Results 1 to 10 of about 36,605 (291)

The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus [PDF]

International Journal of Molecular Sciences, 2023
Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression.
William J Mason, Elisávet Vasilopoulou
exaly   +9 more sources

Proteolysis and inflammation of the kidney glomerulus. [PDF]

Cell Tissue Res, 2021
AbstractProteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis.
Demir F, Troldborg A, Thiel S, Lassé M, Huesgen PF, Tomas NM, Wiech T, Rinschen MM.   +7 more
europepmc   +8 more sources

Glomerulus Classification and Detection Based on Convolutional Neural Networks

Journal of Imaging, 2018
Glomerulus classification and detection in kidney tissue segments are key processes in nephropathology used for the correct diagnosis of the diseases. In this paper, we deal with the challenge of automating Glomerulus classification and detection from ...
Jaime Gallego, Anibal Pedraza, Samuel Lopez, Georg Steiner, Lucia Gonzalez, Arvydas Laurinavicius, Gloria Bueno   +6 more
doaj   +2 more sources

Determinants of Vascular Permeability in the Kidney Glomerulus [PDF]

Journal of Biological Chemistry, 2002
The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma proteins into the urine because of alterations in the glomerular filtration unit of the kidney. In this regard, the human mutations in nephrin, podocin, alpha-actinin-4, COL4A3, and COL4A5 genes
Hamano, Yuki, Grunkemeyer, James A., Sudhakar, Akulapalli, Zeisberg, Michael, Cosgrove, Dominic, Morello, Roy, Lee, Brendan, Sugimoto, Hikaru, Kalluri, Raghu   +8 more
openaire   +4 more sources

Endothelin and the Glomerulus in Chronic Kidney Disease [PDF]

Seminars in Nephrology, 2015
Endothelin-1 (ET-1) is a 21-amino acid peptide with mitogenic and powerful vasoconstricting properties. Under healthy conditions, ET-1 is expressed constitutively in all cells of the glomerulus and participates in homeostasis of glomerular structure and filtration function.
Matthias Barton, Andrey Sorokin
exaly   +4 more sources

The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus [PDF]

Nature Communications
The kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong, Victoria Driscoll, Sandrine Ettou, Keith Keller, Amha Atakilit, Mary E. Taglienti, Saurabh Kumar, Astrid Weins, Valerie A. Schumacher, Jordan A. Kreidberg   +9 more
doaj   +2 more sources

Somatostatin-like immunoreactivity in the glomerulus of rat kidney

Kidney International, 1983
It has been shown that somatostatin inhibits the antidiuretic action of vasopressin in toad urinary bladder in vitro and in dogs and rats in vivo. The presence of somatostatin-like immunoreactivity (SLI) in the urinary bladder and kidney of the toad has suggested the possibility that somatostatin may act as a local paracrine hormone modulating the ...
Kurokawa, Kiyoshi, Aponte, Gregory W., Fujibayashi, Shigeru, Yamada, Tadataka   +3 more
openaire   +3 more sources

Profiling and annotation of human kidney glomerulus proteome. [PDF]

Proteome Sci, 2013
Abstract Background The comprehensive analysis of human kidney glomerulus we previously performed using highly purified glomeruli, provided a dataset of 6,686 unique proteins representing 2,966 distinct genes. This dataset, however, contained considerable redundancy resulting from identification criteria under which ...
Cui Z, Yoshida Y, Xu B, Zhang Y, Nameta M, Magdeldin S, Makiguchi T, Ikoma T, Fujinaka H, Yaoita E, Yamamoto T.   +10 more
europepmc   +4 more sources

GlomSpheres as a 3D co-culture spheroid model of the kidney glomerulus for rapid drug-screening. [PDF]

Commun Biol, 2021
The glomerulus is the filtration unit of the kidney. Injury to any component of this specialised structure leads to impaired filtration and eventually fibrosis and chronic kidney disease.
Tuffin J, Chesor M, Kuzmuk V, Johnson T, Satchell SC, Welsh GI, Saleem MA.   +6 more
europepmc   +2 more sources

Transcriptional profiling of the kidney glomerulus

, 2010
The kidney glomerulus plays a crucial role in ultraltration of the blood through the glomerular capillary wall. Glomerulus injury may occur in many systemic and primary kidney diseases or as secondary eects to drugs and infections. It has been shown that many known glomerular specic/enriched genes play crucial roles in the maintenance of glomerular ...
Ying Sun (23237)
openaire   +2 more sources