Results 21 to 30 of about 33,221 (207)

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Genes and Diseases, 2022
Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen, Chunhua Weng, Yucheng Wang, Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen   +9 more
doaj   +1 more source

Increasing urinary podocyte mRNA excretion and progressive podocyte loss in kidney contribute to the high risk of long-term renal disease caused by preterm birth

Scientific Reports, 2021
Podocyte abnormalities are common mechanism driving the progression of glomerular diseases, which account for most chronic kidney diseases (CKDs). However, the role of podocyte in the mechanism of high-risk long-term CKD caused by prematurity has not ...
Fangrui Ding, Qi Gao, Xiuying Tian, Jiali Mo, Jun Zheng   +4 more
doaj   +1 more source

YAP Translocation Precedes Cytoskeletal Rearrangement in Podocyte Stress Response: A Podometric Investigation of Diabetic Nephropathy

Frontiers in Physiology, 2021
Podocyte loss plays a pivotal role in the pathogenesis of glomerular disease. However, the mechanisms underlying podocyte damage and loss remain poorly understood.
Kathryn E. Haley, Kathryn E. Haley, Mustafa Elshani, Mustafa Elshani, In Hwa Um, Cameron Bell, Cameron Bell, Peter D. Caie, David J. Harrison, David J. Harrison, Paul A. Reynolds, Paul A. Reynolds   +11 more
doaj   +1 more source

Flying podocytes [PDF]

Kidney International, 2009
Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocytes, including the nephrin-based slit
Simons, Matias, Huber, Tobias B.
openaire   +3 more sources

Endothelin and the podocyte [PDF]

Clinical Kidney Journal, 2012
In the past decade, research has advanced our understanding how endothelin contributes to proteinuria and glomerulosclerosis. Data from pre-clinical and clinical studies now provide evidence that proteinuric diseases such as focal segmental glomerulosclerosis and diabetic nephropathy as well as hypertension nephropathy are sensitive to treatment with ...
Barton M, Tharaux PL
openaire   +3 more sources

PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment

Renal Failure, 2023
Podocytes play a critical role in maintaining normal glomerular filtration, and podocyte loss from the glomerular basement membrane (GBM) initiates and worsens chronic kidney disease (CKD).
Xiaoxiao Huang, Zhaowei Chen, Zilv Luo, Yiqun Hao, Jun Feng, Zijing Zhu, Xueyan Yang, Zongwei Zhang, Jijia Hu, Wei Liang, Guohua Ding   +10 more
doaj   +1 more source

SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation

Kidney Diseases, 2021
Background: Podocyte injury contributes to progressive glomerulosclerosis. Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone.
Mingzhu Jiang, Min Zhao, Mi Bai, Juan Lei, Yanggang Yuan, Songming Huang, Yue Zhang, Guixia Ding, Zhanjun Jia, Aihua Zhang   +9 more
doaj   +1 more source

Knowledge Domain and Emerging Trends in Podocyte Injury Research From 1994 to 2021: A Bibliometric and Visualized Analysis

Frontiers in Pharmacology, 2021
Background: Podocyte injury has a direct causal relationship with proteinuria and glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression. Podocyte injury plays a critically decisive role in the development of proteinuric
Tongtong Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Yongli Zhan   +5 more
doaj   +1 more source

Podocyte injury damages podocytes in chimeric organoids. [PDF]

PLoS One
Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenitor cells of two mouse lines: one expressing a receptor for a ...
Udagawa T, Araoka T, Osafune K, Matsusaka T.   +3 more
europepmc   +2 more sources

Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury [PDF]

, 2020
Podocyte injury is an independent risk factor for the progression of renal diseases. Semaphorin3A (SEMA3A), expressed in podocytes and tubular cells in the mammalian adult kidneys, has been reported to regulate diverse biological functions and be ...
Sang, Yizhen, Inoue-Torii, Akiko, Kenji Tsuji, Jun Wada, Akiko Inoue-Torii, Kazuhiko Fukushima, Fukushima, Kazuhiko, Shinji Kitamura, Tsuji, Kenji, Kitamura, Shinji, Wada, Jun, Yizhen Sang   +11 more
core   +2 more sources