Results 81 to 90 of about 31,106 (252)

Redox‐Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations

Journal of Applied Toxicology, EarlyView.
ABSTRACT Dexamethasone (DEX) is widely used in clinical practice, although it may also cause oxidative stress–related damage in different tissues, including the kidney and male reproductive system. This study investigated DEX‐induced renal and reproductive injury in rats and evaluated the modulatory effect of reduced glutathione on DEX‐associated redox
Caner Öztürk, Neşe Hayat Aksoy, Erkan Özkan, Ayşe Ikinci Keleş, Ahmet Karabulut   +4 more
wiley   +1 more source

Epigenetically Regulated NOX4/NRF2 Axis Mediates PM2.5‐Induced Ferroptosis and Inflammatory Response in Membranous Nephropathy

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aims to explore the involvement and mechanism of ferroptosis in particulate matter 2.5 (PM2.5)–induced membranous nephropathy (MN) progression. A cationic bovine serum albumin (cBSA)–induced mouse model of MN was established, followed by PM2.5 exposure.
Yanhong Gao, Yinfeng Guo, Shaoyan Xu, Min Zhang, Yanxia Rui, Shujun Pan, Changhua Zhou, Jianxiang Chen, Henglan Wu   +8 more
wiley   +1 more source

Notoginsenoside R1 Ameliorates Podocyte Adhesion Under Diabetic Condition Through α3β1 Integrin Upregulation in Vitro and in Vivo

Cellular Physiology and Biochemistry, 2014
Background: Decreased expression of α3β1 integrin may contribute to reduction in podocyte adhesion to glomerular basement membrane (GBM), which represents a novel early mechanism leading to diabetic kidney disease (DKD).
Dingkun Gui, Li Wei, Guihua Jian, Yongping Guo, Jiajun Yang, Niansong Wang   +5 more
doaj   +1 more source

The Association Between Stress‐Induced Hyperglycemia Ratio and Increased Urinary Albumin Excretion in Patients With Hypertension: A Population‐Based Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The stress hyperglycemia ratio (SHR), a novel marker reflecting relative hyperglycemia, has been increasingly recognized for its prognostic value in cardiovascular and metabolic diseases. However, its association with early renal damage in hypertensive patients remains underexplored.
Kai‐Jun Zhang, Yun Lan, Wen‐Feng Zeng, Rong‐Ting Zhang, Zhi‐Yi Ma, Xin Zou   +5 more
wiley   +1 more source

Podocyte Autophagy in Homeostasis and Disease [PDF]

, 2021
Autophagy is a protective mechanism that removes dysfunctional components and provides nutrition for cells. Podocytes are terminally differentiated specialized epithelial cells that wrap around the capillaries of the glomerular filtration barrier and ...
Jeremy S. Leventhal, Madhav C. Menon, Zhaohui Ni, Qisheng Lin, Khadija Banu   +4 more
core   +1 more source

Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice

Scientific Reports, 2022
Plasma ultrafiltration in the kidney occurs across glomerular capillaries, which are surrounded by epithelial cells called podocytes. Podocytes have a unique shape maintained by a complex cytoskeleton, which becomes disrupted in glomerular disease ...
William J. Mason, Daniyal J. Jafree, Gideon Pomeranz, Maria Kolatsi-Joannou, Antje K. Rottner, Sabrina Pacheco, Dale A. Moulding, Anja Wolf, Christian Kupatt, Claire Peppiatt-Wildman, Eugenia Papakrivopoulou, Paul R. Riley, David A. Long, Elisavet Vasilopoulou   +13 more
doaj   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Podocyte GTPases regulate kidney filter dynamics [PDF]

, 2012
Our concept of the kidney filtration barrier is changing from one of a static sieve into one of a highly dynamic structure regulated through the motility of podocyte foot processes.
Kistler, Andreas D., Altintas, Mehmet M., Reiser, Jochen   +2 more
core   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA/PI3K/AKT Pathway

Pediatric Discovery, EarlyView.
MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen, Chenxi Jia, Zhuocheng Shi, Bianan Zhu, Yihang Yu, Xing Liu, Feng Liu, Jianwei Chen, Tao Xu, Yuanyuan Zhang, Deying Zhang, Guanghui Wei   +11 more
wiley   +1 more source

Targeting podocyte-associated diseases☆ [PDF]

, 2010
Injury to the podocytes is the initiating cause of many renal diseases, leading to proteinuria with possible progression to end-stage renal disease. Podocytes are highly specialized cells, with an important role in maintaining the glomerular filtration ...
Jan Willem Leeuwis, Tri Q. Nguyen, Nguyen, Tri Q., Amélie Dendooven, Kok, Robbert J., Goldschmeding, Roe, Robbert J. Kok, Roel Goldschmeding, Leeuwis, Jan Willem, Dendooven, Amélie   +9 more
core   +1 more source