Results 21 to 30 of about 48,150 (297)
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2012 Kidney function declines with age in the majority of the population. Although very few older people progress to end stage, the consequences of doing so are burdensome for the patient and very expensive for the society. Although some of the observed decline is likely due to changes in the vasculature, much is associated with the development of age ...
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Single Cell Transcriptome Helps Better Understanding Crosstalk in Diabetic Kidney Disease
Frontiers in Medicine, 2021 Years of research revealed that crosstalk extensively existed among kidney cells, cell factors and metabolites and played an important role in the development of diabetic kidney disease (DKD). In the last few years, single-cell RNA sequencing (scRNA-seq)
Chunyang Du +5 more
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The Journal of Pathology: Clinical Research, 2021 Electron microscopy (EM) following immunofluorescence (IF) imaging is a vital tool for the diagnosis of human glomerular diseases, but the implementation of EM is limited to specialised institutions and it is not available in many countries.
Edwin Garcia +10 more
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A human glomerular SAGE transcriptome database [PDF]
, 2009 Background: To facilitate in the identification of gene products important in regulating renal glomerular structure and function, we have produced an annotated transcriptome database for normal human glomeruli using the SAGE approach.
Kulak, Stephen C. +14 more
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Bioengineering & Translational Medicine, 2021 Podocytes are highly differentiated epithelial cells that are crucial for maintaining the glomerular filtration barrier in the kidney. Podocyte injury followed by depletion is the major cause of pathological progression of kidney diseases.
Wen‐Yu Yang +11 more
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Frontiers in Cell and Developmental Biology, 2022 Chronic kidney disease (CKD) is a major public health burden affecting more than 500 million people worldwide. Podocytopathies are the main cause for the majority of CKD cases due to pathogenic morphological as well as molecular biological alterations of
Marie-Christin Ristov +12 more
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A resource for the Drosophila antennal lobe provided by the connectome of glomerulus VA1v
eLife, 2018 Using FIB-SEM we report the entire synaptic connectome of glomerulus VA1v of the right antennal lobe in Drosophila melanogaster. Within the glomerulus we densely reconstructed all neurons, including hitherto elusive local interneurons.
Jane Anne Horne +9 more
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Frontiers in Cellular Neuroscience, 2017 Understanding the mechanisms involved in maintaining lifelong neurogenesis has a clear biological and clinical interest. In the present study, we performed olfactory nerve transection on larval Xenopus to induce severe damage to the olfactory circuitry ...
Sara J. Hawkins +13 more
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Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities
Frontiers in Physiology, 2021 Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang +4 more
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Frontiers in Medicine, 2021 Diabetic nephropathy (DN) is the main cause of end stage renal disease (ESRD). Glomerulus damage is one of the primary pathological changes in DN. To reveal the gene expression alteration in the glomerulus involved in DN development, we screened the Gene
Xinyue Yao +7 more
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