Results 11 to 20 of about 33,221 (207)
Current Opinion in Nephrology and Hypertension, 2009 PURPOSE OF REVIEW: The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important ...
Mathieson, PW
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Urinary ANGPTL3: a novel noninvasive biomarker for podocyte injury in pediatric glomerular diseases [PDF]
Journal of Translational MedicineBackground Podocyte injury constitutes the pathological basis of various glomerular diseases; however noninvasive tools for assessing podocyte injury remain limited.
Hengmin Wang +11 more
doaj +2 more sources
The podocyte power-plant disaster and its contribution to glomerulopathy [PDF]
Frontiers in Endocrinology, 2014 Proper podocyte function within the glomerulus demands a high and continuous energy supply that is mainly derived from the respiratory chain of the inner mitochondrial membrane.
Janina eMüller-Deile, Mario eSchiffer
doaj +2 more sources
Redox Biology, 2018 Early podocyte loss is characteristic of chronic kidney diseases (CKD) in obesity and diabetes. Since treatments for hyperglycemia and hypertension do not prevent podocyte loss, there must be additional factors causing podocyte depletion.
Susan Burke +2 more
exaly +3 more sources
A Review of Podocyte Biology [PDF]
American Journal of Nephrology, 2018 <b><i>Background:</i></b> Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria.
Puneet Garg
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Tmem30a protects against podocyte injury through suppression of pyroptosis
iScienceSummary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou +13 more
doaj +2 more sources
Controversies in Podocyte Loss: Death or Detachment?
Frontiers in Cell and Developmental Biology, 2021 Glomerular podocytes are characterized by terminally differentiated epithelial cells with limited proliferating ability; thus, podocyte loss could not be fully compensated by podocyte regeneration.
Lijun Yin +5 more
doaj +1 more source
F1000Research, 2016 Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule. When it comes to glomerular filtration, podocytes play an active role in preventing plasma proteins from entering the urinary ultrafiltrate by providing a barrier comprising filtration slits between foot ...
Jochen Reiser, Mehmet M. Altintas
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Podocyte Injury Damages Other Podocytes [PDF]
Journal of the American Society of Nephrology, 2011 Loss of podocytes promotes glomerulosclerosis, but whether this results from a continued primary insult or a secondary mechanism triggered by the initial loss of podocytes is unknown. We generated chimeric mice in which only a subpopulation of podocytes expressed hCD25, which is the receptor for the immunotoxin LMB2.
Taiji, Matsusaka +6 more
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Cells, 2021 Vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2 are the main targets of antiangiogenic therapies, and proteinuria is one of the common adverse events associated with the inhibition of the VEGFA/VEGFR2 pathway.
Xiaoying Gu, Su Zhang, Ti Zhang
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