Results 41 to 50 of about 33,221 (207)
Kidney360, 2023 As the population in many industrial countries is aging, the risk, incidence, and prevalence of CKD increases. In the kidney, advancing age results in a progressive decrease in nephron number and an increase in glomerulosclerosis. In this review, we focus on the effect of aging on glomerular podocytes, the post-mitotic epithelial cells critical for the
Stuart J. Shankland +4 more
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Journal of Clinical Investigation, 2011 The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental ...
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The Role of Palladin in Podocytes [PDF]
Journal of the American Society of Nephrology, 2018 Background Podocyte loss and effacement of interdigitating podocyte foot processes are the major cause of a leaky filtration barrier and ESRD. Because the complex three-dimensional morphology of podocytes depends on the actin cytoskeleton, we studied the role in podocytes of the actin bundling protein palladin, which is ...
Artelt, Nadine +13 more
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, 2020 Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubular sclerosis complex 2 (Tsc2) knockout mouse model ...
Hideki Kato +25 more
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CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]
, 2009 Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Amann, Kerstin Ute +11 more
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Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset [PDF]
, 2010 Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function.
Clemens D Cohen +37 more
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Enzymatic disease of the podocyte [PDF]
Pediatric Nephrology, 2010 Proteinuria is an early sign of kidney disease and has gained increasing attention over the past decade because of its close association with cardio-vascular and renal morbidity and mortality. Podocytes have emerged as the cell type that is critical in maintaining proper functioning of the kidney filter.
Kistler AD +5 more
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Podocyte-specific FcRn KO resulted in mesangial expansion as mice aged.
, 2019 A, 6 month old podocyte-specific FcRn KO mice had a decrease in mean glomerular area (**, p B, By 12 months of age, mean glomerular area was similar in podocyte-specific FcRn KO and control mice but the podocyte-specific KO manifested a further increase ...
Linda Lewis (6407513) +6 more
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Circulating risk variant APOL1 causes podocyte loss.
, 2022 (A) Podocyte density is lower in glomeruli from Alb/APOL1-G1 mice. Podocount, a computational tool for whole-slide podocyte estimation, was used to derive podometrics from digitized kidney slides.
Clark M. Henderson (21861) +19 more
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, 2019 A, Intraglomerular IgG: At 3 months of age, there was no significant difference in IgG accumulation between podocyte specific FcRn KO (fl/fl; cre/+) and control mice (fl/fll;+/+). (n = 3 mice per group).
Linda Lewis (6407513) +6 more
core +1 more source