The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus. [PDF]
Int J Mol Sci, 2023 Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease ...
Mason WJ, Vasilopoulou E.
europepmc +7 more sources
Proteolysis and inflammation of the kidney glomerulus. [PDF]
Cell Tissue Res, 2021 Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease.
Demir F +7 more
europepmc +8 more sources
The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus [PDF]
Nature CommunicationsThe kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong +9 more
doaj +3 more sources
Profiling and annotation of human kidney glomerulus proteome. [PDF]
Proteome Sci, 2013 BackgroundThe comprehensive analysis of human kidney glomerulus we previously performed using highly purified glomeruli, provided a dataset of 6,686 unique proteins representing 2,966 distinct genes.
Cui Z +10 more
europepmc +5 more sources
GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening. [PDF]
Commun Biol, 2021 The glomerulus is the filtration unit of the kidney. Injury to any component of this specialised structure leads to impaired filtration and eventually fibrosis and chronic kidney disease.
Tuffin J +6 more
europepmc +2 more sources
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. [PDF]
J Am Soc Nephrol, 2020 BACKGROUND The glomerulus is a specialized capillary bed that is involved in urine production and BP control. Glomerular injury is a major cause of CKD, which is epidemic and without therapeutic options. Single-cell transcriptomics has radically improved
Chung JJ +9 more
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Determinants of Vascular Permeability in the Kidney Glomerulus* [PDF]
Journal of Biological Chemistry, 2002 The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the urine because of alterations in the glomerular filtration unit of the kidney.
Y. Hamano +8 more
semanticscholar +4 more sources
Organogenesis of the kidney glomerulus [PDF]
Organogenesis, 2011 The glomerular basement membrane (GBM) is a crucial component of the kidney's filtration barrier that separates the vasculature from the urinary space. During glomerulogenesis, the GBM is formed from fusion of two distinct basement membranes, one synthesized by the glomerular epithelial cell (podocyte) and the other by the glomerular endothelial cell ...
J. Miner
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New Descriptor for Glomerulus Detection in Kidney Microscopy Image [PDF]
BMC Bioinformatics, 2015 Glomerulus detection is a key step in histopathological evaluation of microscopy images of kidneys. However, the task of automatic detection of glomeruli poses challenges due to the disparity in sizes and shapes of glomeruli in renal sections.
Hayliang Ngouv +6 more
core +6 more sources
Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus. [PDF]
Kidney International, 1999 The detailed mechanisms of glucocorticoid action in idiopathic nephrotic syndrome and progressive glomerulonephritides have not been clearly elucidated. The pharmacological actions of glucocorticoids are mediated by their binding to an intracellular protein, the glucocorticoid receptor (GR).
Kunimasa Yan +14 more
semanticscholar +3 more sources