Results 31 to 40 of about 44,214 (194)

Fatty acids and their metabolism critically regulate podocyte survival [PDF]

, 2014
Diabetic nephropathy (DN) is the most common cause of end-stage renal disease in industrialized countries, and most affected patients have type 2 diabetes.
Kampe, Kapil Dev
core   +1 more source

Crosstalk Between SMPDL3b and NADPH Oxidases Mediates Radiation-Induced Damage of Renal Podocytes

Frontiers in Medicine, 2021
Patients undergoing radiotherapy (RT) for various tumors localized in the abdomen or pelvis often suffer from radiation nephrotoxicity as collateral damage. Renal podocytes are vulnerable targets for ionizing radiation and contribute to radiation-induced
Patrick Azzam, Marina Francis, Tarek Youssef, Manal Mroueh, Alaa Abou Daher, Assaad A. Eid, Alessia Fornoni, Brian Marples, Youssef H. Zeidan, Youssef H. Zeidan   +9 more
doaj   +1 more source

Epigenetic Alterations in Podocytes in Diabetic Nephropathy

Frontiers in Pharmacology, 2021
Recently, epigenetic alterations have been shown to be involved in the pathogenesis of diabetes and its complications. Kidney podocytes, which are glomerular epithelial cells, are important cells that form a slit membrane—a barrier for proteinuria ...
Erina Sugita, Kaori Hayashi, Akihito Hishikawa, Hiroshi Itoh   +3 more
doaj   +1 more source

Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria

Cell Death and Disease, 2021
Glomerular podocytes are integral members of the glomerular filtration barrier in the kidney and are crucial for glomerular permselectivity. These highly differentiated cells are vulnerable to an array of noxious stimuli that prevail in several ...
Rajkishor Nishad, Dhanunjay Mukhi, Ashish Kumar Singh, Manga Motrapu, Kumaraswami Chintala, Prasad Tammineni, Anil K. Pasupulati   +6 more
doaj   +1 more source

Preparation of Human Kidney Progenitor Cultures and Their Differentiation into Podocytes

Bio-Protocol, 2023
Kidney diseases are a global health concern. Modeling of kidney disease for translational research is often challenging because of species specificities or the postmitotic status of kidney epithelial cells that make primary cultures, for example ...
Maria Elena Melica, Maria Lucia Angelotti, Giulia Antonelli, Anna Peired, Carolina Conte, Letizia De Chiara, Benedetta Mazzinghi, Elena Lazzeri, Laura Lasagni, Paola Romagnani   +9 more
doaj   +1 more source

The expression and significance of neuronal iconic proteins in podocytes.

PLoS ONE, 2014
Growing evidence suggests that there are many common cell biological features shared by neurons and podocytes; however, the mechanism of podocyte foot process formation remains unclear. Comparing the mechanisms of process formation between two cell types
Yu Sun, Hongxia Zhang, Ruimin Hu, Jianyong Sun, Xing Mao, Zhonghua Zhao, Qi Chen, Zhigang Zhang   +7 more
doaj   +1 more source

CRIT is expressed on podocytes in normal human kidney and upregulated in membranous nephropathy [PDF]

, 2006
Complement C2 receptor inhibitor trispanning (CRIT) is a novel human complement regulatory cell surface receptor. It binds the human complement protein C2 and blocks the classical pathway of complement activation, thus protecting the cell against ...
Mihatsch, M J, Inal, J., J.M. Inal, Mihatsch M, J., S. Lange, M.J. Mihatsch, Schifferli, J., S. Moll, Lange, S, Schifferli, J A, Inal, J.M., Z. Dragic, Dragic, Z, Moll, S., Lange, S., Mihatsch, M.J., J.A. Schifferli, Dragic, Z., Moll, Solange, Inal, J M, Schifferli, J.A.   +20 more
core   +1 more source

A Liquid-Based Cytology System, without the Use of Cytocentrifugation, for Detection of Podocytes in Urine Samples of Patients with Diabetic Nephropathy

Journal of Diabetes Research, 2019
Objective. Podocytes have highly differentiated functions and are extremely difficult to grow; thus, damage of podocytes is associated with glomerular dysfunction.
Moritsugu Kimura, Masao Toyoda, Nobumichi Saito, Noriko Kaneyama, Han Miyatake, Eitaro Tanaka, Hirotaka Komaba, Masanori Hara, Masafumi Fukagawa   +8 more
doaj   +1 more source

ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases

Journal of Biomedical Science, 2010
Background The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of the Notch signaling complex ...
Weide Thomas, Hillmann Anja, Gauer Stefan, Altevogt Peter, Ludwig Andreas, Hauser Ingeborg A, Doberstein Kai, Abdel-Bakky Mohamed, Schramme Anja, Gutwein Paul, Jespersen Christine, Eberhardt Wolfgang, Pfeilschifter Josef   +12 more
doaj   +1 more source

Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome

eLife, 2023
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are anti-hyperglycemic agents that prevent glucose reabsorption in proximal tubular cells. SGLT2i improves renal outcomes in both diabetic and non-diabetic patients, indicating it may have beneficial ...
Mengyuan Ge, Judith Molina, Jin-Ju Kim, Shamroop K Mallela, Anis Ahmad, Javier Varona Santos, Hassan Al-Ali, Alla Mitrofanova, Kumar Sharma, Flavia Fontanesi, Sandra Merscher, Alessia Fornoni   +11 more
doaj   +1 more source