Results 1 to 10 of about 31,106 (252)
Controversies in Podocyte Loss: Death or Detachment?
Frontiers in Cell and Developmental Biology, 2021 Glomerular podocytes are characterized by terminally differentiated epithelial cells with limited proliferating ability; thus, podocyte loss could not be fully compensated by podocyte regeneration.
John He, Anqun Chen, Yin Lijun
exaly +3 more sources
Frontiers in Pharmacology, 2021 Background: Podocyte injury has a direct causal relationship with proteinuria and glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression. Podocyte injury plays a critically decisive role in the development of proteinuric
Yongli Zhan, Huimin Mao, Mao Huimin
exaly +3 more sources
Redox Biology, 2018 Early podocyte loss is characteristic of chronic kidney diseases (CKD) in obesity and diabetes. Since treatments for hyperglycemia and hypertension do not prevent podocyte loss, there must be additional factors causing podocyte depletion.
Susan Burke +2 more
exaly +3 more sources
F1000Research, 2016 Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule. When it comes to glomerular filtration, podocytes play an active role in preventing plasma proteins from entering the urinary ultrafiltrate by providing a barrier comprising filtration slits between foot ...
Jochen Reiser, Mehmet M. Altintas
openaire +3 more sources
Podocyte Injury Damages Other Podocytes [PDF]
Journal of the American Society of Nephrology, 2011 Loss of podocytes promotes glomerulosclerosis, but whether this results from a continued primary insult or a secondary mechanism triggered by the initial loss of podocytes is unknown. We generated chimeric mice in which only a subpopulation of podocytes expressed hCD25, which is the receptor for the immunotoxin LMB2.
Taiji, Matsusaka +6 more
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Cells, 2021 Vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2 are the main targets of antiangiogenic therapies, and proteinuria is one of the common adverse events associated with the inhibition of the VEGFA/VEGFR2 pathway.
Xiaoying Gu, Su Zhang, Ti Zhang
doaj +1 more source
Genes and Diseases, 2022 Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen +9 more
doaj +1 more source
Scientific Reports, 2021 Podocyte abnormalities are common mechanism driving the progression of glomerular diseases, which account for most chronic kidney diseases (CKDs). However, the role of podocyte in the mechanism of high-risk long-term CKD caused by prematurity has not ...
Fangrui Ding +4 more
doaj +1 more source
Frontiers in Physiology, 2021 Podocyte loss plays a pivotal role in the pathogenesis of glomerular disease. However, the mechanisms underlying podocyte damage and loss remain poorly understood.
Kathryn E. Haley +11 more
doaj +1 more source
PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment
Renal Failure, 2023 Podocytes play a critical role in maintaining normal glomerular filtration, and podocyte loss from the glomerular basement membrane (GBM) initiates and worsens chronic kidney disease (CKD).
Xiaoxiao Huang +10 more
doaj +1 more source