Results 101 to 110 of about 33,221 (207)

FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice

Nature Communications
Podocyte injury is central to diabetic kidney disease (DKD) pathogenesis, however, the mechanisms underlying podocyte loss remain unclear. Emerging evidence underscores the involvement of fibroblast growth factors (FGFs) in renal pathophysiology. Here we
Jie Zhou, Shuxin Wang, Jiaxin Lou, Beibin Pan, Min Zhao, Qian Li, Jing Zhou, Yali Du, Shuodan Ding, Meiling Yu, Jingjing Zhou, Xinwei Chen, Lingwei Jin, Xinyi Wang, Yepeng Hu, Zhe Wang, Xiaokun Li, Chao Zheng, Jian Sun, Zhifeng Huang   +19 more
doaj   +1 more source

15th International Podocyte Conference, Hamburg, Germany, June 11-13, 2025. Abstracts: From Glomerular Biology to Glomerular Medicine

Glomerular Diseases
Over the past decades, the trajectory of podocyte biology and glomerular medicine has evolved into a globally connected, interdisciplinary field at the interface of cell biology, systems medicine, and clinical nephrology.
Laurel Damashek
doaj   +1 more source

CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy

Mediators of Inflammation, 2019
Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury.
Jing Zhao, Hong-liang Rui, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng   +5 more
doaj   +1 more source

Podocytes in health and glomerular disease

Frontiers in Cell and Developmental Biology
Podocytes are highly specialized, terminally differentiated cells in the glomerulus of the kidney and these cells play a central role in blood filtration.
Joanna Cunanan, Joanna Cunanan, Joanna Cunanan, Daniel Zhang, Daniel Zhang, Daniel Zhang, Anna Julie Peired, Moumita Barua, Moumita Barua, Moumita Barua   +9 more
doaj   +1 more source

Effects of BSF on Podocyte Apoptosis via Regulating the ROS-Mediated PI3K/AKT Pathway in DN

Journal of Diabetes Research, 2019
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The ROS-mediated PI3K/AKT pathway plays a key role in podocyte apoptosis and DN progression. Our previous study demonstrated that Baoshenfang (BSF) can decrease proteinuria
Fang-qiang Cui, Yue-Fen Wang, Yan-bin Gao, Yuan Meng, Zhen Cai, Cun Shen, Zhi-qiang Liu, Xin-can Jiang, Wen-jing Zhao   +8 more
doaj   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica
ABSTRACTAimPodocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective ...
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
openaire   +2 more sources

Morin Alleviates Fructose-Driven Disturbance of Podocyte Mitochondrial Energy Metabolism by Inhibiting Adenosine 5′-Monophosphate Deaminase Activity to Improve Glomerular Injury

Pharmaceuticals
Background/Objectives: High fructose consumption is a significant risk factor for glomerular podocyte injury. This study aimed to identify the underlying mechanism of fructose-induced podocyte injury and explore the protective effect of the natural ...
Yingzhi Yang, Ziyan Wan, Luyi Huang, Ziang Zhou, Wanru Wang, Yu Xing, Shijie Li, Yufan Du, Jiufang Huang, Yanqing Wu, Mengyu Fan, Jiahuang Li, Lingdong Kong, Dongmei Zhang   +13 more
doaj   +1 more source

Podocyte dysfunction in atypical haemolytic uraemic syndrome

, 2015
Genetic or autoimmune defects that lead to dysregulation of the alternative pathway of complement have been associated with the development of atypical haemolytic uraemic syndrome (aHUS), which is characterized by thrombocytopenia, haemolytic anaemia and
C. Mele, Giuseppe Remuzzi, G. Remuzzi, Caterina Mele, Marina Noris, M. Noris   +5 more
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Insulin signaling:implications for podocyte biology in diabetic kidney disease

, 2015
PURPOSE OF REVIEW: Several key elements of the insulin signaling cascade contribute to podocyte function and survival. While it was initially thought that the consequences of altered insulin signaling to podocyte function was strictly related to altered ...
Coward, Richard, Fornoni, Alessia
core   +1 more source

New Ways of Thinking about Proteinuria and Progression of Renal Damage [PDF]

, 2010
Zhou, Y. S., Turner, Neil
core   +1 more source