Results 31 to 40 of about 33,221 (207)
Podocyte Biology and the Emerging Understanding of Podocyte Diseases [PDF]
American Journal of Nephrology, 2003 The understanding of the unique molecular apparatus of the podocyte has increased dramatically in recent years. This new knowledge has improved the diagnosis and classification of the diseases that have been termed podocytopathies. Podocyte injury frequently leads to reorganization of the slit diaphragm and reorganization of the foot process structure.
Laura, Barisoni, Peter, Mundel
openaire +2 more sources
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core +1 more source
A Podocyte view on RhoGTPases and actin cytoskeleton regulation [PDF]
, 2020 Proteinuria is a hallmark symptom of chronic kidney disease, that if left to persist constitutes a risk for progression of disease. Symptomatic treatment aiming at decreasing proteinuria is therefore standard practice.
Bergwall, Lovisa
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Podocyte Mitosis - A Catastrophe [PDF]
Current Molecular Medicine, 2012 Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm.
LASAGNI, LAURA +4 more
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Podocyte Lipotoxicity in CKD [PDF]
Kidney360, 2021 CKD represents the ninth most common cause of death in the United States but, despite this large health burden, treatment options for affected patients remain limited. To remedy this, several relevant pathways have been identified that may lead to novel therapeutic options.
Jin-Ju, Kim +2 more
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Fatty acids and their metabolism critically regulate podocyte survival [PDF]
, 2014 Diabetic nephropathy (DN) is the most common cause of end-stage renal disease in industrialized countries, and most affected patients have type 2 diabetes.
Kampe, Kapil Dev
core +1 more source
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Liliana Schäfer +42 more
core +1 more source
The podocyte and the proteoglycan [PDF]
American Journal of Physiology-Renal Physiology, 2016 proteoglycans (PGs) consist of a core protein and linear sugar side chains [glycosaminoglycans (GAGs)] attached to the core protein, e.g., agrin, perlecan, glypican, and syndecan. GAGs comprise repeating duplex sugar units made of an aminosugar (e.g., N -acetylglucosamine or N -acetylgalactosamine)
openaire +2 more sources
Erk5 Mediates TGFβ1-induced Loss of Phenotype and Function in Human Podocytes [PDF]
, 2014 Diabetic nephropathy is one of the most common causes of renal impairment. Podocytes are specialised cells integral to normal kidney physiology, however in diabetes injury occurs leading to compromised function which is a critical factor in the ...
Irbaz I. Badshah +8 more
core +1 more source
A human glomerular SAGE transcriptome database [PDF]
, 2009 Background: To facilitate in the identification of gene products important in regulating renal glomerular structure and function, we have produced an annotated transcriptome database for normal human glomeruli using the SAGE approach.
Kulak, Stephen C. +14 more
core +2 more sources