Results 41 to 50 of about 31,106 (252)
Identification of novel podocyte stress-response mechanisms in vitro [PDF]
, 2019 Although podocyte injury has been correlated with glomerular disease progression, the mechanisms underlying podocyte response to stress in vivo remain poorly understood.
Haley, Kathryn Elizabeth
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Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. [PDF]
PLoS ONE, 2014 Glomerular diseases are commonly characterized by podocyte injury including apoptosis, actin cytoskeleton rearrangement and detachment. However, the strategies for preventing podocyte damage remain insufficient.
Yu-Lin Kang +4 more
doaj +1 more source
Journal of Clinical Investigation, 2011 The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental ...
openaire +2 more sources
A human glomerular SAGE transcriptome database [PDF]
, 2009 Background: To facilitate in the identification of gene products important in regulating renal glomerular structure and function, we have produced an annotated transcriptome database for normal human glomeruli using the SAGE approach.
Kulak, Stephen C. +14 more
core +1 more source
Frontiers in Pharmacology, 2022 Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as “podocyte disease.” There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations.
Lirong Lin +5 more
doaj +1 more source
Kidney360, 2023 As the population in many industrial countries is aging, the risk, incidence, and prevalence of CKD increases. In the kidney, advancing age results in a progressive decrease in nephron number and an increase in glomerulosclerosis. In this review, we focus on the effect of aging on glomerular podocytes, the post-mitotic epithelial cells critical for the
Stuart J. Shankland +4 more
openaire +2 more sources
Podocyte Biology for the Bedside [PDF]
American Journal of Kidney Diseases, 2011 The explosion of podocyte biology during the last decade has radically altered our views on the pathophysiologic process of proteinuria, glomerular disease, and progressive kidney disease. In this review, we highlight some of these landmark findings, but focus on recent advances in the field and implications for translating this biology into therapy ...
J Ashley, Jefferson +2 more
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CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]
, 2009 Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Amann, Kerstin Ute +11 more
core +1 more source
The Role of Palladin in Podocytes [PDF]
Journal of the American Society of Nephrology, 2018 Background Podocyte loss and effacement of interdigitating podocyte foot processes are the major cause of a leaky filtration barrier and ESRD. Because the complex three-dimensional morphology of podocytes depends on the actin cytoskeleton, we studied the role in podocytes of the actin bundling protein palladin, which is ...
Artelt, Nadine +13 more
openaire +4 more sources
Proteinuria increases in proportion to podocyte number per glomerular tuft and podocyte density decrease. [PDF]
, 2016 Panel A: Urine PCR shown on a linear scale in relation to podocyte density demonstrating that as podocyte density decreases below approximately 100 per 106 um3 the level of proteinuria exponentially increases.
Jeffrey B. Hodgin (617121) +5 more
core +1 more source