Results 41 to 50 of about 44,214 (194)

Transcriptional Regulation in Podocytes [PDF]

, 2020
Prolonged and progressive podocyte injury leads to extensive proteinuria, scarred glomeruli and a decline in renal function. When left untreated, it develops chronic kidney disease (CKD) which often has poor prognosis.
Rahmatollahi, Mahdieh
core   +1 more source

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

Cell Reports, 2019
Summary: The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of ...
Paul T. Brinkkoetter, Tillmann Bork, Sarah Salou, Wei Liang, Athanasia Mizi, Cem Özel, Sybille Koehler, H. Henning Hagmann, Christina Ising, Alexander Kuczkowski, Svenia Schnyder, Ahmed Abed, Bernhard Schermer, Thomas Benzing, Oliver Kretz, Victor G. Puelles, Simon Lagies, Manuel Schlimpert, Bernd Kammerer, Christoph Handschin, Christoph Schell, Tobias B. Huber   +21 more
doaj   +1 more source

Flying podocytes [PDF]

, 2009
Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al.
Simons, Matias, Huber, Tobias B.
core   +1 more source

Quantifying Podocytes and Parietal Epithelial Cells in Human Urine Using Liquid-based Cytology and WT1 Immunoenzyme Staining

Bio-Protocol, 2018
In glomerular disease, podocytes and parietal epithelial cells (PECs) are shed in the urine. Therefore, urinary podocytes and PECs are noninvasive biomarkers of glomerular disease.
Hiroyuki Ohsaki, Toru Matsunaga, Taishi Fujita, Yasunori Tokuhara, Shingo Kamoshida, Tadashi Sofue   +5 more
doaj   +1 more source

Free fatty acids cause podocytes dysfunction and inflammation

Journal of Biological Research, 2023
The mechanisms underlying obesity-related kidney disease are not well understood. Growing evidence suggests that free fatty acids (FFAs), a cause of oxidative stress, play an important role in obesity and its related complications.
Anna Laura Colia, Maria D'Apolito, Alessandra Ranaldi, Maria Francesca D'Ambrosio, Ida Giardino, Angela Bruna Maffione   +5 more
doaj   +1 more source

in podocytes

, 2008
The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads.
Morrison, Avril A., Saleem, Moin A., Moin A. Saleem, Avril A. Morrison, Michael R. Ladomery, Viney, Rebecca L., Rebecca L. Viney, Ladomery, Michael   +7 more
core   +1 more source

Unravelling the Role of PAX2 Mutation in Human Focal Segmental Glomerulosclerosis

Biomedicines, 2021
No effective treatments are available for familial steroid-resistant Focal Segmental Glomerulosclerosis (FSGS), characterized by proteinuria due to ultrastructural abnormalities in glomerular podocytes. Here, we studied a private PAX2 mutation identified
Lorena Longaretti, Piera Trionfini, Valerio Brizi, Christodoulos Xinaris, Caterina Mele, Matteo Breno, Elena Romano, Roberta Giampietro, Giuseppe Remuzzi, Ariela Benigni, Susanna Tomasoni   +10 more
doaj   +1 more source

Inhibition of SGLT2 protects podocytes in diabetic kidney disease by rebalancing mitochondria-associated endoplasmic reticulum membranes

Cell Communication and Signaling
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors have changed the therapeutic landscape for diabetic kidney disease (DKD) patients, but their underlying mechanisms are complicated and not fully understood.
Xuehong Li, Qiong Li, Xinying Jiang, Shicong Song, Wei Zou, Qinglan Yang, Sirui Liu, Shuangqin Chen, Cheng Wang   +8 more
doaj   +1 more source

Podocytes of PodoPalld129-/- mice show morphological abnormalities.

, 2021
(A) In Richardson’s stained semithin sections of PodoPalld129-/- mice we have found podocytes with enlarged subpodocyte space compared with controls as illustrated in the higher magnifications. Scale bar represents 10 μm.
Nadine Artelt (5908337), Stefan Simm (277838), Rabea Schlüter (436836), Karlhans Endlich (112716), Jens van den Brandt (70393), Alina M. Ritter (5908343), Felix Kliewe (11812931), Nicole Endlich (170572), Linda Leitermann (11812928)   +8 more
core   +1 more source

Réponses métaboliques distinctes des podocytes à l’exposition au palmitate et à l’oléate [PDF]

A key feature of obesity-related chronic kidney disease (CKD) is the alteration of the glomerulus, known as obesity-related glomerulopathy (ORG). In this condition, podocytes, highly specialized glomerular epithelial cells, are primary targets.
Arnould, Thierry, Esteve, Emmanuel, Delneste, Flore, Hecq, Aurore, Thirion, Marine, Nortier, Antoine, Decleves, Anne-Emilie   +6 more
core   +1 more source