Results 51 to 60 of about 44,214 (194)

Angiotensin II modulates cellular functions of podocytes [PDF]

, 1998
Angiotensin II modulates cellular functions of podocytes. The aim of this study was to examine the effects of angiotensin II (Ang II) on membrane voltage (Vm) and cytosolic calcium activity ([Ca2+]i) of rat podocytes.
Greger, Rainer F, Mundel, Peter, Fischer, Karl-Georg, Nitschke, Roland, Greger, Rainer, Pavenstädt, Hermann, Schollmeyer, Peter, Bleich, Markus, Henger, Anna, Schollmeyer, Peter J., Gloy, Joachim   +10 more
core   +1 more source

The role of rapamycin in the PINK1/Parkin signaling pathway in mitophagy in podocytes

Open Life Sciences
This study aimed to clarify the role of rapamycin in the PINK1/Parkin signaling pathway in mitophagy in podocytes and the role of voltage-dependent anion channel 1 (VDAC1) in the PINK1/Parkin signaling pathway in mouse glomerular podocytes.
Yu Shengyou, Zhu Weixue, Yu Li
doaj   +1 more source

Activation of the Nrf2-ARE Pathway Ameliorates Hyperglycemia-Mediated Mitochondrial Dysfunction in Podocytes Partly Through Sirt1

Cellular Physiology and Biochemistry, 2018
Background/Aims: Previously we have shown that activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) attenuated hyperglycemia-induced damage in podocytes, but the molecular mechanism remains unknown ...
Qunzi Zhang, Qiongxia Deng, Jun Zhang, JianTing Ke, Ye Zhu, Ruo wei Wen, Zengchun Ye, Hui Peng, Zhong zhen Su, Cheng Wang, Tanqi Lou   +10 more
doaj   +1 more source

Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection

Journal of Nanobiotechnology
Background Podocytes are a crucial component of the glomerular filtration barrier, and changes in their 3D structure contribute to over 80% of chronic kidney disease (CKD) cases.
Tim Lange, Luzia Maron, Claudia Weber, Doreen Biedenweg, Rabea Schlüter, Nicole Endlich   +5 more
doaj   +1 more source

Adaptation métabolique des podocytes à l’exposition aux acides gras [PDF]

A key feature of obesity-related chronic kidney disease (CKD) is the alteration of the glomerulus, known as obesity-related glomerulopathy (ORG). In this condition, podocytes, highly specialized glomerular epithelial cells, are the main target.
Arnould, Thierry, Esteve, Emmanuel, Hecq, Aurore, Thirion, Marine, Nortier, Antoine, Decleves, Anne-Emilie   +5 more
core   +1 more source

Autophagy downregulation contributes to insulin resistance mediated injury in insulin receptor knockout podocytes in vitro [PDF]

PeerJ, 2016
It is unknown whether autophagy activity is altered in insulin resistant podocytes and whether autophagy could be a therapeutic target for diabetic nephropathy (DN).
Ying Xu, Qi Zhou, Wei Xin, Zhaoping Li, Liyong Chen, Qiang Wan   +5 more
doaj   +2 more sources

Insulin Increases Expression of TRPC6 Channels in Podocytes by a Calcineurin-Dependent Pathway

Cellular Physiology and Biochemistry, 2016
Background/Aims: Insulin signaling to podocytes is relevant for the function of the glomerulus. Now, we tested the hypothesis that insulin increases the surface expression of canonical transient receptor potential canonical type 6 (TRPC6) channels in ...
Shengqiang Xia, Ying Liu, Xinming Li, Florian Thilo, Martin Tepel   +4 more
doaj   +1 more source

Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma

Kidney Research and Clinical Practice, 2016
Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain–secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause light-chain proximal
Eun Jeong Lee, Su Yeon Lee, So Young Park, Yonjin Kim, Jae Shin Choi, Mi Jeoung Kim, Ji Hyeon Park, Jung Eun Lee, Ghee Young Kwon, Yoon-Goo Kim   +9 more
doaj   +1 more source

GABA ameliorates diabetic kidney disease-induced podocyte injury via JAML-FPR2 axis-mediated suppression of macrophage infiltration [PDF]

Yibo Zhuang, Chenlu Fu, Zheng Guo, Yan Xu, Jun Zhou, Huiping Ni, Aihua Zhang   +6 more
  +4 more sources

Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes

Journal of Diabetes Research, 2020
Tangshen Formula (TSF) is a Chinese Medicine formula that has been reported to alleviate proteinuria and protect renal function in humans and animals with diabetic kidney disease (DKD).
Qian Wang, Xuefei Tian, Wei’e Zhou, Yan Wang, Hailing Zhao, Jialin Li, Xuefeng Zhou, Haojun Zhang, Tingting Zhao, Ping Li   +9 more
doaj   +1 more source