numbers of podocytes in glomeruli, is a common cause of refractory nephrotic syndrome. Recently, we showed that enhanced glycosphingolipid GM3 expression after administration of valproic acid,
Nagako Kawashima, Shokichi Naito, Masaki Nagane, Tadashi Yamashita, Ken-ichi Nakayama   +4 more
doaj   +1 more source

Focal Segmental Glomerulosclerosis with Sjogren Syndrome: A Case Report

Turkish Journal of Internal Medicine, 2021
Sjogren's syndrome (SjS) is a chronic, slow-progressing, autoimmune and lymphoproliferative disease. The main symptoms of the syndrome are xerostomia and keratoconjuctivitis sicca as a result of chronic inflammatory infiltration of the salivary and ...
Mehmet Sezen, Abdülmecit Yıldız, Kamil Dilek, Mustafa Güllülü, Mahmut Yavuz, Ayşegül Oruç, Mehmet Fethullah Aydın, Alparslan Ersoy   +7 more
doaj   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, Accepted Article.
Background Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. Immunoglobulin G (IgG) from LN patients displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

Spectrum of disease in familial focal and segmental glomerulosclerosis

, 1999
Spectrum of disease in familial focal and segmental glomerulosclerosisBackgroundFocal segmental glomerulosclerosis (FSGS) is the underlying pathologic entity in 5% of adults and 20% of children with end-stage renal disease (ESRD).
Winn, Michelle P., Quarles, L. Darryl, on behalf of the International Collaborative Group for the Study of Familial Focal and Segmental Glomerulosclerosis, on behalf of the International Collaborative Group for the Study of Familial Focal and Segmental, Howell, David N, Lynn, Kelvin, Conlon, Peter J., Conlon, Peter J, Winn, Michelle P, Bembe, Mary Lou, Speer, Marcy, Pericak-Vance, Margaret, Howell, David N., on behalf of the International Collaborative Group for the Study of Familial Focal and Segmental Glomerulosclerosis,   +12 more
core   +1 more source

Urinary symmetric dimethylarginine: A promising biomarker for acute kidney injury in dogs with pyometra

Veterinary Record, EarlyView.
Abstract Background Symmetric dimethylarginine (SDMA) is a biomarker of renal function derived from arginine methylation, unaffected by muscle mass or diet, and increases after only a 25% reduction in renal function, allowing earlier detection of renal dysfunction compared with serum creatinine.
Larissa Ayane do Nascimento Braz, Suellen Rodrigues Maia, Lara Vilela Soares, Natani Silva Reis, Leandro Zuccolotto Crivellenti, Andrigo Barboza de Nardi   +5 more
wiley   +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Collapsing Focal Segmental Glomerulosclerosis in Viral Infections

Frontiers in Immunology, 2022
Collapsing glomerulopathy represents a special variant of the proteinuric kidney disease focal segmental glomerulosclerosis (FSGS). Histologically, the collapsing form of FSGS (cFSGS) is characterized by segmental or global condensation and obliteration ...
Anne K. Muehlig, Anne K. Muehlig, Anne K. Muehlig, Sydney Gies, Tobias B. Huber, Fabian Braun   +5 more
doaj   +1 more source

Glomerular plasmalemma vesicle‐associated protein‐1 as an endothelial remodelling marker complementing C4d in chronic active antibody‐mediated rejection

Histopathology, EarlyView.
Glomerular plasmalemma vesicle‐associated protein‐1 (PV‐1/PLVAP) identifies dynamic endothelial remodelling in chronic active antibody‐mediated rejection (caABMR), complementing glomerular C4d, which reflects a static footprint of complement activation. Combined assessment of PV‐1 and C4d captures complementary dimensions of microvascular pathology and
Yuto Igarashi, Mayu Shimokawa, Kunio Kawanishi, Toshihito Hirai, Hiroshi Seino, Tomokazu Shimizu, Hideki Ishida, Toshio Takagi   +7 more
wiley   +1 more source

The elusive podocyte crossmatch for recurrent focal segmental glomerulosclerosis

, 2019
Focal segmental glomerulosclerosis is a glomerular disorder with a high rate of recurrence. Although kidney biopsies remain the gold standard to diagnose recurrent focal segmental glomerulosclerosis, non-invasive prognostic assays could facilitate ...
Burke, 3rd, George W, Fornoni, Alessia
core   +1 more source