Results 81 to 90 of about 33,221 (207)
Podocyte GTPases regulate kidney filter dynamics [PDF]
, 2012 Our concept of the kidney filtration barrier is changing from one of a static sieve into one of a highly dynamic structure regulated through the motility of podocyte foot processes.
Kistler, Andreas D. +2 more
core +1 more source
Advanced ScienceNuclear receptors (NRs) are important transcriptional factors that mediate autophagy, preventing podocyte injury and the progression of diabetic kidney disease (DKD).
Yaru Xie +10 more
doaj +1 more source
Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition
iScienceSummary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes is ...
Jennifer A. Hurcombe +12 more
doaj +1 more source
Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond
CellsPodocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico +2 more
doaj +1 more source
Podocyte Injury in Lupus Nephritis
, 2019 Systemic lupus erythematosus (SLE) is characterized by a broad spectrum of renal lesions. In lupus glomerulonephritis, histological classifications are based on immune-complex (IC) deposits and hypercellularity lesions (mesangial and/or endocapillary) in
Vincent Audard +15 more
core +1 more source
Research advances on the role of ubiquitin proteasome in podocyte injury of diabetic kidney disease
Linchuang shenzangbing zazhiDiabetic kidney disease (DKD) is a disease of abnormal renal structure and function due to long-term hyperglycemia. Podocyte injury is a major cause of renal inflammation, glomerular filtration barrier injury and renal fibrosis.
Jin Wang, Wen-ling Dai, Ji-hua Liu
doaj +1 more source
Comparison of two methods for measuring podocyte density.
, 2016 Panel A. Log podocyte density plotted versus Glepp1 area (%). The two methods correlate with R2 = 0.70. Panel B. Podocyte density x glomerular volume gives the podocyte number per tuft. This value also correlates well with Glepp1 area (R2 = 0.63).
Jeffrey B. Hodgin (617121) +5 more
core +1 more source
Calcium sensing in podocytes [PDF]
Kidney International, 2011 Besides its primary function in maintaining systemic calcium homeostasis, the calcium-sensing receptor (CaSR) is expressed by many cell types, with different, sometimes opposite, regulatory functions. Novel work from Oh and collaborators shows that activation of CaSR in podocytes has prosurvival effects and protects the cell from puromycin ...
openaire +2 more sources
Role of the polarity protein Scribble for podocyte differentiation and maintenance.
PLoS ONE, 2012 The kidney filter represents a unique assembly of podocyte epithelial cells that tightly enwrap the glomerular capillaries with their complex foot process network. While deficiency of the polarity proteins Crumbs and aPKC result in impaired podocyte foot
Björn Hartleben +10 more
doaj +1 more source
Podocyte evaluation at 3 months after uninephrectomy.
, 2013 (A) Immunofluorescence study of glomerular synaptopodin and WT1 in each group. (B) Average glomerular podocyte number (evaluated using the number of WT1-positive staining nuclei) in each group. No differences were noted among the groups.
Ching Fang Wu (499087) +11 more
core +1 more source