Results 21 to 30 of about 28,010 (204)
The podocyte and the proteoglycan [PDF]
American Journal of Physiology-Renal Physiology, 2016 proteoglycans (PGs) consist of a core protein and linear sugar side chains [glycosaminoglycans (GAGs)] attached to the core protein, e.g., agrin, perlecan, glypican, and syndecan. GAGs comprise repeating duplex sugar units made of an aminosugar (e.g., N -acetylglucosamine or N -acetylgalactosamine)
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Podocyte Lipotoxicity in CKD [PDF]
Kidney360, 2021 CKD represents the ninth most common cause of death in the United States but, despite this large health burden, treatment options for affected patients remain limited. To remedy this, several relevant pathways have been identified that may lead to novel therapeutic options.
Jin-Ju, Kim +2 more
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JCI Insight, 2021 The transcription factor Twist1 regulates several processes that could impact kidney disease progression, including epithelial cell differentiation and inflammatory cytokine induction.
Jiafa Ren +9 more
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Scientific Reports, 2023 Mycophenolate Mofetil (MMF) has an established role as a therapeutic agent in childhood nephrotic syndrome. While other immunosuppressants have been shown to positively affect podocytes, direct effects of MMF on podocytes remain largely unknown.
Seif El Din Abo Zed +12 more
doaj +1 more source
Autoimmunity, 2023 Aggravated endoplasmic reticulum stress (ERS) and apoptosis in podocytes play an important role in lupus nephritis (LN) progression, but its mechanism is still unclear.
Xiaoyan Li +5 more
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Podocyte Mitosis - A Catastrophe [PDF]
Current Molecular Medicine, 2012 Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm.
LASAGNI, LAURA +4 more
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Kidney360, 2023 As the population in many industrial countries is aging, the risk, incidence, and prevalence of CKD increases. In the kidney, advancing age results in a progressive decrease in nephron number and an increase in glomerulosclerosis. In this review, we focus on the effect of aging on glomerular podocytes, the post-mitotic epithelial cells critical for the
Stuart J. Shankland +4 more
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Journal of Clinical Investigation, 2011 The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental ...
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Crosstalk Between SMPDL3b and NADPH Oxidases Mediates Radiation-Induced Damage of Renal Podocytes
Frontiers in Medicine, 2021 Patients undergoing radiotherapy (RT) for various tumors localized in the abdomen or pelvis often suffer from radiation nephrotoxicity as collateral damage. Renal podocytes are vulnerable targets for ionizing radiation and contribute to radiation-induced
Patrick Azzam +9 more
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The Role of Palladin in Podocytes [PDF]
Journal of the American Society of Nephrology, 2018 Background Podocyte loss and effacement of interdigitating podocyte foot processes are the major cause of a leaky filtration barrier and ESRD. Because the complex three-dimensional morphology of podocytes depends on the actin cytoskeleton, we studied the role in podocytes of the actin bundling protein palladin, which is ...
Artelt, Nadine +13 more
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