Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. [PDF]
PLoS ONE, 2014 Glomerular diseases are commonly characterized by podocyte injury including apoptosis, actin cytoskeleton rearrangement and detachment. However, the strategies for preventing podocyte damage remain insufficient.
Yu-Lin Kang +4 more
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The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease
Kidney Diseases, 2021 Background: Podocytes, functionally specialized and terminally differentiated glomerular visceral epithelial cells, are critical for maintaining the structure and function of the glomerular filtration barrier.
Yu Sun, Sijia Cui, Yunfeng Hou, Fan Yi
doaj +1 more source
MiR193a Modulation and Podocyte Phenotype [PDF]
, 2020 Apolipoprotein L1 (APOL1)-miR193a axis has been reported to play a role in the maintenance of podocyte homeostasis. In the present study, we analyzed transcription factors relevant to miR193a in human podocytes and their effects on podocytes&rsquo ...
Alok Jha +13 more
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Podocyte-specific FcRn KO resulted in increased glomerular expression of α-smooth muscle actin.
, 2019 Intraglomerular expression of α-smooth muscle actin (α-SMA) was significantly increased in 6 month podocyte-specific FcRn KO (fl/fl;Cre/+) mice compared to controls (fl/fl;+/) (*, p < 0.01, n = 6 control and 6 KO mice).
Linda Lewis (6407513) +6 more
core +1 more source
The Evolving Importance of Insulin Signaling in Podocyte Health and Disease
Frontiers in Endocrinology, 2018 Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide, occuring in approximately one-third of diabetic patients.
Abigail C. Lay, Richard J. M. Coward
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Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]
PLoS ONE, 2012 BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu +17 more
doaj +1 more source
Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo
Biomedicine & Pharmacotherapy, 2019 Triptolide (TP) has an anti-proteinuric effect and is used for the treatment of podocytopathies. TP has also been shown to act directly on immortalized podocytes in culture to protect them from injury. In the present study, we examined the effect of TP on healthy podocytes both in vitro and in vivo to better understand the action of TP on podocytes. We
Mengjie, Sun +9 more
openaire +2 more sources
Mosaicism of podocyte involvement is related to podocyte injury in females with Fabry disease [PDF]
, 2014 Background: Fabry disease. an X-linked deficiency of α-galactosidase A coded by the GLA gene, leads to intracellular globotriaosylceramide (GL-3) accumulation. Although less common than in males, chronic kidney disease, occurs in ~15% of females.
Sokolovskiy, Alexey +17 more
core +2 more sources
Advanced ScienceReceptor‐interacting protein kinase 3 (RIPK3) is a key player in necroptosis and an emerging inflammation regulator, whose contribution to podocyte injury in diabetic kidney disease (DKD) remain unclear.
Lu'an Li +10 more
doaj +1 more source
Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury
Frontiers in Pharmacology, 2022 Podocyte injury and proteinuria are the most common features of glomerular disease, which is the leading cause of end-stage renal failure. Hyperactivated Wnt/β-catenin signaling is closely associated with podocyte injury, but the underlying mechanisms ...
Chunhong Wang +8 more
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