Results 121 to 130 of about 31,106 (252)

Preventive Effect of Mineralocorticoid Receptor Antagonists Against Proteinuria Induced by Atezolizumab Plus Bevacizumab Therapy in Hepatocellular Carcinoma: A Multicenter Retrospective Study

Hepatology Research, EarlyView.
Mineralocorticoid receptor antagonists are known to reduce proteinuria in chronic kidney disease, but their effectiveness in preventing bevacizumab‐related proteinuria has not been well established. In the present multi‐institutional retrospective study, we found that these agents significantly delay the onset of moderate or higher grade proteinuria ...
Tomoki Hori, Kazuhiro Yamamoto, Hiroshi Aoi, Yusuke Koizumi, Makoto Kuromatsu, Aiko Fukui, Hiroyo Okamoto, Atsushi Hirata, Kentaro Shinmori, Yuki Imanaka, Miyu Namba, Keisuke Nakanishi, Syunsuke Kitamura, Hideo Tsushima, Ikuko Yano, Kei Moriya, Masaru Matsui, Shigeki Ikushima   +17 more
wiley   +1 more source

Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses

Cell Reports
Summary: Signal-regulatory protein alpha (SIRPα) has recently been found to be highly expressed in podocytes and is essential for maintaining podocyte function. However, its immunoregulatory function in podocytes remains elusive.
Bin Qian, Rui Lu, Shuya Mao, Yang Chen, Miao Yang, Wenxuan Zhang, Mingchao Zhang, Dihan Zhu, Zhihong Liu, Ke Zen, Limin Li   +10 more
doaj   +1 more source

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu, Yu Fang, Meirong Xu, Zuopeng Lu, Yu Cao, Yana Gao   +5 more
wiley   +1 more source

Influence of Podocyte Injury on the Development of Class IV Lupus Nephritis [PDF]

Cyntia Camilo Franco Borges Zago,1 Bruna de Freitas Oliveira,1 Giovanna Uehara,1 Ana Laura Carvalho da Silva,1 Laura Penna Rocha,1 Fabiano Bichuette Custódio,2 Liliane Silvano Araújo,1 Crislaine Aparecida da Silva,1 Marlene Antônia Reis,1 Juliana Reis ...
Zago CCFB, Uehara G, Reis MA, Custódio FB, Oliveira BDF, Rocha LP, Araújo LS, da Silva CA, Machado JR, da Silva ALC   +9 more
core   +1 more source

Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]

, 2018
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Tahoun, Mona M., Robert D. Sampson, Mona M. Tahoun, Alex K. Virasami, Miller-Hodges, Eve V., Asfahani, Rowan I., Hohenstein, Peter, Peter J. Scambler, Moulding, Dale, Sebire, Neil J., Aoife M. Waters, Neil J. Sebire, Waters, Aoife M., Rowan I. Asfahani, Dale Moulding, Virasami, Alex K., Jack Bellerby, Bellerby, Jack, Eve V. Miller-Hodges, Sampson, Robert D., Scambler, Peter J., Peter Hohenstein   +21 more
core   +1 more source

Podocytes [PDF]

The American Journal of Pathology, 2020
Marica Giliberti, Adele Mitrotti, Loreto Gesualdo   +2 more
openaire   +1 more source

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao, Xiaohui Zhang, Peng Lu, Qiang Wang   +3 more
wiley   +1 more source

WT-1 (podocyte) staining from STNx rats. [PDF]

, 2015
As illustrated by representative photomicrographs, in comparison with sham rats (A), STNx rats (B) were associated with a significant increase in podocyte loss.
Elizabeth K. M. Johnstone (711520), Kevin D. G. Pfleger (176476), James H. Williams (489711), Mohammed Akli Ayoub (176430), Robyn S. Kelly (711519), Darren J. Kelly (252497), Heng B. See (587137), Elizabeth A. McCall (711521), Yuan Zhang (41832)   +8 more
core   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Ferroptosis in Podocytes: An Emerging Focus in Kidney Diseases

Biology
Ferroptosis is a mechanism of programmed cell death that is characterized by iron-dependent lipid peroxidation, and it is closely associated with organismal metabolism.
Jun Feng, Yiqiong Ma, Chunyun Zhang
doaj   +1 more source