Results 1 to 10 of about 1,184,321 (146)

The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus [PDF]

International Journal of Molecular Sciences, 2023
Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease ...
William John Mason, Elisávet Vasilopoulou   +1 more
exaly   +3 more sources

The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus [PDF]

Nature Communications
The kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong, Victoria Driscoll, Sandrine Ettou, Keith Keller, Amha Atakilit, Mary E. Taglienti, Saurabh Kumar, Astrid Weins, Valerie A. Schumacher, Jordan A. Kreidberg   +9 more
doaj   +3 more sources

GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening. [PDF]

Commun Biol, 2021
The glomerulus is the filtration unit of the kidney. Injury to any component of this specialised structure leads to impaired filtration and eventually fibrosis and chronic kidney disease.
Tuffin J, Chesor M, Kuzmuk V, Johnson T, Satchell SC, Welsh GI, Saleem MA.   +6 more
europepmc   +2 more sources

Proteolysis and inflammation of the kidney glomerulus. [PDF]

Cell Tissue Res, 2021
Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease.
Demir F, Troldborg A, Thiel S, Lassé M, Huesgen PF, Tomas NM, Wiech T, Rinschen MM.   +7 more
europepmc   +2 more sources

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. [PDF]

J Am Soc Nephrol, 2020
BACKGROUND The glomerulus is a specialized capillary bed that is involved in urine production and BP control. Glomerular injury is a major cause of CKD, which is epidemic and without therapeutic options. Single-cell transcriptomics has radically improved
Chung JJ, Goldstein L, Chen YJ, Lee J, Webster JD, Roose-Girma M, Paudyal SC, Modrusan Z, Dey A, Shaw AS.   +9 more
europepmc   +2 more sources

Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing. [PDF]

Kidney Int, 2018
Understanding of cellular transdifferentiation is limited by the technical inability to track multiple lineages in vivo. To overcome this we developed a new tool to simultaneously fate map two distinct cell types in the kidney, and genetically test ...
Eng DG, Kaverina NV, Schneider RRS, Freedman BS, Gross KW, Miner JH, Pippin JW, Shankland SJ.   +7 more
europepmc   +2 more sources

Profiling and annotation of human kidney glomerulus proteome. [PDF]

Proteome Sci, 2013
BackgroundThe comprehensive analysis of human kidney glomerulus we previously performed using highly purified glomeruli, provided a dataset of 6,686 unique proteins representing 2,966 distinct genes.
Cui Z, Yoshida Y, Xu B, Zhang Y, Nameta M, Magdeldin S, Makiguchi T, Ikoma T, Fujinaka H, Yaoita E, Yamamoto T.   +10 more
europepmc   +2 more sources

Ultrasmall polymeric nanocarriers for drug delivery to podocytes in kidney glomerulus

Journal of Controlled Release, 2017
Francesco Cellesi, Piergiorgio Messa
exaly   +2 more sources

Large-scale identification of genes implicated in kidney glomerulus development and function

EMBO Journal, 2006
Yusuke Baba, Jaaakko Patrakka, Petter Mostad   +2 more
exaly   +2 more sources

Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus

Nephrology Dialysis Transplantation, 2011
Toshihiko Fujimori, Masakiyo Sasahara, Yo-Ichi Nabeshima   +2 more
exaly   +2 more sources