Results 11 to 20 of about 44,214 (194)

Establishment of protein delivery systems targeting podocytes. [PDF]

PLoS ONE, 2010
Podocytes are uniquely structured cells that are critical to the kidney filtration barrier. Their anatomic location on the outer side of the glomerular capillaries expose podocytes to large quantities of both plasma and urinary components and thus are ...
Wen Chih Chiang, Tessa M Geel, Mehmet M Altintas, Sanja Sever, Marcel H J Ruiters, Jochen Reiser   +5 more
doaj   +4 more sources

Podocytes [version 1; referees: 2 approved]

F1000Research, 2016
Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule. When it comes to glomerular filtration, podocytes play an active role in preventing plasma proteins from ...
Jochen Reiser, Mehmet M. Altintas
doaj   +2 more sources

C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes

Scientific Reports, 2022
Podoplanin (PDPN) is intensely expressed on the podocyte membrane in an evolutionally conserved manner. CLEC-2, the endogenous ligand of PDPN, is highly expressed in platelets and also exists in a soluble form in plasma.
Keiko Tanaka, Masafumi Tanaka, Nobuo Watanabe, Masatoshi Ito, Ira Pastan, Masahiro Koizumi, Taiji Matsusaka   +6 more
doaj   +1 more source

Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease

Stem Cell Research & Therapy, 2022
Background In diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture of podocytes is crucial for modeling of diabetic nephropathy and genetic podocytopathies and to ...
Julie Bejoy, Justin M. Farry, Jennifer L. Peek, Mariana C. Cabatu, Felisha M. Williams, Richard C. Welch, Eddie S. Qian, Lauren E. Woodard   +7 more
doaj   +1 more source

Gomerulus & Podocytes

, 2011
This is a painting representation of a Scanning Electron Microscope image (of about 5,000x) of the glomerulus, podocytes and glomarular filtrates of the kidneys created in Adobe Photoshop.
Gabriela Perazza (7916732)
core   +6 more sources

Hsa_circ_0037128 aggravates high glucose-induced podocytes injury in diabetic nephropathy through mediating miR-31-5p/KLF9

Autoimmunity, 2022
Background Circular RNA is a key regulator involved in the progression of many human diseases including diabetic nephropathy (DN). However, the role and mechanism of hsa_circ_0037128 in the occurrence and development of DN remains to be explored. Methods
Rong Fang, Xiangchang Cao, Yaping Zhu, Qiming Chen   +3 more
doaj   +1 more source

Triptolide ameliorates fine particulate matter-induced podocytes injury via regulating NF-κB signaling pathway

BMC Molecular and Cell Biology, 2020
Background PM2.5 is associated closely with an increased risk of membranous nephropathy (MN), however, whether PM2.5 could induce podocytes injury, the underlying pathology for MN, has not be thoroughly studied.
Qiang Wan, Zhongyong Liu, Ming Yang, Peng Deng, Nana Tang, Yanwei Liu   +5 more
doaj   +1 more source

Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System. [PDF]

PLoS ONE, 2015
Together with mesangial cells, glomerular endothelial cells and the basement membrane, podocytes constitute the glomerular filtration barrier (GFB) of the kidney. Podocytes play a pivotal role in the progression of various kidney-related diseases such as
Ganesh Ram R Visweswaran, Shima Gholizadeh, Marcel H J Ruiters, Grietje Molema, Robbert J Kok, Jan A A M Kamps   +5 more
doaj   +1 more source

ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease

Scientific Reports, 2023
Decreased ATP Binding Cassette Transporter A1 (ABCA1) expression and caspase-4-mediated noncanonical inflammasome contribution have been described in podocytes in diabetic kidney disease (DKD).
Marie Ito, Gloria Michelle Ducasa, Judith David Molina, Javier Varona Santos, Shamroop Kumar Mallela, Jin Ju Kim, Mengyuan Ge, Alla Mitrofanova, Alexis Sloan, Sandra Merscher, Imari Mimura, Alessia Fornoni   +11 more
doaj   +1 more source

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H

Frontiers in Immunology, 2020
Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig, Anne K. Mühlig, Lindsay S. Keir, Jana C. Abt, Hannah S. Heidelbach, Rachel Horton, Gavin I. Welsh, Catherine Meyer-Schwesinger, Christoph Licht, Richard J. Coward, Lars Fester, Lars Fester, Moin A. Saleem, Jun Oh, Jun Oh   +14 more
doaj   +1 more source