Results 121 to 130 of about 24,635 (230)

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Look Who Is Talking: Extracellular Vesicles as Mediators of Intercellular and Interorgan Communication

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Extracellular vesicles (EVs) mediate intercellular and interorgan communication during both physiological and pathological conditions. EVs include exosomes, ectosomes, and apoptotic bodies and contain bioactive molecules. EVs are delivered to proximal cells or can travel in bodily fluids and reach distant organs, where they trigger a response from the ...
Michela Saviana, Giulia Romano, Daniel del Valle‐Morales, Mario Acunzo, Patrick Nana‐Sinkam   +4 more
wiley   +1 more source

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

Characterization of NLRP3 Inflammasome‐Associated Hub Genes in the Progression of Diabetic Nephropathy

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
Expression of molecules related to the activation of NLRP3 inflammasomes and NIAHGs. (A) Immunoblot analysis of NLRP3, pro‐caspase‐1, caspase‐1 p20, and NIAHGs proteins in renal tissues from NC, eDN, and aDN patients. (B–E) Relative IL‐1β and IL‐18 levels across groups determined by RT‐qPCR (B, C) and ELISA (D, E).
Sheng Zhao, Yuejiao Li, Wenchuan Li, Lan Dong, Rong Lian, Qingqing Luo, Xingji Lian, Jianbo Li, Feng He   +8 more
wiley   +1 more source

Podometrics as a translational platform for kidney health and disease: Oshima award address 2025. [PDF]

Clin Exp Nephrol
Haruhara K.
europepmc   +1 more source

Magnetic‐Assisted Aptamer Selection and Isolation of Migrasomes for Application in Lung Adenocarcinoma Proteomic Analysis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Mag‐SELEX identified the first aptamer targeting migrasome, offering a potential ligand for their identification and detection in clinical samples. The magnetic aptamer probe, characterised by high specificity and rapid recovery, provides a simple, rapid, and economical method for elucidating migrasome mechanisms in disease and facilitating ...
Yixin Xu, Lin Jiao, Qiangying Yi, Yuzuo Chen, Bei Cai, Junlong Zhang, Zhuochun Huang, Yao Luo, Yanjun Si, Yao Wu, Binwu Ying, Jie Chen, Juan Zhou   +12 more
wiley   +1 more source

Immune podocyte injury in autoimmune glomerular diseases. [PDF]

Front Immunol
Zhu H, Sun J, Yan Y, Liu P, Huang Y.
europepmc   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Dynamics and Predictive Values of Urinary Podocyte Biomarkers Following SGLT2 Inhibition in CKD. [PDF]

Life (Basel)
Urs A, Moldovan D, Rusu CC, Bondor CI, Potra AR, Tirinescu D, Țicală M, Maslyennikov Y, Bărar AA, Dînșoreanu I, Kacso IM.   +10 more
europepmc   +1 more source

The IQGAP1‐Claudin4‐JNK Signaling Axis as a Differential Biomarker in Renal Cell Carcinoma

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Renal cell carcinoma (RCC) is a highly heterogeneous malignant neoplasm with multiple morphological and molecular subtypes; however, the basis of this heterogeneity remains incompletely defined, hindering effective diagnosis and treatment. The signaling scaffold IQGAP1 and claudins are tight junction protein partners involved in epithelial ...
Nahshon Puente, Xiuzhen Fan, Nagalakshmi Nadiminty, Obi Ekwenna, Firas G. Petros, Puneet Sindhwani, Amira Gohara, Evgeny Yakirevich, Mahasin A. Osman   +8 more
wiley   +1 more source