Results 71 to 80 of about 44,214 (194)

Dach1 is essential for maintaining normal mature podocytes.

PLoS ONE
Dach1 is highly expressed in normal podocytes, but this expression rapidly disappears after podocyte injury. To investigate the role of Dach1 in podocytes in vivo, we analyzed global, podocyte-specific, and inducible Dach1 knockout mice.
Keiko Tanaka, Haruko Hayasaka, Taiji Matsusaka   +2 more
doaj   +1 more source

VEGF regulates TRPC6 channels in podocytes

, 2011
BACKGROUND: Both, increased plasma concentrations of vascular endothelial growth factor (VEGF) and increased expression of transient receptor potential canonical type 6 (TRPC6) channels in podocytes have been associated with proteinuric kidney diseases ...
R. Schuelein, Zhu, Z., Loddenkemper, Christoph, Gollasch, Maik, M. Tepel, A. Schmidt, Thilo, Florian, Zhu, Zhiming, Gollasch, M., Z. Yan, Yan, Zengcheng, Schmidt, Antje, M. Gollasch, Schmidt, A., Loddenkemper, C., Zakrzewicz, A., Tepel, Martin; id_orcid, Liu, Y., Thilo, F., Liu, Ying, Schuelein, Ralf, Zakrzewicz, Andreas, A. Zakrzewicz, Z. Zhu, Y. Liu, F. Thilo, C. Loddenkemper, Schuelein, R., Yan, Z., Tepel, M.   +29 more
core   +1 more source

Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

, 2018
Nianxiu Tian,1 Yanbin Gao,1 Xiaolei Wang,1 Xiaoming Wu,2 Dawei Zou,3 Zhiyao Zhu,3 ZheJi Han,1 Tao Wang,1 Yimin Shi1 1Department of Endocrinology, School of Traditional Chinese Medicine, Capital Medical University, Fengtai District, Beijing, China ...
Zhu Z, Wang T, Gao Y, Wang X, Tian N, Zou D, Han ZJ, Wu X, Shi Y   +8 more
core  

Assessment of podocyte detachment as a pivotal step in the development of focal segmental glomerulosclerosis

Journal of the Egyptian National Cancer Institute
Background Podocytopenia refers to a decrease in the number of podocytes. When podocytes are injured, they may detach leading to podocytopenia, which represents a critical step in the development of podocytopathy and subsequently deterioration of renal ...
Ikbal Ahmed Abdo Elkholy, Wagdi Elkashef, Fatma El-Husseini Mostafa, Amany Hassan   +3 more
doaj   +1 more source

Podocytes Are Nonhematopoietic Professional Antigen-Presenting Cells

, 2013
Podocytes are essential to the structure and function of the glomerular filtration barrier; however, they also exhibit increased expression of MHC class II molecules under inflammatory conditions, and they remove Ig and immune complexes from the ...
Daniel, Christoph, Steinkasserer, Alexander, Goldwich, Andreas, Burkard, Miriam, Ölke, Martha, Amann, Kerstin, Gessner, André, Hugo, Christian, Kurts, Christian   +8 more
core   +1 more source

Isolation of Podocyte Cell Fractions From Mouse Kidney Using Magnetic Activated Cell Sorting (MACS)

Bio-Protocol
Glomerular diseases characterized by injury to post-mitotic epithelial cells called podocytes are a leading cause of chronic kidney disease. Yet, isolating podocytes from the kidney for transcriptomic, proteomic, and metabolomic studies has been a major ...
Jeffrey Pippin, Carol Loretz, Diana Eng, Oliver Wessely, Stuart Shankland   +4 more
doaj   +1 more source

PKA signaling promoted mitochondria fusion in podocytes.

, 2014
A and B: Western blot of podocytes treated with pCPT-cAMP for the indicated time. Bar graph of data obtained from five independent experiments. C and D: Western blot results from podocytes treated with pCPT-cAMP for 30 and 60 minutes.
Zhaohui Ni (229588), Yucheng Yan (539035), John Cijiang He (322606), Xiaoying Li (147528), Peter Y. Chuang (322602), Kai Wei (311192), Hua Tao (450717), Kewei Xie (539034), Leyi Gu (539036)   +8 more
core   +1 more source

The Role of Palladin in Podocytes

, 2018
International audienceBackground Podocyte loss and effacement of interdigitating podocyte foot processes are the major cause of a leaky filtration barrier and ESRD.
Kerstin Amann, Henrik Rogge, Endlich, Nicole, Karlhans Endlich, Chadjichristos, Christos, Kavvadas, Panagiotis, Rogge, Henrik, Otey, Carol, Endlich, Karlhans, Ludwig, Tim, Marie-Louise Bang, Nadine Artelt, Jens van den Brandt, Chatziantoniou, Christos, Blumenthal, Antje, Tim A. Ludwig, Antje Blumenthal, Christos E. Chadjichristos, Siegerist, Florian, Bang, Marie-Louise, Carol A. Otey, Artelt, Nadine, Nicole Endlich, Christos Chatziantoniou, Amann, Kerstin, Panagiotis Kavvadas, Florian Siegerist, van den Brandt, Jens   +27 more
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Indoxyl sulfate injures human podocytes.

, 2014
Immunofluorescence images of autopsied human kidneys shows juxtaposition of AhR in podocyte nuclei surrounded by cytoplasm expressing synaptopodin (a). AhR (red), synaptopodin (green), and normal rabbit IgG control.
Masaaki Ueno (632625), Yasuhiro Kon (58978), Teppei Nakamura (466554), Weiping Chen (237540), Avi Z. Rosenberg (632626), Osamu Ichii (339354), Saori Otsuka-Kanazawa (582171), Jeffrey B. Kopp (217081)   +7 more
core   +1 more source

Formation of tight junctions between neighboring podocytes is an early ultrastructural feature in experimental crescentic glomerulonephritis

, 2016
Lena Succar,1 Ross A Boadle,2 David C Harris,1,3 Gopala K Rangan1,3 1Centre for Transplant and Renal Research, The Westmead Institute for Medical Research, The University of Sydney, 2Electron Microscopy Laboratory, Institute of Clinical Pathology and ...
Harris DC, Succar L, Rangan GK, Boadle RA   +3 more
core