Results 11 to 20 of about 31,106 (252)
Podocyte Depletion in Thin GBM and Alport Syndrome. [PDF]
PLoS ONE, 2016 The proximate genetic cause of both Thin GBM and Alport Syndrome (AS) is abnormal α3, 4 and 5 collagen IV chains resulting in abnormal glomerular basement membrane (GBM) structure/function. We previously reported that podocyte detachment rate measured in
Larysa Wickman +5 more
doaj +2 more sources
Urinary Podocyte Excretion Predicts Urinary Protein Selectivity and Renal Prognosis [PDF]
International Journal of Nephrology, 2022 Background. Urinary podocyte excretion is related to a reduction in glomerular podocyte numbers, glomerulosclerosis, and urinary protein selectivity.
Makoto Abe +4 more
doaj +2 more sources
The podocyte power-plant disaster and its contribution to glomerulopathy [PDF]
Frontiers in Endocrinology, 2014 Proper podocyte function within the glomerulus demands a high and continuous energy supply that is mainly derived from the respiratory chain of the inner mitochondrial membrane.
Janina eMüller-Deile, Mario eSchiffer
doaj +2 more sources
Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. [PDF]
PLoS ONE, 2014 Podocyte injury is the first step in the progression of glomerulosclerosis. Previous studies have demonstrated the beneficial effect of bone morphogenetic protein 7 (Bmp7) in podocyte injury and the existence of native Bmp signaling in podocytes.
Sachiko Yamada +19 more
doaj +2 more sources
Tmem30a protects against podocyte injury through suppression of pyroptosis [PDF]
iScienceSummary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou +13 more
doaj +2 more sources
A Review of Podocyte Biology [PDF]
American Journal of Nephrology, 2018 <b><i>Background:</i></b> Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving the function of podocyte ...
Puneet Garg
openaire +4 more sources
[Podocyte dysfunction and proteinuria]. [PDF]
Nederlands tijdschrift voor geneeskunde, 2004 Podocytes play a central role in the pathogenesis of several glomerular diseases. In recent years, this has been revealed by molecular analysis of a number of rare hereditary renal diseases. Podocytes contain three domains: the domain bound to the glomerular basement membrane (GBM), the domain of the slit diaphragms and the apical domain.
Vogtländer, N.P.J. +3 more
openaire +4 more sources
Kidney Diseases, 2021 Background: Podocyte injury contributes to progressive glomerulosclerosis. Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone.
Mingzhu Jiang +9 more
doaj +1 more source
Kidney International, 2009 Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocytes, including the nephrin-based slit
Simons, Matias, Huber, Tobias B.
openaire +3 more sources
Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury [PDF]
, 2020 Podocyte injury is an independent risk factor for the progression of renal diseases. Semaphorin3A (SEMA3A), expressed in podocytes and tubular cells in the mammalian adult kidneys, has been reported to regulate diverse biological functions and be ...
Sang, Yizhen +11 more
core +3 more sources