Results 31 to 40 of about 31,106 (252)
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Liliana Schäfer +42 more
core +2 more sources
Circulating risk variant APOL1 causes podocyte loss. [PDF]
, 2022 (A) Podocyte density is lower in glomeruli from Alb/APOL1-G1 mice. Podocount, a computational tool for whole-slide podocyte estimation, was used to derive podometrics from digitized kidney slides.
Clark M. Henderson (21861) +19 more
core +1 more source
The podocyte and the proteoglycan [PDF]
American Journal of Physiology-Renal Physiology, 2016 proteoglycans (PGs) consist of a core protein and linear sugar side chains [glycosaminoglycans (GAGs)] attached to the core protein, e.g., agrin, perlecan, glypican, and syndecan. GAGs comprise repeating duplex sugar units made of an aminosugar (e.g., N -acetylglucosamine or N -acetylgalactosamine)
openaire +2 more sources
Podocyte-specific FcRn KO resulted in mesangial expansion as mice aged. [PDF]
, 2019 A, 6 month old podocyte-specific FcRn KO mice had a decrease in mean glomerular area (**, p B, By 12 months of age, mean glomerular area was similar in podocyte-specific FcRn KO and control mice but the podocyte-specific KO manifested a further increase ...
Linda Lewis (6407513) +6 more
core +1 more source
Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease. [PDF]
PLoS ONE, 2015 Podocyte injury plays central roles in proteinuria and kidney dysfunction, therefore, identifying specific biomarker to evaluate earlier podocyte injury is highly desirable.
Jian-Si Li +10 more
doaj +1 more source
Podocyte-specific FcRn KO resulted in a significant increase in intraglomerular IgG accumulation, but no change in albumin accumulation. [PDF]
, 2019 A, Intraglomerular IgG: At 3 months of age, there was no significant difference in IgG accumulation between podocyte specific FcRn KO (fl/fl; cre/+) and control mice (fl/fll;+/+). (n = 3 mice per group).
Linda Lewis (6407513) +6 more
core +1 more source
Podocyte Mitosis - A Catastrophe [PDF]
Current Molecular Medicine, 2012 Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm.
LASAGNI, LAURA +4 more
openaire +3 more sources
Podocyte-specific FcRn KO resulted in increased glomerular expression of α-smooth muscle actin. [PDF]
, 2019 Intraglomerular expression of α-smooth muscle actin (α-SMA) was significantly increased in 6 month podocyte-specific FcRn KO (fl/fl;Cre/+) mice compared to controls (fl/fl;+/) (*, p < 0.01, n = 6 control and 6 KO mice).
Linda Lewis (6407513) +6 more
core +1 more source
Erk5 Mediates TGFβ1-induced Loss of Phenotype and Function in Human Podocytes [PDF]
, 2014 Diabetic nephropathy is one of the most common causes of renal impairment. Podocytes are specialised cells integral to normal kidney physiology, however in diabetes injury occurs leading to compromised function which is a critical factor in the ...
Irbaz I. Badshah +8 more
core +1 more source
BMC Nephrology, 2006 Background A reduction in the number of podocytes and podocyte density has been documented in the kidneys of patients with diabetes mellitus. Additional studies have shown that podocyte injury and loss occurs in both diabetic animals and humans. However,
Sullivan Kelli A +4 more
doaj +1 more source