Results 71 to 80 of about 28,010 (204)

Podocyte Differentiation and Glomerulogenesis [PDF]

Journal of the American Society of Nephrology, 2003
This review will concentrate on the assembly of the glomerulus and the differentiation of the podocyte during that process. The differentiation of the vascular component of the glomerulus will not be emphasized, as it has been the subject of several recent reviews ([1][1]–[4][2]), except ...
openaire   +2 more sources

Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan, Rongfang Feng, Mai Luo, Yaqi Wang, Min Gao, Qin Chen, Yufei Zhang, Yale Liu, Yumin Xia   +8 more
wiley   +1 more source

Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells

Frontiers in Immunology, 2018
Calcium calmodulin kinase IV (CaMK4) regulates multiple processes that significantly contribute to the lupus-related pathology by controlling the production of IL-2 and IL-17 by T cells, the proliferation of mesangial cells, and the function and ...
Andrew P. Ferretti, Rhea Bhargava, Shani Dahan, Maria G. Tsokos, George C. Tsokos   +4 more
doaj   +1 more source

Glomerular endothelial derived vesicles mediate podocyte dysfunction: A potential role for miRNA.

PLoS ONE, 2020
MicroRNAs (miRNA) are shown to be involved in the progression of several types of kidney diseases. Podocytes maintain the integrity of the glomerular basement membrane.
N Hill, D L Michell, M Ramirez-Solano, Q Sheng, C Pusey, K C Vickers, K J Woollard   +6 more
doaj   +1 more source

Bridging Kidney Organoid Innovation and Regenerative Medicine: Current Advances and Future Directions

Cell Proliferation, EarlyView.
This review outlines kidney organoid differentiation strategies, key developmental mechanisms, and engineering and multi‐omics approaches driving their progress toward regenerative medicine. ABSTRACT Chronic kidney disease (CKD) has emerged as a critical public health challenge worldwide, and organ donor shortages underscore the urgent need for ...
Bohong Guo, Jingyuan Zhang, Xuening Fang, Yangyang Liu, Yueyang Deng, Yuxin Xue, Zhengxi Wang, Xiaotao Dong, Mengqi Jia, Xiaodong Li   +9 more
wiley   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica
ABSTRACTAimPodocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective ...
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
openaire   +2 more sources

Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease

International Journal of Nephrology, 2017
Background. Despite enzyme replacement therapy, Fabry nephropathy still progresses. Podocyturia is an irreversible event that antedates proteinuria and leads to chronic renal failure.
Hernán Trimarchi, Romina Canzonieri, Amalia Schiel, Juan Politei, Cristian Costales-Collaguazo, Aníbal Stern, Matías Paulero, Tatiana Rengel, Lara Valiño-Rivas, Mariano Forrester, Fernando Lombi, Vanesa Pomeranz, Romina Iriarte, Alexis Muryan, Alberto Ortiz, María Dolores Sanchez-Niño, Elsa Zotta   +16 more
doaj   +1 more source

MicroRNA-770-5p contributes to podocyte injury via targeting E2F3 in diabetic nephropathy [PDF]

Brazilian Journal of Medical and Biological Research
Diabetic nephropathy (DN) has been identified as the major cause of end-stage renal disease (ESRD) in most developed countries. MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F ...
Juanjuan Guo, Jie Han, Jieying Liu, Shaoli Wang   +3 more
doaj   +2 more sources

The insulin‐like growth factor system and the progression of renal complications of type 2 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Adrian Heald, Yasitha lllangasekera, Andreas Matheou, Ram Prakash Narayanan, Stephen White, Hellena Habte‐Asres, Abigail Lay, Liliana Shalamanova, William Ollier, Graham A. Hitman, Ritwika Mallik, Philip A. Kalra, Martin Whyte, J. Martin Gibson   +13 more
wiley   +1 more source