Results 51 to 60 of about 31,106 (252)

Loss of Nup155 promotes high fructose-driven podocyte senescence by inhibiting INO80 mRNA nuclear export

Journal of Advanced Research
Introduction: Podocyte senescence causes podocyte loss and glomerulopathy. Excessive fructose intake is a risk factor for podocyte injury. However, whether high fructose promotes podocyte senescence remains unknown.
Li Chen, Tangdi Xu, Zixuan Wang, Chengzhi Wang, Lei Fang, Lingdong Kong   +5 more
doaj   +1 more source

Role of the podocyte in proteinuria [PDF]

Pediatric Nephrology, 2011
In recent years, the podocyte, with its elaborate cytoarchitecture and slit diaphragm, has been the focus of extensive research, yet its precise role in the glomerular filtration barrier is still debated. There are puzzling observations indicating that a comprehensive mechanistic model for glomerular filtration is still necessary.
Menzel, Sylvia, Moeller, Marcus J.
openaire   +2 more sources

Clinical groupings showing podocyte depletion in ASC. [PDF]

, 2016
Clinical parameters are shown to the left side and podometric parameters to the right side of the Table. Since age impacts podometric parameters the control group (n = 17 biopsies from deceased kidney donors aged 4–17 years) is appropriate for the ASC ...
Jeffrey B. Hodgin (617121), Larysa Wickman (3169548), Su Q. Wang (3169545), Farsad Afshinnia (3169557), David Kershaw (3169551), Roger C. Wiggins (3169554)   +5 more
core   +1 more source

The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease

Kidney Diseases, 2021
Background: Podocytes, functionally specialized and terminally differentiated glomerular visceral epithelial cells, are critical for maintaining the structure and function of the glomerular filtration barrier.
Yu Sun, Sijia Cui, Yunfeng Hou, Fan Yi
doaj   +1 more source

Enzymatic disease of the podocyte [PDF]

Pediatric Nephrology, 2010
Proteinuria is an early sign of kidney disease and has gained increasing attention over the past decade because of its close association with cardio-vascular and renal morbidity and mortality. Podocytes have emerged as the cell type that is critical in maintaining proper functioning of the kidney filter.
Kistler AD, Peev V, Forst AL, El Hindi S, Altintas MM, Reiser J   +5 more
openaire   +3 more sources

Foxc2 is essential for podocyte function [PDF]

, 2019
Foxc2 is one of the earliest podocyte markers during glomerular development. To circumvent embryonic lethal effects of global deletion of Foxc2, and to specifically investigate the role of Foxc2 in podocytes, we generated mice with a podocyte-specific ...
Heglind, Mikael,, Nilsson, Daniel,, Enerbäck, Sven,, Arani, Zahra,   +3 more
core   +1 more source

MiR193a Modulation and Podocyte Phenotype [PDF]

, 2020
Apolipoprotein L1 (APOL1)-miR193a axis has been reported to play a role in the maintenance of podocyte homeostasis. In the present study, we analyzed transcription factors relevant to miR193a in human podocytes and their effects on podocytes&rsquo ...
Alok Jha, Himanshu Vashistha, Ashwani Malhotra, Kamesh Ayasolla, Karl Skorecki, Vashistha, H., Ayasolla, K., Malhotra, A., Shourav Saha, Jha, A., Saha, S., Skorecki, K., Singhal, P. C., Pravin C. Singhal   +13 more
core   +2 more sources

The Evolving Importance of Insulin Signaling in Podocyte Health and Disease

Frontiers in Endocrinology, 2018
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide, occuring in approximately one-third of diabetic patients.
Abigail C. Lay, Richard J. M. Coward
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk [PDF]

, 2022
Vascular endothelial growth factor A (VEGFA) secretion from podocytes is crucial for maintaining endothelial integrity within the glomerular filtration barrier.
Martin Helmstädter, Kretz, Oliver, Camila Hernando-Erhard, Bernd Kammerer, Tobias B. Huber, Lagies, Simon, Kosuke Yamahara, Tillmann Bork, Christoph Schell, Yamahara, Kosuke, Kammerer, Bernd, Huber, Tobias B., Hernando-Erhard, Camila, Liang, Wei, Helmstädter, Martin, Simon Lagies, Wei Liang, Oliver Kretz, Bork, Tillmann, Schell, Christoph   +19 more
core   +1 more source