Results 81 to 90 of about 24,635 (230)
An update on the landscape of collagen bioactive fragments
The FEBS Journal, EarlyView.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Ferroptosis in Podocytes: An Emerging Focus in Kidney Diseases
BiologyFerroptosis is a mechanism of programmed cell death that is characterized by iron-dependent lipid peroxidation, and it is closely associated with organismal metabolism.
Jun Feng, Yiqiong Ma, Chunyun Zhang
doaj +1 more source
Podocyte Differentiation and Glomerulogenesis [PDF]
Journal of the American Society of Nephrology, 2003 This review will concentrate on the assembly of the glomerulus and the differentiation of the podocyte during that process. The differentiation of the vascular component of the glomerulus will not be emphasized, as it has been the subject of several recent reviews ([1][1]–[4][2]), except ...
openaire +2 more sources
Hepatology Research, EarlyView.Mineralocorticoid receptor antagonists are known to reduce proteinuria in chronic kidney disease, but their effectiveness in preventing bevacizumab‐related proteinuria has not been well established. In the present multi‐institutional retrospective study, we found that these agents significantly delay the onset of moderate or higher grade proteinuria ...
Tomoki Hori +17 more
wiley +1 more source
Journal of Diabetes Investigation, EarlyView.This TriNetX (US, 2016–2023) study compared clinical outcomes in patients with rheumatoid arthritis and type 2 diabetes treated with GLP‐1 receptor agonists vs DPP4 inhibitors. ABSTRACT Objectives To evaluate whether glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are associated with improved survival and renal outcomes in patients with ...
Yu‐Ting Yu +4 more
wiley +1 more source
Podocyte injury damages podocytes in chimeric organoids
Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenitor cells of two mouse lines: one expressing a receptor for a ...
Tomohiro Udagawa +3 more
openaire +1 more source
The Complement System in Post‐Transplant Kidney Injury
Organ Medicine, EarlyView.
Mengsi Hu
wiley +1 more source
Journal of Diabetes Investigation, EarlyView.High cumulative LDL‐C levels increase ESRD risk in type 2 diabetes, particularly among patients using insulin, those receiving multiple antidiabetic medications, and those with longer diabetes duration. Longer exposure to elevated LDL‐C further increases risk, underscoring the need for intensive LDL‐C control.
Da‐Yeon Lee +8 more
wiley +1 more source
Tmem30a protects against podocyte injury through suppression of pyroptosis
iScienceSummary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou +13 more
doaj +1 more source