Results 21 to 30 of about 39,758 (162)

Biomimetic models of the glomerulus

Nature Reviews Nephrology, 2022
The use of biomimetic models of the glomerulus has the potential to improve our understanding of the pathogenesis of kidney diseases and to enable progress in therapeutics. Current in vitro models comprise organ-on-a-chip, scaffold-based and organoid approaches.
Marta G. Valverde, Luis S. Mille, Kianti P. Figler, Ernesto Cervantes, Vanessa Y. Li, Joseph V. Bonventre, Rosalinde Masereeuw, Yu Shrike Zhang   +7 more
openaire   +4 more sources

Injection of hybrid 3D spheroids composed of podocytes, mesenchymal stem cells, and vascular endothelial cells into the renal cortex improves kidney function and replenishes glomerular podocytes

Bioengineering & Translational Medicine, 2021
Podocytes are highly differentiated epithelial cells that are crucial for maintaining the glomerular filtration barrier in the kidney. Podocyte injury followed by depletion is the major cause of pathological progression of kidney diseases.
Wen‐Yu Yang, Li‐Chi Chen, Ya‐Ting Jhuang, Yu‐Jie Lin, Pei‐Yu Hung, Yi‐Ching Ko, Meng‐Yu Tsai, Yun‐Wei Lee, Li‐Wen Hsu, Chih‐Kuang Yeh, Hsiang‐Hao Hsu, Chieh‐Cheng Huang   +11 more
doaj   +1 more source

The ShGlomAssay Combines High-Throughput Drug Screening With Downstream Analyses and Reveals the Protective Role of Vitamin D3 and Calcipotriol on Podocytes

Frontiers in Cell and Developmental Biology, 2022
Chronic kidney disease (CKD) is a major public health burden affecting more than 500 million people worldwide. Podocytopathies are the main cause for the majority of CKD cases due to pathogenic morphological as well as molecular biological alterations of
Marie-Christin Ristov, Tim Lange, Nadine Artelt, Neetika Nath, Andreas W. Kuss, Jochen Gehrig, Jochen Gehrig, Maja Lindenmeyer, Clemens D. Cohen, Sheraz Gul, Karlhans Endlich, Uwe Völker, Nicole Endlich   +12 more
doaj   +1 more source

A resource for the Drosophila antennal lobe provided by the connectome of glomerulus VA1v

eLife, 2018
Using FIB-SEM we report the entire synaptic connectome of glomerulus VA1v of the right antennal lobe in Drosophila melanogaster. Within the glomerulus we densely reconstructed all neurons, including hitherto elusive local interneurons.
Jane Anne Horne, Carlie Langille, Sari McLin, Meagan Wiederman, Zhiyuan Lu, C Shan Xu, Stephen M Plaza, Louis K Scheffer, Harald F Hess, Ian A Meinertzhagen   +9 more
doaj   +1 more source

Functional Reintegration of Sensory Neurons and Transitional Dendritic Reduction of Mitral/Tufted Cells during Injury-Induced Recovery of the Larval Xenopus Olfactory Circuit

Frontiers in Cellular Neuroscience, 2017
Understanding the mechanisms involved in maintaining lifelong neurogenesis has a clear biological and clinical interest. In the present study, we performed olfactory nerve transection on larval Xenopus to induce severe damage to the olfactory circuitry ...
Sara J. Hawkins, Sara J. Hawkins, Lukas Weiss, Lukas Weiss, Thomas Offner, Thomas Offner, Katarina Dittrich, Katarina Dittrich, Thomas Hassenklöver, Thomas Hassenklöver, Thomas Hassenklöver, Ivan Manzini, Ivan Manzini, Ivan Manzini   +13 more
doaj   +1 more source

Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities

Frontiers in Physiology, 2021
Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang, Bohan Chen, James Shaffner, Lance D. Dworkin, Rujun Gong   +4 more
doaj   +1 more source

Bioinformatics Analysis Reveals Crosstalk Among Platelets, Immune Cells, and the Glomerulus That May Play an Important Role in the Development of Diabetic Nephropathy

Frontiers in Medicine, 2021
Diabetic nephropathy (DN) is the main cause of end stage renal disease (ESRD). Glomerulus damage is one of the primary pathological changes in DN. To reveal the gene expression alteration in the glomerulus involved in DN development, we screened the Gene
Xinyue Yao, Hong Shen, Fukai Cao, Hailan He, Boyu Li, Haojun Zhang, Xinduo Zhang, Zhiguo Li   +7 more
doaj   +1 more source

Kidney sphaerosporosis with extrasporogonic stages in the blood in Baryancistrus sp. (Loricaridae) from Amazonian Brazil

Parasite, 2001
Examined fish of the genus Baryancistrus (Loricaridae) from Rio Xingu in central amazonian Brazil were found infected with extrasporogonic stages of Sphaerospora sp.
Paperna I., Di Cave D.
doaj   +1 more source

Molecular and Cellular Mechanisms Underlying the Initiation and Progression of Alport Glomerular Pathology

Frontiers in Medicine, 2022
Alport syndrome results from a myriad of variants in the COL4A3, COL4A4, or COL4A5 genes that encode type IV (basement membrane) collagens. Unlike type IV collagen α1(IV)2α2(IV)1 heterotrimers, which are ubiquitous in basement membranes, α3/α4/α5 have a ...
Dominic Cosgrove, Jacob Madison
doaj   +1 more source

Fine particulate matter (PM2.5) induces microRNA-192–5p causing glomerular damage

Ecotoxicology and Environmental Safety
An association between air pollution and the incidence of membranous glomerulonephritis (MGN) has been shown in epidemiological studies. However, the causality of this relationship and data on potential pathomechanisms are still missing.
Melina Yarbakht, George Sarau, Yanyi Xu, Xinyi Fang, Zeynab Mirzaei, René Krüger, Yalan Xiao, Arslan Usman, Christoph Daniel, Mario Schiffer, Silke Christiansen, Janina Müller-Deile   +11 more
doaj   +1 more source