Results 71 to 80 of about 31,106 (252)
Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury
Frontiers in Pharmacology, 2022 Podocyte is also called glomerular epithelial cell, which has been considered as the final gatekeeper of glomerular filtration barrier (GFB). As a major contributor to proteinuria, podocyte injury underlies a variety of glomerular diseases and becomes ...
Tianwen Yao +6 more
doaj +1 more source
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
Reduction of Proteinuria through Podocyte Alkalinization [PDF]
, 2014 Podocytes are highly differentiated cells and critical elements for the filtration barrier of the kidney. Loss of their foot process (FP) architecture (FP effacement) results in urinary protein loss.
Reiser, Jochen +19 more
core +1 more source
Effect of N-acetyl-seryl-aspartyl-lysyl-proline on high glucose-induced podocyte injury
Linchuang shenzangbing zazhi, 2018 Objective To investigate the effect of N-acetyl-seryl-aspartyl-lysyl-proline(AcSDKP) on podocyte injury induced by high glucose and its possible mechanisms.Methods The conditionally immortalized mouse podocytes were treated by high glucose with or ...
ZHA Dong-qing, GAO Ping, WU Xiao-yan
doaj
BMC Nephrology, 2018 Background The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)/mitochondrial calcium ...
Han Xu +9 more
doaj +1 more source
The function of endocytosis in podocytes [PDF]
Current Opinion in Nephrology & Hypertension, 2013 In this review, we discuss the role of endocytosis, a fundamental process internalizing molecules from the plasma membrane, and its critical importance in podocyte biology.Endocytic clathrin and nonclathrin-coated pits have been visualized in podocytes using electron microscopy, but the functional biological relevance has not been well defined.
Keita, Soda, Shuta, Ishibe
openaire +2 more sources
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Comparison of two methods for measuring podocyte density. [PDF]
, 2016 Panel A. Log podocyte density plotted versus Glepp1 area (%). The two methods correlate with R2 = 0.70. Panel B. Podocyte density x glomerular volume gives the podocyte number per tuft. This value also correlates well with Glepp1 area (R2 = 0.63).
Jeffrey B. Hodgin (617121) +5 more
core +1 more source
GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction
Interdisciplinary Medicine, EarlyView.Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao +10 more
wiley +1 more source
Podocyte evaluation at 3 months after uninephrectomy. [PDF]
, 2013 (A) Immunofluorescence study of glomerular synaptopodin and WT1 in each group. (B) Average glomerular podocyte number (evaluated using the number of WT1-positive staining nuclei) in each group. No differences were noted among the groups.
Ching Fang Wu (499087) +11 more
core +1 more source