Results 71 to 80 of about 33,221 (207)

A new outlook towards kidney injuries [PDF]

, 2012
Acute and chronic progression of injury to the kidney leads to the failure of the renal system and has become an increasingly important cause of morbidity and mortality.
Mahesh Satwekar, Abhijeet Satwekar
core   +1 more source

Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease.

PLoS ONE, 2011
Injury to the glomerular podocyte is a key mechanism in human glomerular disease and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury is caused by the intracellular accumulation of globotriaosylceramide.
Thaneas Prabakaran, Rikke Nielsen, Jakob V Larsen, Søren S Sørensen, Ulla Feldt-Rasmussen, Moin A Saleem, Claus M Petersen, Pierre J Verroust, Erik I Christensen   +8 more
doaj   +1 more source

Proteinuria increases in proportion to podocyte number per glomerular tuft and podocyte density decrease.

, 2016
Panel A: Urine PCR shown on a linear scale in relation to podocyte density demonstrating that as podocyte density decreases below approximately 100 per 106 um3 the level of proteinuria exponentially increases.
Jeffrey B. Hodgin (617121), Larysa Wickman (3169548), Su Q. Wang (3169545), Farsad Afshinnia (3169557), David Kershaw (3169551), Roger C. Wiggins (3169554)   +5 more
core   +1 more source

Effects of Self-Made Prescription Compound Rhodiola on the Ultrastructure of Podocytes in Rats with Type 2 Diabetic Nephropathy

Emergency Medicine International, 2022
Background. We attempt to discuss the function of self-made prescription compound Rhodiola rosea on the kidneys of rats with type 2 diabetic nephropathy (DN), through studying the effects of self-made rescription compound Rhodiola rosea on the ...
Shaojing Yuan, Jie Liu, Zhenhua Sun, Lihua Meng, Jiying Zhu, Min Wang, Jie Su   +6 more
doaj   +1 more source

Podocyte Differentiation and Glomerulogenesis [PDF]

Journal of the American Society of Nephrology, 2003
This review will concentrate on the assembly of the glomerulus and the differentiation of the podocyte during that process. The differentiation of the vascular component of the glomerulus will not be emphasized, as it has been the subject of several recent reviews ([1][1]–[4][2]), except ...
openaire   +2 more sources

IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model

BMC Nephrology, 2018
Background The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium ...
Han Xu, Na Guan, Ya-Li Ren, Qi-Jiao Wei, Ying-Hong Tao, Guo-Sheng Yang, Xiao-Ya Liu, Ding-Fang Bu, Ying Zhang, Sai-Nan Zhu   +9 more
doaj   +1 more source

MicroRNAs in Podocyte Injury in Diabetic Nephropathy

Frontiers in Genetics, 2020
Diabetic nephropathy is one of the major complications of diabetes mellitus and is the leading cause of end-stage renal disease worldwide. Podocyte injury contributes to the development of diabetic nephropathy.
Hiroki Ishii, Shohei Kaneko, Katsunori Yanai, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita   +7 more
doaj   +1 more source

Clinical groupings showing podocyte depletion in ASC.

, 2016
Clinical parameters are shown to the left side and podometric parameters to the right side of the Table. Since age impacts podometric parameters the control group (n = 17 biopsies from deceased kidney donors aged 4–17 years) is appropriate for the ASC ...
Jeffrey B. Hodgin (617121), Larysa Wickman (3169548), Su Q. Wang (3169545), Farsad Afshinnia (3169557), David Kershaw (3169551), Roger C. Wiggins (3169554)   +5 more
core   +1 more source

BECLIN1 Is Essential for Podocyte Secretory Pathways Mediating VEGF Secretion and Podocyte-Endothelial Crosstalk

, 2022
Vascular endothelial growth factor A (VEGFA) secretion from podocytes is crucial for maintaining endothelial integrity within the glomerular filtration barrier.
Martin Helmstädter, Kretz, Oliver, Camila Hernando-Erhard, Bernd Kammerer, Tobias B. Huber, Lagies, Simon, Kosuke Yamahara, Tillmann Bork, Christoph Schell, Yamahara, Kosuke, Kammerer, Bernd, Huber, Tobias B., Hernando-Erhard, Camila, Liang, Wei, Helmstädter, Martin, Simon Lagies, Wei Liang, Oliver Kretz, Bork, Tillmann, Schell, Christoph   +19 more
core   +1 more source

Foxc2 is essential for podocyte function

, 2019
Foxc2 is one of the earliest podocyte markers during glomerular development. To circumvent embryonic lethal effects of global deletion of Foxc2, and to specifically investigate the role of Foxc2 in podocytes, we generated mice with a podocyte-specific ...
Heglind, Mikael,, Nilsson, Daniel,, Enerbäck, Sven,, Arani, Zahra,   +3 more
core   +1 more source