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Biomimetic models of the glomerulus [PDF]
Nature Reviews Nephrology, 2022 The use of biomimetic models of the glomerulus has the potential to improve our understanding of the pathogenesis of kidney diseases and to enable progress in therapeutics. Current in vitro models comprise organ-on-a-chip, scaffold-based and organoid approaches.
Marta G. Valverde +7 more
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The Glomerulus According to the Mesangium [PDF]
Frontiers in Medicine, 2022 The glomerulus is the functional unit for filtration of blood and formation of primary urine. This intricate structure is composed of the endothelium with its glycocalyx facing the blood, the glomerular basement membrane and the podocytes facing the urinary space of Bowman's capsule. The mesangial cells are the central hub connecting and supporting all
Jenny Nyström
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Clinical Journal of the American Society of Nephrology, 2014 The glomerulus, the filtering unit of the kidney, is a unique bundle of capillaries lined by delicate fenestrated endothelia, a complex mesh of proteins that serve as the glomerular basement membrane and specialized visceral epithelial cells that form the slit diaphragms between interdigitating foot processes.
Martin R, Pollak +3 more
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MicroRNAs and the glomerulus [PDF]
Experimental Cell Research, 2012 MicroRNAs (miRNAs) are short non-coding RNAs regulating gene expression at the post-transcriptional level by blocking translation or promoting cleavage of their target mRNAs. Increasing evidence shows that miRNAs play central roles in gene transcription, signal transduction and pathogenesis of human diseases.
Mitsuo, Kato +2 more
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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2012 Kidney function declines with age in the majority of the population. Although very few older people progress to end stage, the consequences of doing so are burdensome for the patient and very expensive for the society. Although some of the observed decline is likely due to changes in the vasculature, much is associated with the development of age ...
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A short history of 'glomerulus' [PDF]
Clinical Kidney Journal, 2013 After enjoying Kettritz's and Luft's Nephroquiz [1], I enjoyed even more their reply [2] to my comment, which they ended by posing an interesting dilemma: should we use the terms ‘glomerulus/glomeruli’, masculine gender, or ‘glomerulum/glomerula’, neutral gender?
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Journal of the American Society of Nephrology, 2005 The structural integrity of the glomerular capillaries stems from the stereotyped arrangement of the three constituent cell types: Podocytes (also called visceral epithelial cells), endothelial cells, and mesangial cells.
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An Introduction to Stereology with Applications to the Glomerulus [PDF]
Glomerular Diseases, 2021 <b><i>Background:</i></b> Stereology is the science of inferring quantitative features of 3-dimensional structures from lower dimensional samples of those structures (probes). It is a statistical discipline and therefore may seem intimidating to many potential users.
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An Energy Budget for the Olfactory Glomerulus [PDF]
The Journal of Neuroscience, 2007 Energy demands are becoming recognized as an important constraint on neural signaling. The olfactory glomerulus provides a well defined system for analyzing this question. Odor stimulation elicits high-energy demands in olfactory glomeruli where olfactory axons converge onto dendrites of olfactory bulb neurons.
Janna C, Nawroth +4 more
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