Results 31 to 40 of about 23,040 (117)

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, Volume 13, Issue 31, 4 June 2026.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1137-1150, June 2026.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Vitamin D receptor signaling in inflammatory senescence–associated skin aging: Mechanisms and therapeutic potentials

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Vitamin D receptor (VDR) signaling is implicated in inflammatory senescence‐associated skin aging, a growing health concern in aging populations where cellular senescence and chronic inflammation converge to create complex pathophysiological conditions.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

NAT10‐mediated N4‐acetylcytidine modification drives RNA splicing of PML to alleviate adipose‐derived stem cell senescence and promote diabetic wound healing

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
N‐acetyltransferase 10 (NAT10) catalyses N4‐acetylcytidine (ac4C) modification of PML pre‐mRNA, shifting splicing from the senescence‐promoting PML‐FL to the senescence‐inhibiting PML‐S isoform via SRSF1. This rejuvenates adipose‐derived stem cells (ADSCs) by reducing senescence markers and senescence‐associated secretory phenotype (SASP), thereby ...
Wuhan Wei, Chanyuan Jiang, Dong Zhu, Xuefeng Han, Xuan Ma, Xinyu Jia, Jiaqi Ling, Rui Zhang, Facheng Li, Ningbei Yin   +9 more
wiley   +1 more source

PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Downregulation of PPP2R3C in lupus CD4+ T cells unleashes JNK/c‑Jun and PLCγ1 signalling, driving calcium influx and inflammatory cytokine production. Reconstitution of PPP2R3C expression curbs T cell activation, lowers autoantibody levels and alleviates lupus nephritis, highlighting PPP2R3C as a promising therapeutic candidate. Abstract Background CD4+
Xuan Fang, Yi Qin, Jinhui Tao, Zhou Zhou, Minglong Cai, Hong Zhang, Xiangpei Li, Xiaomei Li, Zhu Chen   +8 more
wiley   +1 more source

Biomarkers for Early Detection of Diabetic Kidney Disease in Pediatric and Adolescent Populations: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Diabetic nephropathy is among the most critical long‐term complications linked to diabetes, substantially influencing both morbidity and mortality. Although it was once largely associated with adults, diabetic kidney disease (DKD) has now become a leading source of kidney complications among children worldwide.
Iran Malekzadeh, Narges Falsafi, Mohammad Nazemi, Hanie Taherkhani, Mahboube Bahroudi, Asim Abbas, Mastaneh Moghtaderi   +6 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Tocilizumab and Dexamethasone Reduce TNF‐α and IL‐33 and Oxidative Stress in Kidney Tissue in Oleic Acid‐Induced ARDS Model

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
Oleic acid causes ARDS‐associated AKI. Tocilizumab and dexamethasone reduces ARDS‐induced kidney injury. The width of the filtration slits increases in kidney injury. Tocilizumab and dexamethasone suppress TNF‐a and IL‐33. ABSTRACT The most common extrapulmonary organ injury in cases of acute respiratory distress syndrome (ARDS) is acute kidney injury (
Huseyin Serkan Erol, Beste Demirci, Mohammad Alhilal, Funda Terzi, Nazli Kelercioglu   +4 more
wiley   +1 more source

RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Peripheral nerve injury‐induced muscle atrophy shares core pathophysiological features with systemic wasting disorders including cachexia and sarcopenia, yet early molecular triggers remain undefined. This study investigates the pathogenic role of receptor‐interacting protein kinase 3 (RIPK3) in denervation atrophy.
Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun   +6 more
wiley   +1 more source