Results 1 to 10 of about 37,285 (158)

Targeting DPP9 attenuates podocyte injury by regulating NRF2 antioxidant signaling. [PDF]

Front Pharmacol
Cui C, Wei S, Zhang J, Xu J, Naimova S, Li Y, Wang H, Wang Y, Si R, Wei L, Lei F, Yu X, Liu P, Fu R.   +13 more
europepmc   +3 more sources

The insulin/IGF axis is critically important for controlling gene transcription in the podocyte. [PDF]

Elife
Hurcombe JA, Dayalan L, Barrington F, Burdet F, Ni L, Coward JT, Ibberson M, Brinkkoetter PT, Holzenberger M, Jeffries AR, Oltean S, Welsh GI, Coward RJM.   +12 more
europepmc   +2 more sources

Differential regulation of basal and interferon-induced <i>APOL1</i> gene expression in podocytes. [PDF]

Am J Physiol Renal Physiol
Huang C, Wu Z, Bartolomeo KR, O'Toole JF, Sedor JR, Bruggeman LA.   +5 more
europepmc   +2 more sources

MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene

Frontiers in Medicine, 2021
Podocytes are an integral part of the glomerular filtration barrier. Many genes are already known to be essential for podocyte survival, structure and function, but there are more podocyte essential genes to be identified. By single-cell RNA-seq of mouse
Hui Song, Lulu Zhuang, Xiaodong Xu, Jingsong Shi, Weixin Hu, Zhihong Liu, Shaolin Shi   +6 more
doaj   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency. [PDF]

Adv Sci (Weinh)
Yang Q, Jiang H, Xiong C, Zhou X, Tan Q, Xiao H, Qiu L, Gan C, Chen Y, Yang H, Jiang W, Li Q.   +11 more
europepmc   +2 more sources

Podocyte injury damages podocytes in chimeric organoids. [PDF]

PLoS One
Udagawa T, Araoka T, Osafune K, Matsusaka T.   +3 more
europepmc   +3 more sources

Complement expression profiles in human glomerular mesangial cells, endothelial cells, podocytes and proximal tubular epithelial cells. [PDF]

Front Immunol
Gao Y, Li Q, Wang Y, Deng Z.
europepmc   +2 more sources

The directed differentiation of human iPS cells into kidney podocytes. [PDF]

PLoS ONE, 2012
The loss of glomerular podocytes is a key event in the progression of chronic kidney disease resulting in proteinuria and declining function. Podocytes are slow cycling cells that are considered terminally differentiated. Here we provide the first report
Bi Song, Alexandra M Smink, Christina V Jones, Judy M Callaghan, Stephen D Firth, Claude A Bernard, Andrew L Laslett, Peter G Kerr, Sharon D Ricardo   +8 more
doaj   +1 more source

Regulation of TRPML1 channel activity and inflammatory exosome release by endogenously produced reactive oxygen species in mouse podocytes

Redox Biology, 2021
The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome in podocytes has been implicated in the initiation of glomerular inflammation during hyperhomocysteinemia (hHcy).
Guangbi Li, Dandan Huang, Ningjun Li, Joseph K. Ritter, Pin-Lan Li   +4 more
doaj   +1 more source

Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.

PLoS ONE, 2023
Podocytes are key to preventing the filtration of serum proteins into the urine. Recent evidence also suggests that in immune mediated kidney diseases, podocytes are the targets of immune complexes (ICs).
George Haddad, James Dylewski, River Evans, Linda Lewis, Judith Blaine   +4 more
doaj   +1 more source